Article
Gastroenterology & Hepatology
Amy L. Hamilton, Peter De Cruz, Emily K. Wright, Thierry Dervieux, Anjali Jain, Michael A. Kamm
Summary: This study evaluated the accuracy of a new blood test called Endoscopic Healing Index (EHI) in monitoring the recurrence of Crohn's disease. The results showed that EHI had a high concordance with the Rutgeerts endoscopic score, suggesting its effectiveness as a monitoring method.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Pharmacology & Pharmacy
Beatriz Orts, Ana Gutierrez, Lucia Madero, Laura Sempere, Ruben Frances, Pedro Zapater
Summary: There are differences in the immunological profile and clinical evolution of patients with Crohn's disease according to the anti-TNF dose and serum trough levels.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Laura Maas, Ruiyi Gao, Vivy Cusumano, Ellen Spartz, Reezwana Chowdhury, Mahesh Krishna, Mark Lazarev, Joanna Melia, Florin Selaru, Sowmya Sharma, Berkeley Limketkai, Alyssa Parian
Summary: This study compared the efficacy of infliximab (IFX) and adalimumab (ADA) in healing CD-PAF. The results showed that the IFX group had better clinical response at 6 months and higher biologic persistence. In addition, the study supported the use of concomitant immunomodulator therapy for CD-PAF healing and remission.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Bonita Gu, Kavya Venkatesh, Astrid-Jane Williams, Watson Ng, Crispin Corte, Ali Gholamrezaei, Simon Ghaly, Wei Xuan, Sudarshan Paramsothy, Susan Connor
Summary: Maintenance infliximab and adalimumab trough levels are associated with perianal fistula healing in CD. Patients who achieved fistula healing had significantly higher drug trough levels compared to those who did not.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Shintaro Akiyama, Akihiro Yamada, Jacob E. Ollech, Yuga Komaki, Fukiko Komaki, Joel Pekow, Sushila R. Dalal, Russell D. Cohen, David T. Rubin, Atsushi Sakuraba
Summary: This study aimed to assess postoperative outcomes and validate the simple endoscopic score to predict Crohn's disease (CD) patients' disease-related outcomes. The findings showed that patients with colon-dominant disease had a higher risk of postoperative clinical recurrence, and SES-CD was effective in predicting postoperative clinical recurrence in CD patients.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Gastroenterology & Hepatology
Alessandro Ble, Cecilia Renzulli, Fabio Cenci, Maria Grimaldi, Michelangelo Barone, Rocio Sedano, Joshua Chang, Tran M. Nguyen, Malcolm Hogan, Guangyong Zou, John K. MacDonald, Christopher Ma, William J. Sandborn, Brian G. Feagan, Emilio Merlo Pich, Vipul Jairath
Summary: The study found a significant association between endoscopic recurrence and subsequent clinical recurrence in postoperative Crohn's disease patients, supporting the use of endoscopic recurrence as a monitoring tool for disease activity and a primary endpoint in clinical trials.
JOURNAL OF CROHNS & COLITIS
(2022)
Review
Gastroenterology & Hepatology
Fadi H. Mourad, Rami G. Maalouf, Roni Aoun, Paulo Gustavo Kotze, Jana G. Hashash
Summary: A review of the literature found promising results regarding the use of vedolizumab and ustekinumab in preventing and treating postoperative Crohn's disease. However, additional controlled studies comparing these new biologics with anti-tumor necrosis factor agents are necessary.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Gabriele Dragoni, Mariangela Allocca, Paer Myrelid, Nurulamin M. Noor, Nassim Hammoudi, Yves Panis, Marc Ferrante
Summary: This article describes the different methodologies used to report postoperative recurrence in patients with Crohn's disease, including endoscopic, histological, radiological, biochemical, clinical, and surgical approaches. The potential benefits and limitations of these methods, as well as the optimal timing of evaluation, are reviewed.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Lalin Navaratne, Katherine-Helen Hurndall, Daniel M. Richardson, Robert Stephenson, Niall Power, Holly Gillott, Susana Ruiz Sanchez, Kuresh Khodatars, Christopher L. H. Chan
Summary: This study investigated the risk factors for symptomatic anastomotic postoperative recurrence in patients with ileo-colonic Crohn's disease. The study found that patients diagnosed at age <17 years and with gastrointestinal involvement >30 cm were at increased risk of symptomatic anastomotic postoperative recurrence.
COLORECTAL DISEASE
(2021)
Review
Immunology
Rirong Chen, Jieqi Zheng, Chao Li, Qia Chen, Zhirong Zeng, Li Li, Minhu Chen, Shenghong Zhang
Summary: This systematic review evaluates existing models for predicting postoperative recurrence of Crohn's disease and finds that prognostic models have great potential for assessing the risk of recurrence. However, further validation is needed for the reliability and applicability of existing models.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Marion Schaefer, Valerie Laurent, Aurelie Grandmougin, Lucine Vuitton, Arnaud Bourreille, Amandine Luc, Isabelle Clerc-Urmes, Xavier Orry, Eric Frampas, Marjolaine De Billy, Lieven Pouillon, Catherine Le Berre, Claire Gay, Jeremy Meyer, Cedric Baumann, Laurent Peyrin-Biroulet
Summary: A magnetic resonance imaging-based index was developed and validated to predict Crohn's disease postoperative recurrence. The index demonstrated high accuracy and reliability in predicting postoperative recurrence of CD. The MONITOR index can be used in clinical practice to predict the POR of CD.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Peter De Cruz, Amy L. Hamilton, Kathryn J. Burrell, Alexandra Gorelik, Danny Liew, Michael A. Kamm
Summary: The study found that the combination of ulcer depth and circumference at the anastomosis at 6 months postoperatively was associated with endoscopic recurrence at 18 months. Based on these two parameters, a POCER postoperative index was established to identify patients who may require more intensive therapy.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Gastroenterology & Hepatology
Vincent Joustra, Joris van Sabben, Eline van der Does de Willebois, Marjolijn Duijvestein, Nanne de Boer, Jeroen Jansen, Jarmila van der Bilt, Wytze Lameris, Willem Bemelman, Christianne Buskens, Geert D'Haens
Summary: Immediate prophylactic treatment can reduce endoscopic postoperative recurrence rates in high-risk patients within 1 year, but the effect is not significant in low-risk patients. There is no significant difference in clinical postoperative recurrence within 3 years between prophylactic and endoscopy-driven treatment in both high-risk and low-risk patients, but there may be a cumulative effect in high-risk patients with multiple risk factors.
JOURNAL OF CROHNS & COLITIS
(2023)
Review
Gastroenterology & Hepatology
Eun Sil Kim, Ben Kang
Summary: The selection of biologic agents for pediatric Crohn's disease should be done carefully, as currently only infliximab and adalimumab are approved for use in children. Lack of comparison trials in pediatric patients necessitates the extrapolation of adult data. From a pharmacokinetic perspective, infliximab may be more advantageous in high inflammatory burden, while adalimumab may be better in sustaining remission during maintenance phase. Factors such as clinical indications, disease behavior, efficacy, safety, immunogenicity, patient preference, and compliance should be considered when choosing anti-TNF therapy.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Medicine, General & Internal
Giuseppe Frieri, Marco Valvano, Sara Frassino, Susanna Faenza, Nicola Cesaro, Gianfranco Amicucci, Rosa Manetta, Angelo Viscido, Giovanni Latella
Summary: About 50% of CD patients undergo intestinal resection, and 40% of those experience postoperative recurrence within 5 years. This case series aimed to evaluate the incidence of recurrence in CD patients with high risk and prophylactic treatment using Vedolizumab. Magnetic resonance enterography was used to assess the patients after surgical resection.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Gastroenterology & Hepatology
Antonio Tursi, Giovanni Brandimarte, Francesco Di Mario, Arnaldo Andreoli, Maria Laura Annunziata, Marco Astegiano, Maria Antonietta Bianco, Luigi Buri, Giovanni Camrnarota, Erminio Capezzuto, Fausto Chilovi, Massimo Cianci, Rita Conigliaro, Giuseppe Del Favero, Luigi Di Cesare, Michela Di Fonzo, Walter Elisei, Roberto Faggiani, Ferruccio Farroni, Giacomo Forti, Bastianello Germana, Gian Marco Giorgetti, Maurizio Giovannone, Piera Giuseppina Lecca, Silvano Loperfido, Riccardo Marmo, Piero Morucci, Giuseppe Occhigrossi, Antonio Penna, Alfredo Francesco Rossi, Antonio Spadaccini, Costantino Zampaletta, Maurizio Zilli, Angelo Zullo, Carmelo Scarpignato, Marcello Picchio
DIGESTIVE DISEASES
(2015)
Letter
Gastroenterology & Hepatology
Antonio Tursi, Cosimo D. Inchingolo, Marcello Picchio, Walter Elisei, Francesca Mangiola, Giovanni Gasbarrini
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2015)
Article
Gastroenterology & Hepatology
Antonio Tursi, Walter Elisei, Marcello Picchio, Gian M. Giorgetti, Giovanni Brandimarte
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2015)
Article
Gastroenterology & Hepatology
Antonio Tursi, Walter Elisei, Marcello Picchio, Giacomo Forti, Antonio Penna, Cosimo Damiano Inchingolo, Rosanna Nenna, Giovanni Brandimarte
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2015)
Review
Immunology
GianMarco Giorgetti, Giovanni Brandimarte, Federica Fabiocchi, Salvatore Ricci, Paolo Flamini, Giancarlo Sandri, Maria Cristina Trotta, Walter Elisei, Antonio Penna, Piera Giuseppina Lecca, Marcello Picchio, Antonio Tursi
JOURNAL OF IMMUNOLOGY RESEARCH
(2015)
Article
Gastroenterology & Hepatology
Antonio Tursi, Walter Elisei, Marcello Picchio, GianMarco Giorgetti, Giovanni Brandimarte
DIGESTIVE DISEASES AND SCIENCES
(2015)
Review
Surgery
Marcello Picchio, Alessandro De Cesare, Annalisa Di Filippo, Martina Spaziani, Erasmo Spaziani
UPDATES IN SURGERY
(2019)
Article
Biochemistry & Molecular Biology
Giammarco Mocci, Giorgia Bodini, Leonardo Allegretta, Alessia Immacolata Cazzato, Stefania Chiri, Giovanni Aragona, Patrizia Perazzo, Antonio Ferronato, Maria Giovanna Graziani, Cristiano Pagnini, Costantino Zampaletta, Camilla Graziosi, Marcello Picchio, Walter Elisei, Giovanni Maconi, Antonio Tursi
Summary: This study compared the efficacy and safety of GP2017 and its originator in IBD patients in a real-life setting, and the results showed that both GP2017 and its originator were equally effective and safe for the treatment of IBD.
Article
Surgery
Erasmo Spaziani, Annalisa Di Filippo, Piero Francioni, Martina Spaziani, Alessandro De Cesare, Marcello Picchio
ACTA CHIRURGICA BELGICA
(2018)
Meeting Abstract
Gastroenterology & Hepatology
Antonio Tursi, Walter Elisei, Marcello Picchio, GianMarco Giorgetti, Paola Mastromarino, Daniela Capobianco, Alfredo Miccheli, Michela Di Fonzo, Giovanni Brandimarte
Meeting Abstract
Gastroenterology & Hepatology
Antonio Tursi, Giovanni Brandimarte, Francesco Di Mario, Walter Elisei, Roberto Faggiani, Costantino Zampaletta, Giacomo Forti, Antonio Penna, Piera Giuseppina Lecca, Rudi De Bastiani, Marcello Picchio, Carmelo Scarpignato
Article
Surgery
Erasmo Spaziani, Marcello Picchio, Annalisa Di Filippo, Ettore Greco, Alessandra Cerioli, Maurizio Maragoni, Giuliano Facci, Pierino Lucarelli, Giusppe Marino, Franco Stagnitti, Piero Narilli
ANNALI ITALIANI DI CHIRURGIA
(2015)
Meeting Abstract
Medicine, General & Internal
A. Tursi, G. Brandimarte, F. Di Mario, M. L. Annunziata, M. A. Bianco, R. Conigliaro, W. Elisei, R. Faggiani, G. Forti, P. G. Lecca, A. Penna, A. Spadaccini, C. Zampaletta, R. Colucci, R. De Bastiani, L. Di Cesare, M. Di Fonzo, E. Goni, L. Ferrini, M. G. Graziani, G. Latella, F. Pigo, G. Rotondano, G. Schiaccianoce, M. Picchio, C. Scarpignato, P. Portincasa
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2015)
Meeting Abstract
Gastroenterology & Hepatology
A. Tursi, W. Elisei, M. Picchio, A. Penna, G. Giorgetti, G. Brandimarte
JOURNAL OF CROHNS & COLITIS
(2015)
Meeting Abstract
Surgery
P. Lucarelli, M. Picchio, A. Di Filippo, F. De Angelis, E. Spaziani
BRITISH JOURNAL OF SURGERY
(2015)