Article
Food Science & Technology
Julieta N. Naso, Fernando A. Bellesi, Victor M. Pizones Ruiz-Henestrosa, Ana M. R. Pilosof
Summary: This study demonstrates that the solubilization capacity of bile salt micelles for fatty acids is influenced by emulsion components, as well as the concentration of the emulsifier. The increased concentration of the emulsifier affects the kinetics of lipolysis in oil-in-water emulsions, potentially impacting the bioavailability of fatty acids.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Samuel A. J. Trammell, Luke F. Gamon, Kamil Gotfryd, Katja Thoroe Michler, Bandar D. Alrehaili, Iben Rix, Filip K. Knop, Pontus Gourdon, Yoon-Kwang Lee, Michael J. Davies, Matthew P. Gillum, Trisha J. Grevengoed
Summary: The study demonstrates that NATs, bioactive lipids involved in glucose homeostasis and lipid metabolism, are synthesized in human and mouse livers. The hepatic NAT synthase activity depends on BAAT, which expands the known substrates of BAAT beyond classic bile acids. This finding enhances our understanding of lipid metabolism and the role of bioactive lipids.
JOURNAL OF LIPID RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Yulia Shulpekova, Elena Shirokova, Maria Zharkova, Pyotr Tkachenko, Igor Tikhonov, Alexander Stepanov, Alexandra Sinitsyna, Alexander Izotov, Tatyana Butkova, Nadezhda Shulpekova, Vladimir Nechaev, Igor Damulin, Alexey Okhlobystin, Vladimir Ivashkin
Summary: Bile acids play crucial physiological roles in the human body. They are essential for the absorption and excretion of nutrients and also act as sensors for intestinal contents, regulating their effects through processes such as intestinal absorption. Bile acids have significant impacts on liver function, cholesterol synthesis, and detoxification of xenobiotics. Their synthesis and regulation in different parts of the digestive tract are vital, as is their interaction with the intestinal microbiota.
Review
Gastroenterology & Hepatology
Hwi Young Kim
Summary: The clinical spectrum of NAFLD ranges from simple steatosis to NASH, with liver biopsy being the standard for diagnosis. Metabolomics has emerged as a promising diagnostic method to uncover metabolic alterations relevant to NASH progression, with recent research efforts focusing on lipidomics, amino acids, and bile acid metabolomics to discover potential biomarkers.
CLINICAL AND MOLECULAR HEPATOLOGY
(2021)
Article
Medicine, General & Internal
Jung Wan Choe, Jae Min Lee, Jong Jin Hyun, Hong Sik Lee
Summary: The study identifies microbial dysbiosis and changes in bile components as important factors leading to recurrent bile duct stone formation, especially infection with bacteria exhibiting beta-glucuronidase activity. Compared to the non-recurrence group, the recurrence group showed lower microbial richness and evenness, with distinct overall microbial communities.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Chemistry, Physical
Md. Nazrul Islam, Malik Abdul Rub, Md. Rafikul Islam, Md. Abdul Goni, Shahed Rana, Dileep Kumar, Abdullah M. Asiri, Yousef G. Alghamdi, Md. Anamul Hoque, Shariff E. Kabir
Summary: This study investigated the potential interactions between the antibiotic ceftriaxone sodium (CTS) and the surfactant triton X-100 (TX-100) in the presence and absence of various sodium based electrolytes and hydrotropic salts. The results showed that the hydrophilic interaction was significant when sodium salicylate (NaSal) was used, but not significant when sodium benzoate (NaBenz) was used. Thermodynamic variables were calculated to evaluate the nature of the interactions, and the findings may have important implications for pharmaceutical formulations and understanding drug-surfactant interactions.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Review
Polymer Science
Ilya Nifant'ev, Pavel Ivchenko
Summary: Biodiesel faces limitations due to poor cold-flow properties, but additives show promise in enhancing its performance.
Article
Medicine, Research & Experimental
Devika Nair, Mehrdad Zarei, Prakash Halami, Ramaprasad Talahalli
Summary: This study investigated the effects of Lactobacillus fermentum MCC2760 on intestinal bile acid uptake, hepatic bile acid synthesis, and enterohepatic bile acid transporters in hyperlipidemic rats. The results showed that MCC2760 supplementation could alleviate the abnormal changes in bile acid uptake, synthesis, and transport induced by a high-fat diet in rats.
Article
Pharmacology & Pharmacy
Liang Huang, Wei Wei, Xiaomei Huang, Xuejing Li, Haisha Liu, Lanlan Gui, Jinping Jiang, Linfei Wan, Xiangxiang Zhou, Jingsong Ding, Xuehua Jiang, Bikui Zhang, Ke Lan
Summary: This study investigated the effects of high-fat diets on the pharmacokinetics of ursodeoxycholic acid (UDCA) and the circulating bile salt levels. The results showed that high-fat diets delayed the absorption of UDCA but enhanced its metabolite. However, the high-fat diets also led to an increase in circulating hydrophobic bile salts, which may limit the effectiveness of UDCA.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Silke Matysik, Sabrina Krautbauer, Gerhard Liebisch, Hans-Frieder Schott, Louise Kjolbaek, Arne Astrup, Francois Blachier, Martin Beaumont, Max Nieuwdorp, Annick Hartstra, Simone Rampelli, Uberto Pagotto, Patricia Iozzo
Summary: This study quantified the concentrations of faecal sterol species, bile acids, and short-chain fatty acids in 165 study participants. Participants were classified as low or high converters based on their coprostanol/cholesterol ratio, with low converters excreting more straight-chain fatty acids and bile acids. Concentration ranges of 16 faecal metabolites were provided as reference values, showing significant differences in faecal metabolites between high and low sterol converter groups.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Chemistry, Analytical
Yan-Zhen Wang, Yao-Yu Chen, Xin-Ze Wu, Pei-Rong Bai, Na An, Xia-Lei Liu, Quan-Fei Zhu, Yu-Qi Feng
Summary: Gut microbiota-host co-metabolites play a crucial role in mediating communication between the host and gut microbiota, providing nutrients for host cells and regulating the gut microenvironment, which are associated with various diseases. Analysis of these co-metabolites is essential for understanding the host-gut microbiota interaction.
ANALYTICAL CHEMISTRY
(2023)
Article
Gastroenterology & Hepatology
Bo Li, Jun Zhang, Yong Chen, Qixia Wang, Li Yan, Rui Wang, Yiran Wei, Zhengrui You, Yikang Li, Qi Miao, Xiao Xiao, Min Lian, Weihua Chen, Dekai Qiu, Jingyuan Fang, M. Eric Gershwin, Ruqi Tang, Xiong Ma
Summary: The study revealed significant individual variability in the therapeutic effects of cholestyramine in icteric PBC patients. Differences in gut microbial composition and metabolites were observed between patients with superior remission (SR) and inferior remission (IR). Patients in the SR group showed enrichment of specific bacterial species producing short-chain fatty acids (SCFAs), while the IR group exhibited an increase in Klebsiella pneumonia.
Article
Toxicology
Veronique M. P. de Bruijn, Ivonne M. C. M. Rietjens, Hans Bouwmeester
Summary: The present study developed a physiologically based kinetic (PBK) model to predict dose-dependent bile acid (BA) accumulation. The model accurately predicted in vivo BA dynamics and provided estimates of personalized safe therapeutic external dose levels.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Nutrition & Dietetics
Junhui Shen, Li Zhang, Yuanqi Wang, Zhiqing Chen, Jian Ma, Xiaoyun Fang, Undurti N. Das, Ke Yao
Summary: This study investigates the effects of ALA and LA on the metabolism, gut microbiota, and inflammatory and retinal indices in T1DM animals. The results show that ALA and LA have significant benefits in reversing the changes seen in T1DM, suggesting their importance in diabetes mellitus.
FRONTIERS IN NUTRITION
(2022)
Review
Food Science & Technology
Ana-Isabel Mulet-Cabero, Peter J. Wilde
Summary: This review explores the possible mechanisms of calcium in reducing cholesterol, including its interaction with fatty acids and bile acids, and provides clinical evidence. The interaction of calcium with blood lipid metabolism may depend on its multiple roles in lipid digestion in the small intestine and its influence on the solubilization and absorption of cholesterol through its interaction with fatty acids and bile.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Energy & Fuels
Prem Kumar Chaurasiya, Sanjay Kumar Singh, Piyush Kumar Jain, Upendra Rajak, Tikendra Nath Verma, A. K. Azad, Keshavendra Choudhary, Abeer M. Alosaimi, Anish Khan
Summary: This study investigates the effect of corrugations on the outer and inner surface of the inner tube in a double pipe heat exchanger through numerical simulation. The results show that the externally corrugated inner tube provides better heat transfer efficiency compared to the internally corrugated tube.
ENERGY SOURCES PART A-RECOVERY UTILIZATION AND ENVIRONMENTAL EFFECTS
(2023)
Article
Materials Science, Multidisciplinary
Vandna Rani, Monika Malhotra, Shilpa Patial, Sonali Sharma, Pardeep Singh, Aftab Aslam Parwaz Khan, Sourbh Thakur, Pankaj Raizada, Tansir Ahamad, Abdullah M. Asiri
Summary: Molybdenum trioxide (MoO3) photocatalyst has gained considerable attention in the field of photocatalysis due to its high stability, non-toxic nature, and wide specific surface area. However, its weak visible-light absorption capability hinders further progress, primarily due to the slow charge transfer mechanism. The use of Z-scheme heterostructures has significantly improved the photocatalytic performance of MoO3 by enhancing the charge transfer pathway and visible-light utilization. This review provides a comprehensive understanding of the Z-scheme mechanism and discusses various Z-scheme-based MoO3 composites, highlighting their potential applications and future research directions.
MATERIALS CHEMISTRY AND PHYSICS
(2023)
Article
Engineering, Environmental
Akanksha Chauhan, Anita Sudhaik, Pankaj Raizada, Aftab Aslam Parwaz Khan, Arachna Singh, Quyet Van Le, Van -Huy Nguyen, Tansir Ahamad, Sourbh Thakur, Pardeep Singh, Abdullah M. Asiri
Summary: The rapid growth of population and industries has caused major issues for environmental resources and energy. Environmental pollution is mainly caused by the discharge of hazardous pollutants into water, leading to a lack of access to clean water. Photocatalysis, particularly using Zinc selenide (ZnSe), has shown to be effective in improving the environment. This review focuses on the structural and optoelectronic properties of ZnSe and its applications in pollutant degradation and water purification, highlighting various strategies to enhance its photocatalytic activity.
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
(2023)
Article
Biochemistry & Molecular Biology
Elyasa Mustafa Elfaki, Hassan H. Alhassan, Mehnaz Kamal, Maher M. Al-Enazi, Malik Abdul Rub, Abdullah M. Asiri, Maroof Ali, Hadi M. Marwani, Salem Hussain Alharethi, Maha Moteb Alotaibi, Naved Azum
Summary: Tyrosine-protein kinase CSK, also known as C-terminal Src kinase (CSK), plays important roles in regulating diverse cellular processes and pathways, including cell growth, differentiation, migration, and immune responses. Aberrant expression of CSK has been associated with various diseases, such as cancer and autoimmune disorders. This study conducted a structure-based virtual screening of phytochemicals to identify potential CSK inhibitors. Two hits (Shinpterocarpin and Justicidin B) were selected based on their druglike properties and binding affinity towards CSK. Molecular dynamics simulations further confirmed their potential as selective CSK inhibitors.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Physical
Malik Abdul Rub, Farah Khan, Naved Azum, Hadi M. Marwani, Abdullah M. Asiri, Khalid A. Alamry
Summary: In this study, the impact of cationic surfactant DMDEABr on the micellization of PMH was investigated using surface tensions, UV, and FT-IR methods. Synergistic behavior between DMDEABr and PMH was observed in all media. The presence of fructose and NaCl affected the cmc of PMH + DMDEABr. Interaction parameters showed attractive synergy between PMH and DMDEABr. The findings have implications for drug delivery systems.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Polymer Science
Muhammad Tariq Saeed Chani, Khasan S. Karimov, Tahseen Kamal, Noshin Fatima, Mohammed M. Rahman, Abdullah M. Asiri
Summary: Polymeric rubber and organic semiconductor H2Pc-CNT composite-based shockproof deformable infrared radiation (IR) sensors were fabricated using a rubbing-in technique. The sensors showed decreased resistance and impedance when exposed to IR irradiation, and the temperature coefficients of resistance (TCR) were 1.2 and 1.1 for the surface-type and sandwich-type sensors, respectively. The high TCR value and novel composition of the H2Pc-CNT composite make these devices attractive for bolometric applications, and their easy fabrication and low-cost materials make them commercially viable.
Article
Chemistry, Physical
Tahir Ali Sheikh, Abdullah M. Asiri, Amna Siddique, Hadi M. Marwani, Md. Rezaur Rahman, Muhammad Nadeem Akhtar, Mohammed M. Rahman
Summary: A novel electrochemical current-potential (I-V) approach was developed using a highly calcined binary metal oxide (Er2O3@NiO) semiconductor nanocomposite to detect and degrade toxic chemicals in aqueous medium. The modified glassy carbon electrode based on this semiconductor nanocomposite showed selectivity towards m-tolyl hydrazine (m-Tolyl HDZN) and good affinity towards other interfering toxic chemicals. Analytical parameters were optimized and the limit of detection (LOD) for m-Tolyl HDZN was calculated.
Article
Materials Science, Multidisciplinary
H. Mohit, Sanjay Mavinkere Rangappa, Krittirash Yorseng, Suchart Siengchin, Hadi M. Marwani, Anish Khan, Abdullah M. Asiri
Summary: The effect of chemically treated and untreated water hyacinth/pineapple leaf, titanium carbide nanoparticles, Innegra, and carbon fabric reinforcement on the characteristics of polyester hybrid composites was studied. The chemically treated fibers showed excellent bonding with the fillers and textiles, as observed from various analysis techniques. The use of artificial neural network (ANN) for modeling the material characteristics was also investigated in this study.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2023)
Article
Engineering, Multidisciplinary
Rameez Ahmad Aftab, Sadaf Zaidi, Aftab Aslam Parwaz Khan, Mohd Arish Usman, Anees Y. Khan, Muhammad Tariq Saeed Chani, Abdullah M. Asiri
Summary: This study for the first time uses waste black cardamom as an inexpensive and environmentally friendly adsorbent for removing the Congo Red dye from water. The results show that a removal rate of 96.21% can be achieved under the conditions of pH 6, CR initial concentration of 100 mg/L, dose of 0.1 g, and temperature of 30 degrees Celsius.
ALEXANDRIA ENGINEERING JOURNAL
(2023)
Article
Chemistry, Physical
Malik Abdul Rub, Naved Azum, Sulaiman Y. M. Alfaifi, Md Minhas Hossain Sakib, Md Ackas Ali, Shamim Mahbub, Mohammad A. Halim, Md. Anamul Hoque, Abdullah M. Asiri
Summary: The mixed micellization behavior of the antidepressant drug amitriptyline hydrochloride (AMT) and the nonionic surfactant triton X-165 (TX-165) was thoroughly investigated using various techniques. The interaction between AMT and TX-165 was found to be influenced by different solvents, with the interaction being more pronounced in NaCl solvent compared to aqueous and urea solutions. The formation of mixed micelles of AMT + TX-165 was found to be spontaneous and thermodynamically favorable. Molecular dynamics simulation confirmed the interactions between AMT and TX-165, providing a basis for the development of a drug delivery system.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Physical
Naved Azum, Maroof Ali
Summary: The research focus is on modifying the physicochemical properties of ionic liquids using green co-solvents and characterizing them at the molecular level using spectroscopic techniques. The addition of polyethylene glycols (PEGs) to the IL 2-hydroxyethyl ammonium formate (HEF) alters its solvent properties in a positive way. The solvatochromic absorbance probes reveal interesting non-ideal behavior in the absorbance of Reichardt dye 33, which can be attributed to the high dipolarity/polarizability and hydrogen bond donor ability of the HEF + PEG mixtures.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Physics, Applied
Aftab Aslam Parwaz Khan, Z. Fadil, Pankaj Raizada, Pardeep Singh, Maha Alotaibi, Mohammad Omaish Ansari, Anish Khan, Abdullah M. Asiri, Chaitany Jayprakash Raorane
Summary: A monolayer anthracene-like nanostructure was studied through Monte Carlo simulations to determine its compensation temperature and magnetic hysteresis cycle. The effects of exchange coupling on compensation and transition temperatures were discussed. The study also investigated the magnetic hysteresis cycles and surface of multi-loop hysteresis with respect to strong exchange coupling and temperature parameters. This research has significant implications for multi-state memories and nanotechnology.
Review
Chemistry, Multidisciplinary
Umer Shahzad, Hadi M. Marwani, Mohsin Saeed, Abdullah M. Asiri, Mohammed M. Rahman
Summary: Due to their unique two-dimensional layered microstructure, MXenes are considered promising candidates for addressing energy and environmental issues, thanks to their numerous functionalities on the surface and excellent electrical, thermal, and optical features. Altering the dimensions, structure, surface chemistry, and chemical composition of MXenes can enhance their energy conversion and storage capabilities. Therefore, it is crucial to understand the relationship between structure and property from an applied perspective. This study reviews the synthesis, properties, and potential applications of MXenes and discusses their structural, chemical, optical, mechanical, and thermal properties, as well as their applications in photocatalysis, gas sensing, supercapacitors, electrocatalysis, and environmental remediation. It also highlights the progress and future prospects of MXene-based composites, providing valuable insights for scientists in academia and material sciences.
Article
Environmental Sciences
Amjad E. E. Alsafrani, Waheed A. A. Adeosun, Raja Saad Alruwais, Hadi M. M. Marwani, Abdullah M. M. Asiri, Anish Khan
Summary: This research successfully created an efficient electrochemical sensor by incorporating MOFs into PANI/CNT, which demonstrated good current response and electrocatalytic property towards nitrite. The detection limit for nitrite in drinking water was significantly below the WHO-defined acceptable limit. The electrode also showed practical usability in real samples.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
