Journal
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
Volume 9, Issue 2, Pages 139-147Publisher
ADENINE PRESS
DOI: 10.1177/153303461000900203
Keywords
DNA methylation; Microarray; Next-generation sequencing
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Funding
- NIH [U54 CA113001, R01 CA148818]
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DNA cytosine methylation is a central epigenetic modification which plays critical roles in cellular processes including genome regulation, development and disease. Here, we review current and emerging microarray and next-generation sequencing based technologies that enhance our knowledge of DNA methylation profiling. Each methodology has limitations and their unique applications, and combinations of several modalities may help build the entire methylome. With advances on next-generation sequencing technologies, it is now possible to globally map the DNA cytosine methylation at single-base resolution, providing new insights into the regulation and dynamics of DNA methylation in genomes.
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