Article
Infectious Diseases
Oladeji Bamidele, Abdulmojeed Yakubu, Ehase Buba Joseph, Tunde Adegoke Amole
Summary: There is a high prevalence of antibiotic resistance among bacterial isolates from smallholder poultry in the Guinea Savanna agro-ecological zone of Nigeria. Salmonella spp. and Escherichia coli are the most prevalent species with multi-drug resistance. The use of antibiotics significantly influences the prevalence of bacterial species.
Article
Environmental Sciences
Weitao Shen, Yu Chen, Ning Wang, Ping Wan, Zhenyan Peng, Huajin Zhao, Wei Wang, Lilin Xiong, Shenghu Zhang, Ran Liu
Summary: This study analyzed the removal capacity of antibiotics, antibiotic resistance determinants, and bacteria in sewage treatment plants and their impact on environmental waters. The results showed that the removal capacity of bacteria was poor in summer, and the concentration of fluoroquinolone was higher in the effluent. Furthermore, the study found that the relationship between these pollutants differed between summer and winter.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2022)
Article
Infectious Diseases
Nityanand Jain, Inese Jansone, Tatjana Obidenova, Raimonds Simanis, Janis Meisters, Dagnija Straupmane, Aigars Reinis
Summary: This study conducted a retrospective analysis of microbiological data from a large public hospital in Latvia from 2017 to 2020, investigating antimicrobial resistance trends for 19 gram-negative bacterial genera. It found that carbapenems were most effective against GNBs while some bacteria showed significant increases in resistance rates against certain antibiotics. Despite lower prescription levels of penicillin group antimicrobials compared to the European average, GNBs exhibited high average resistant rates, indicating the role of ESBL+ isolates in resistance rates. Constant vigilance and proper infection control measures are necessary to track emerging trends in AMR in GNBs.
Article
Microbiology
Linsey Donner, Zachery R. Staley, Jonathan Petali, Jodi Sangster, Xu Li, Wayne Mathews, Daniel Snow, Adina Howe, Michelle Soupir, Shannon Bartelt-Hunt
Summary: One Health field-based approaches are needed to study the linkage between antibiotics and bacterial antibiotic resistance genes (ARGs) in the environment. Water samples from two Nebraska watersheds influenced by wastewater effluent and agricultural runoff were tested, and ARGs associated with the presence of antibiotics were detected in Gram-negative bacteria through whole-genome sequencing and antimicrobial susceptibility testing.
MICROBIOLOGY SPECTRUM
(2022)
Article
Microbiology
Elyse J. Roach, Tsuyoshi Uehara, Denis M. Daigle, David A. Six, Cezar M. Khursigara
Summary: Gram-negative bacteria producing carbapenemases are resistant to beta-lactam antibiotics, posing a significant health risk. Taniborbactam is an investigational broad-spectrum beta-lactamase inhibitor effective against serine- and metallo-beta-lactamases, including KPC. This study demonstrated the effectiveness of taniborbactam in restoring the antibacterial activity of cefepime against KPC-3-producing Escherichia coli, highlighting its potential in combating beta-lactamase-mediated antibiotic resistance.
MICROBIOLOGY SPECTRUM
(2021)
Review
Microbiology
Tanzeel Zohra, Muhammad Numan, Aamer Ikram, Muhammad Salman, Tariq Khan, Misbahud Din, Ayesha Farooq, Afreenish Amir, Muhammad Ali
Summary: Antimicrobial resistance is a growing silent pandemic, with multidrug-resistant strains threatening public health improvement and posing challenges in clinical practice. Understanding resistance mechanisms and developing new antimicrobial agents and alternative tools are crucial in combating this issue.
Review
Biotechnology & Applied Microbiology
Nayanika Chakraborty, Diksha Jha, Indrajit Roy, Pradeep Kumar, Shailendra Singh Gaurav, Kalisvar Marimuthu, Oon-Tek Ng, Rajamani Lakshminarayanan, Navin Kumar Verma, Hemant K. Gautam
Summary: With the increment in antimicrobial resistance, the world is on the brink of a post-antibiotic era. The current COVID-19 pandemic is expected to exacerbate the situation due to the lack of new antimicrobial drugs. Nanoscale materials have the potential to effectively treat deadly pathogens and avoid the development of antimicrobial resistance.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Medicinal
Ibrahim Waziri, Mustafa A. Isa, Molahlehi Sonopo, D. Bradley G. Williams, Alfred Muller
Summary: The study synthesized N-phenyl-N-nitroso hydroxylamine and its derivatives, which showed activity against a range of bacteria, particularly Gram-positive species. Toxicity studies on the lead compound indicated insignificant effects on healthy cell lines. Molecular docking studies helped identify possible binding modes of the compound and confirmed results obtained from in vitro and MIC studies.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Infectious Diseases
Lenka Doubravska, Miroslava Htoutou Sedlakova, Katerina Fiserova, Vendula Pudova, Karel Urbanek, Jana Petrzelova, Magdalena Roderova, Katerina Langova, Kristyna Mezerova, Pavla Kucova, Karel Axmann, Milan Kolar
Summary: This observational retrospective study analyzed the changes in bacterial pathogens and their resistance to antibiotics among intensive care patients in a Czech hospital during the COVID-19 pandemic. The study found that there were shifts in the distribution and resistance of bacterial pathogens, possibly due to antibiotic selection pressure and clonal spread of bacteria.
Article
Infectious Diseases
Patrick Muinde, John Maina, Kelvin Momanyi, Victor Yamo, John Mwaniki, John Kiiru
Summary: There is a growing problem of bacterial resistance to antibiotics globally, jeopardizing the effectiveness of essential antimicrobials in reducing disease mortality and morbidity. Bacteria in animals are believed to serve as reservoirs of resistance genes that can be transmitted to humans through the food chain. A study in Kenya examined the resistance patterns of bacteria in pork and poultry meat samples from leading retail outlets, and found high contamination rates and a significant proportion of multidrug-resistant isolates, including resistance to critically important antimicrobials for human and veterinary medicine. It is crucial to raise awareness on the proper use of antibiotics and implement preventive measures to reduce the burden of disease.
Review
Biochemistry & Molecular Biology
Aleksandra Baran, Aleksandra Kwiatkowska, Leszek Potocki
Summary: Despite the development of medicine, antibiotics are still the first choice for patients with infectious disorders. However, the widespread availability and overprescription of antibiotics has led to an increase in multidrug-resistant microbes. Understanding the interaction between antibiotic mechanisms and bacterial defense strategies is crucial for developing new drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biotechnology & Applied Microbiology
Christopher Mutuku, Zoltan Gazdag, Szilvia Melegh
Summary: Antimicrobial pharmaceuticals are considered as emergent micropollutants that can have significant eco-toxicological effects even at low concentrations. The lack of standardized regulations for monitoring antibiotic content in environmental water quality standards leads to the indiscriminate discharge of antimicrobials into urban wastewater treatment facilities. This can result in the development of antibiotic resistance in bacteria and potential health consequences. The emergence of multiple antibiotic-resistant bacteria in untreated hospital effluents and wastewater treatment plants is linked to continuous exposure to antimicrobials. Understanding the correlation between environmental exposure to antibiotics and the evolution and spread of resistant bacteria is crucial for formulating mitigation measures.
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
(2022)
Review
Medicine, Research & Experimental
Asuka Joy Tobuse, Chee Wei Ang, Keng Yoon Yeong
Summary: With the continuous evolution of bacteria, the global health threat of antimicrobial resistance, which causes millions of deaths annually, is becoming increasingly serious. While relying on antibiotics as the primary treatment method has its advantages, effective alternatives against some drug-resistant bacteria are still lacking in the pharmaceutical market. In recent years, vaccinology has gained significant attention in scientific research, and with the advancement of technology, vaccine research has become faster and more efficient. Although less discussed, bacterial vaccines are a feasible strategy to combat antimicrobial resistance. Some vaccines have shown promising results with good efficacy against numerous multidrug-resistant strains of bacteria. This review aims to discuss the findings from studies utilizing reverse vaccinology for the development of vaccines against multidrug-resistant bacteria, as well as provide a summary of multi-year bacterial vaccine studies in clinical trials. The advantages of reverse vaccinology in generating new bacterial vaccines are also highlighted. Meanwhile, the limitations and future prospects of bacterial vaccines are concluded in this review.
Article
Biotechnology & Applied Microbiology
Thomas Brenner, Siyun Wang
Summary: The study found that the Salmonella landscape in the poultry sector in Canada has changed, with an increase in the prevalence of formerly minor serovars such as S. Kentucky and S. Reading. The researchers also identified differences between serovars that could influence their survival in different ecological environments.
Article
Biochemistry & Molecular Biology
Akanksha Rajput, Kailash T. Bhamare, Anamika Thakur, Manoj Kumar
Summary: Biofilms are a major cause of antibiotic resistance due to their ability to act as a physical barrier against the immune system and drugs. A machine learning technique called 'anti-Biofilm' was developed to identify and analyze small molecules that inhibit biofilm formation. The algorithm was trained using experimental data and the Support Vector Machine performed the best, demonstrating a correlation coefficient of 0.75. The predictive models were implemented as a user-friendly web server, offering a comprehensive platform for identifying effective anti-biofilm agents.
JOURNAL OF MOLECULAR BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Muntaha S. Al-Khdour, Omar F. Khabour, Laith N. Al-Eitan, Karem H. Alzoubi
Summary: The study found that nedaplatin caused genotoxic effects in human lymphocytes, but pretreatment with Vit E could reduce this toxicity.
DRUG AND CHEMICAL TOXICOLOGY
(2023)
Article
Neurosciences
Karem H. Alzoubi, Abdulsalam M. Halboup, Omar F. Khabour, Mahmoud A. Alomari
Summary: This study investigated the modulation of waterpipe smoking-induced memory impairment by the combined effect of vitamin E and swimming exercise. The results showed that the combination of vitamin E and swimming exercise could prevent waterpipe smoking-induced memory impairment and protect against oxidative stress in the hippocampus.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Article
Biochemistry & Molecular Biology
Alaa Fahmawi, Mohammad S. Khalifeh, Karem H. Alzoubi, Abeer M. Rababa'h
Summary: Sleep deprivation, both acute and chronic, has significant effects on immune factors, with changes observed in IL-1 beta, IL-9, and TNF-alpha levels.
CURRENT MOLECULAR PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Karem Alzoubi, Karim Alkadhi
Summary: This study compared thyroidectomy and propylthiouracil (PTU) induced hypothyroidism models in terms of synaptic plasticity and molecular mechanisms of spatial and non-spatial memory. Both models showed identical plasma levels of thyroid stimulating hormone (TSH) and T4, as well as an equal degree of inhibition in synaptic plasticity. Training in both spatial and non-spatial memory tasks increased the levels of P-CaMKII, PKC?, calcineurin, and calmodulin proteins in the hippocampal area CA1 of control and thyroxine-treated hypothyroid rats, but failed to induce such increases in untreated thyroidectomized rats.
CURRENT MOLECULAR PHARMACOLOGY
(2023)
Article
Oncology
Maha Al-Keilani, Mohammad A. Alqudah, Basima Almomani, Moath M. Alrjoub, Batool A. Shhabat, Karem Alzoubi
Summary: This study aimed to investigate the expression levels of GRP78 and its relationship with the angiogenic markers VEGF and CD31. The results showed that GRP78 overexpression was observed in most of the investigated samples. The positive association between VEGF and GRP78 may indicate the proangiogenic role of GRP78 in lung cancer, and the positive association between VEGF and CD31 expression levels suggests that VEGF may cooperate with CD31 to promote angiogenesis in NSCLC.
CURRENT CANCER DRUG TARGETS
(2023)
Article
Medicine, Research & Experimental
Doa'a G. F. Al-U'datt, Carole C. Tranchant, Muhammad Alu'datt, Sara Abusara, Ahmed Al-Dwairi, Mohammad AlQudah, Othman Al-shboul, Roddy Hiram, Yasemin Altuntas, Saied Jaradat, Karem H. Alzoubi
Summary: This study aimed to investigate the effects of cystamine on isoproterenol-induced cardiac fibrosis and dysfunction. The results showed that cystamine administration could reduce cardiac fibrosis, decrease profibrotic marker expression, and protect cardiac function.
Article
Multidisciplinary Sciences
Mahmoud A. A. Alomari, Omar F. F. Khabour, Karem H. H. Alzoubi, Abubakar B. B. Maikano
Summary: A survey conducted during the COVID-19 pandemic found that about 50% of participants who smoke tobacco reported changes in their smoking habits, with a higher prevalence of decreased smoking. Factors such as age, gender, income, and job sector were found to contribute to these changes.
Article
Agriculture, Dairy & Animal Science
Yasser Bustanji, Katia H. Abu Shihab, Waseem El-Huneidi, Mohammad H. Semreen, Eman Abu-Gharbieh, Karem H. Alzoubi, Mohammad A. Y. Alqudah, Ahmad Y. Abuhelwa, Eman Y. Abu-Rish, Hana Bajes, Khaled Obaideen, Islam Hamad, Nelson C. Soares, MoezAlIslam E. Faris
Summary: This study used the Scopus database to analyze and evaluate the bibliometric indicators of global monkeypox research. The results showed that the United States was the most active in terms of researchers and institutions, but there was less global cooperation than anticipated. Fostering international collaboration is crucial for addressing this global threat.
Article
Environmental Sciences
Anan S. S. Jarab, Walid Al-Qerem, Karem H. H. Alzoubi, Shrouq Abu Heshmeh, Ahmad nor Aldin Alzoubi, Tareq L. L. Mukattash, Badi'ah Alazab, Yazid N. Al Hamarneh
Summary: This cross-sectional study aimed to evaluate public perception, satisfaction, expectations, and barriers to utilize the community pharmacy services. The mean age of the participants was 29 (±10) years. The participants showed good perception, satisfaction, and expectations of community pharmacy services, but several barriers were identified, such as higher participants' trust in physicians compared to pharmacists (63.1%) and lack of privacy in the pharmacy (45.7%). Community pharmacists should participate in education and training programs to raise the quality of services provided and rebuild consumer confidence.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2023)
Article
Education, Scientific Disciplines
Samir Al Bashir, Nosayba Al-Azzam, Lina Elsalem, Aya Al Smerat, Husam K. Haddad, Jomana Alsulaiman, Khalid A. Kheirallah, Karem H. Alzoubi
Summary: This study assessed students' experiences of virtual laboratory sessions compared to on-campus sessions. The results showed that more students preferred virtual sessions in histology, pathology, and microbiology laboratories. Some students reported less effort in virtual sessions but had difficulty remembering the instructions given. Gender, major, and year of study also influenced students' experiences.
ADVANCES IN MEDICAL EDUCATION AND PRACTICE
(2023)
Article
Medicine, General & Internal
Anan S. Jarab, Walid Al-Qerem, Shrouq R. Abu Heshmeh, Karem H. Alzoubi, Tareq L. Mukattash, Amal Akour
Summary: This study aimed to evaluate disease activity and explore factors associated with poor disease control in rheumatoid arthritis (RA) patients. A cross-sectional study was conducted in outpatient rheumatology clinics in two teaching hospitals in Jordan. Medication adherence was assessed using a validated questionnaire, and disease activity was assessed using the clinical disease activity index score. The study found that most participants demonstrated moderate to high disease activity, with seronegative RA associated with lower disease activity and medication nonadherence associated with poor RA control. Future research should investigate factors related to medication nonadherence and target these factors in interventions to improve RA control, especially in patients with high disease severity.
ELECTRONIC JOURNAL OF GENERAL MEDICINE
(2023)
Article
Medicine, General & Internal
Sameeha A. Alshelleh, Hussein Alhawari, Ashraf O. Oweis, Karem H. Alzoubi
Summary: Arabic gum, a widely used dietary additive, has been shown to have antioxidant and anti-inflammatory effects. This study found that AG can reduce eGFR in CKD patients, especially in those with diabetes.
ELECTRONIC JOURNAL OF GENERAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Mohammed Zawiah, Fahmi Y. Al-Ashwal, Lobna Gharaibeh, Rana Abu Farha, Karem H. Alzoubi, Khawla Abu Hammour, Qutaiba A. Qasim, Fahd Abrah
Summary: The integration of ChatGPT in clinical training offers potential benefits, but the lack of trust in it for clinical decisions among students indicates the need for collaborative human-ChatGPT decision-making. Further research is crucial to optimize the effective integration of ChatGPT.
JOURNAL OF MULTIDISCIPLINARY HEALTHCARE
(2023)
Article
Health Care Sciences & Services
Abdulsalam M. Halboup, Karem H. Alzoubi, Rana K. Abu-Farha, Sabariah Noor Harun, Ahmed Al-Mohamadi, Mohammed M. Battah, Ammar Ali Saleh Jaber, Sameer Alkubati, Fahmi Y. Al-Ashwal
Summary: The study reveals a low level of public knowledge about monkeypox in Yemen, highlighting the need for targeted educational campaigns to strengthen public health measures and disease control, particularly through social media.
JOURNAL OF MULTIDISCIPLINARY HEALTHCARE
(2023)
Article
Environmental Sciences
Anan S. Jarab, Walid Al-Qerem, Haya Y. Alajlouni, Karem H. Alzoubi, Shrouq Abu Heshmeh, Tareq L. Mukattash, Abdallah Y. Naser, Yazid N. Al Hamarneh
Summary: This study investigated knowledge and attitude towards Drug-Food Interaction (DFI) and found that the participants had moderate knowledge and attitudes about DFI. Factors such as male gender, lower education level, not working in the healthcare sector, and utilizing non-scientific sources of information were associated with lower knowledge about DFI. Health education programs should focus on using reliable scientific sources to enhance awareness about DFIs. Furthermore, healthcare professionals should counsel patients on avoiding DFIs and provide appropriate guidance.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2023)
