Article
Computer Science, Interdisciplinary Applications
Pablo Rodriguez-Belenguer, Karolina Kopanska, Jordi Llopis-Lorente, Beatriz Trenor, Javier Saiz, Manuel Pastor
Summary: In the simulation prediction of drug-induced ventricular arrhythmia, precomputed simulation result matrices can be used to reduce computation time and improve efficiency in predicting biomarkers such as action potential duration (APD90). Machine learning methods are applied to predict simulation results, leading to a decrease in computation time. This approach can be applied in other fields to reduce computational cost.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Khalid Changal, David Paternite, Sean Mack, Spiro Veria, Rehana Bashir, Mitra Patel, Ronak Soni, Muhammad Ali, Tanveer Mir, Mujeeb Sheikh, P. Kasi Ramanathan
Summary: This study found that older age, end-stage renal disease, underlying cardiovascular disease, potential virus mediated cardiac injury, and drugs like hydroxychloroquine/azithromycin contribute to QTc prolongation in COVID-19 patients. The role of ACE inhibitors in preventing QTc prolongation in COVID-19 patients needs further study. Ventricular arrhythmias and mortality were not associated with QTc prolongation in COVID-19 patients.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Environmental Sciences
Elisabetta Bertol, Fabio Vaiano, Antonina Argo, Stefania Zerbo, Claudia Trignano, Simone Protani, Donata Favretto
Summary: Quetiapine is a medication used to treat various mental disorders, but overdose can be life-threatening. A case study of a 75-year-old male who attempted suicide by ingesting a large amount of Quetiapine without other medications was presented, and a complete pharmacokinetic analysis was conducted during his management in the emergency department.
Review
Biochemistry & Molecular Biology
Alessandro Villa, Michal Kuten-Shorrer
Summary: Targeted therapy and immunotherapy have revolutionized cancer treatment, but oral toxicities induced by these therapies remain a concern. These toxicities can manifest as mucosal lesions, salivary gland dysfunction, or orofacial neuropathies, impacting patients' quality of life and clinical outcomes. Further research is needed to better understand and manage these adverse events.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Rossella Reddavid, Simona Dagatti, Caterina Franco, Lucia Puca, Mariano Tomatis, Simona Corso, Silvia Giordano, Maurizio Degiuli
Summary: Despite the addition of molecular therapy in the clinical treatment of advanced and metastatic gastric cancer, the survival benefits of these novel therapies remain rather unclear, possibly due to inaccurate patient selection.
Review
Oncology
Charalampos Aktypis, Maria-Eleni Spei, Maria Yavropoulou, Goran Wallin, Anna Koumarianou, Gregory Kaltsas, Eva Kassi, Kosmas Daskalakis
Summary: This study provides a comprehensive review of the safety profile of biotherapy and molecular targeted therapies in NEN patients, focusing on cardiovascular toxicities. Results indicate that SSAs and TPH inhibitors are safer in terms of overall toxicity, particularly cardiovascular toxicities, compared to mTOR inhibitors and TKIs.
Review
Oncology
Mees D. Egeler, Marieke van Leeuwen, Itske Fraterman, Noelle M. J. van den Heuvel, Annelies H. Boekhout, Julia Lai-Kwon, Erica A. Wilthagen, Hanna Eriksson, John B. Haanen, Sofie Wilgenhof, Paolo A. Ascierto, Alexander C. J. van Akkooi, Lonneke V. van de Poll-Franse
Summary: This systematic scoping review compares the toxicities experienced by patients receiving immune checkpoint inhibitors (ICIs) or targeted therapy (TT) for stage III and IV melanoma. The results show that ICIs have lower rates of adverse events (AEs) compared to TT, but they are associated with higher rates of long-term or permanent AEs.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Review
Medicine, General & Internal
Rasha Kaddoura, Wafer A. A. Dabdoob, Khalid Ahmed, Mohamed A. A. Yassin
Summary: Tyrosine kinase inhibitors (TKIs) have greatly improved the treatment of chronic myeloid leukemia (CML), but they can cause serious cardiopulmonary toxicities, such as vascular adverse events, QT prolongation, heart failure, pleural effusion, and pulmonary arterial hypertension. Currently, there are no dedicated clinical management guidelines for TKI-induced toxicities. This review aims to discuss these cardiopulmonary toxicities and proposes a practical guide for their management.
FRONTIERS IN MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Xin Hui S. Chan, Palang Chotsiri, Rebecca A. Capel, James Pike, Borimas Hanboonkunupakarn, Sue J. Lee, Maryam Hanafiah, Yan Naung Win, Maegan A. Cremer, Jean-Rene Kiechel, Bernhards Ogutu, Walter R. J. Taylor, Rebecca-Ann B. Burton, Joel Tarning, Nicholas J. White
Summary: Amodiaquine and desethylamodiaquine have concentration-dependent effects on heart rate, blood pressure, and ventricular repolarization.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Peripheral Vascular Disease
Satoshi Yamaguchi, Takayuki Hamano, Tatsufumi Oka, Yohei Doi, Sachio Kajimoto, Seiichi Yasuda, Karin Shimada, Ayumi Matsumoto, Yusuke Sakaguchi, Kazunori Inoue, Isao Matsui, Akira Suzuki, Yoshitaka Isaka
Summary: This study found that ECG parameters were associated with subsequent cardiovascular disease in dialysis patients, with the sum of abnormalities in PR, QRS, and QT intervals predicting nonatherosclerotic CVD. The predictive value of LVH for atherosclerotic CVD decreased over time.
HYPERTENSION RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Signe Caksa, Usman Baqai, Andrew E. Aplin
Summary: Melanoma, a growing cancer, is currently treated with targeted inhibitors in the MAPK pathway, but drug resistance limits its effectiveness. However, new applications and combinations with other therapies may provide hope for melanoma treatment.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Oncology
Rachel S. Goodman, Lorenza Di Guardo, Andrea Maurichi, Brendan Kirwin, Adnan Khattak, Vito Vanella, Joanna Lee, Aleigha Lawless, Juliane Czapla, Andrea Spagnoletti, Margherita Ambrosini, Elisabeth Livingstone, Georgina V. Long, Ryan J. Sullivan, Matteo S. Carlino, Victoria Atkinson, Claudia Trojanello, Paolo A. Ascierto, Dirk Schadendorf, Lydia Warburton, Alexander M. Menzies, Mario Santinami, Douglas B. Johnson
Summary: This retrospective multicenter cohort study evaluated patients who received BRAF/MEK inhibitors and had a progression-free survival of 4 years or more, and found that over 75% of patients still had durable antitumor responses after nearly 8 years of median follow-up. Similar results were observed in patients who discontinued therapy. Long-term toxicities were uncommon and low-grade.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Pharmacology & Pharmacy
Anna Egorova, Mariya Petrosyan, Marianna Maretina, Elena Bazian, Iuliia Krylova, Vladislav Baranov, Anton Kiselev
Summary: In this study, the potential of RGD1-R6 peptide carrier as a non-viral vehicle for targeted siRNA delivery to endothelial cells was evaluated. The results showed that the modified siRNA complexes had higher gene silencing efficiency and lower endothelial cell migration compared to unmodified complexes. In a rat endometriosis model, the combination therapy of the carrier with anti-VEGF siRNA complexes significantly inhibited implant growth and VEGFA gene expression, comparable to Dienogest.
Article
Critical Care Medicine
Roi Bar Cohen, Matthew Dai, Anthony Aizer, Chirag Barbhaiya, Connor Peterson, Scott Bernstein, David S. Park, Michael Spinelli, Larry A. Chinitz, Lior Jankelson
Summary: The QTc/JTc interval is significantly and independently prolonged after sudden cardiac arrest, regardless of known QT prolonging triggers. Normalization of the QTc is expected only after day 6 of hospitalization. Assessment of the QTc for determining the etiology of arrest or monitoring the effect of QT prolonging medications may be unreliable.
Article
Chemistry, Medicinal
Osama M. Soltan, Mai E. Shoman, Salah A. Abdel-Aziz, Atsushi Narumi, Hiroyuki Konno, Mohamed Abdel-Aziz
Summary: Protein kinases have emerged as crucial targets in cancer treatment, with the design of multi-target drugs showing potential to enhance efficacy, reduce side effects, and maintain pharmacokinetic properties. Hybrid drugs combining kinase inhibitors with conventional chemotherapeutics or targeted therapies present a new approach in cancer treatment.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Cardiac & Cardiovascular Systems
Jennifer Cautela, Franck Rouby, Joe-Elie Salem, Joachim Alexandre, Ugo Scemama, Charles Dolladille, Ariel Cohen, Franck Paganelli, Stephane Ederhy, Franck Thuny
CANADIAN JOURNAL OF CARDIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Lili Zhang, Magid Awadalla, Syed S. Mahmood, Anju Nohria, Malek Z. O. Hassan, Franck Thuny, Daniel A. Zlotoff, Sean P. Murphy, James R. Stone, Doll Lauren Alexandra Golden, Raza M. Alvi, Adam Rokicki, Maeve Jones-O'Connor, Justine Cohen, Lucie M. Heinzerling, Connor Mulligan, Merna Armanious, Ana Barac, Brian J. Forrestal, Ryan J. Sullivan, Raymond Y. Kwong, Eric H. Yang, Rongras Damrongwatanasuk, Carol L. Chen, Dipti Gupta, Michael C. Kirchberger, Javid J. Moslehi, Otavio R. Coelho-Filho, Sarju Ganatra, Muhammad A. Rizvi, Gagan Sahni, Carlo G. Tocchetti, Valentina Mercurio, Michael Mahmoudi, Donald P. Lawrence, Kerry L. Reynolds, Jonathan W. Weinsaft, A. John Baksi, Stephane Ederhy, John D. Groarke, Alexander R. Lyon, Michael G. Fradley, Paaladinesh Thavendiranathan, Tomas G. Neilan
EUROPEAN HEART JOURNAL
(2020)
Article
Oncology
Charles Dolladille, Stephane Ederhy, Stephane Allouche, Querntin Dupas, Radj Gervais, Jeannick Madelaine, Marion Sassier, Anne-Flore Plane, Francois Comoz, Ariel Aron Cohen, Franck Roland Thuny, Jennifer Cautela, Joachim Alexandre
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Article
Oncology
Jean-Marie Michot, Ariane Lappara, Jerome Le Pavec, Audrey Simonaggio, Michael Collins, Eleonora De Martin, Francois-Xavier Danlos, Samy Ammari, Cecile Cauquil, Stephane Ederhy, Emmanuel Barreau, Rakiba Belkhir, Amandine Berdelou, Julien Lazarovici, Philippe Chanson, Hassan Izzedine, Andrei Seferian, Christine Le Pajolec, Capucine Baldini, Patricia Martin-Romano, Xavier Mariette, Caroline Robert, Benjamin Besse, Antoine Hollebecque, Andrea Varga, Salim Laghouati, Christine Mateus, Anne-Laure Voisin, Jean-Charles Soria, Christophe Massard, Aurelien Marabelle, Stephane Champiat, Olivier Lambotte
EUROPEAN JOURNAL OF CANCER
(2020)
Article
Cardiac & Cardiovascular Systems
Theo Pezel, Emmanuelle Berthelot, Jean Gauthier, Caroline Chong-Nguyen, Marie C. Iliou, Yves Juilliere, Michel C. Galinier, Pascal De Groote, Florence Beauvais, Fabrice Bauer, Ugo Vergeylen, Barnabas Gellen, Pierre Raphael, Melanie Bezard, Jean-Etienne Ricci, Marie-Claire Boiteux, Louis Bonnefous, Diane Bodez, Etienne Audureau, Thibaud Damy
Summary: A study conducted in 2017 in France found that 36% of heart failure patients were smartphone users, and these users tended to be younger, more frequently male, have a higher educational level, live in cities, and be professionally active. Smartphone users were also less likely to have diabetes, hypertension, atrial fibrillation, or ischemic cardiopathy, but only 22% of patients were actively participating in therapeutic education programs.
ARCHIVES OF CARDIOVASCULAR DISEASES
(2021)
Article
Geriatrics & Gerontology
Emmanuelle Berthelot, Amaury Broussier, Thibaud Damy, Cristiano Donadio, Stephane Cosson, Xavier Rovani, Emmanuel Salengro, Gilles Billebeau, Richard Megbemado, Noomen Rekik, Christian Godreuil, Kevin Richard, Jason Shourick, Patrick Assayag, Joel Belmin, Jean Philippe David, Luc Hittinger
Summary: This study investigated the profile and outcome of elderly patients hospitalized for Acute Heart Failure (AHF) in cardiogeriatrics departments in Val-de-Marne area of Paris. Patients in cardiogeriatrics departments were older, less independent, more often depressed, and had a higher Human Development Index compared to those in cardiology departments, but had similar prognosis in terms of AHF rehospitalization at 90 days.
Article
Cardiac & Cardiovascular Systems
Florence Beauvais, Lamia Tartiere, Theo Pezel, Chloe Motet, Marie-Claude Aumont, Guillaume Baudry, Jean-Christophe Eicher, Michel Galinier, Barnabas Gellen, Julien Guihaire, Damien Legallois, Benoit Lequeux, Delphine Mika, Frederic Mouquet, Muriel Salvat, Charles Taieb, Florian Zores, Emmanuelle Berthelot, Thibaud Damy
Summary: This study examined the type and chronology of the first AHF symptoms before hospitalization and analyzed the French healthcare system pathways before, during, and after hospitalization. Results suggest the need for developing an AHF clinic network to provide adequate care for all HF patients and increase awareness regarding AHF symptoms.
CLINICAL CARDIOLOGY
(2021)
Editorial Material
Oncology
Jordi Remon, Lizza E. L. Hendriks, Benjamin Besse
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
Julie Delorme, Valentin Charvet, Muriel Wartelle, Francois Lion, Bruno Thuillier, Sandrine Mercier, Jean-Charles Soria, Mikael Azoulay, Benjamin Besse, Christophe Massard, Antoine Hollebecque, Loic Verlingue
Summary: The study aimed to predict successful completion of screening and dose-limiting toxicity period in early-phase oncology trials using machine learning. By transforming consultation reports into semantic vectors and clustering them, a model was trained to achieve high performance in predicting patient outcomes.
JCO CLINICAL CANCER INFORMATICS
(2021)
Letter
Geriatrics & Gerontology
Abdelhakim Hacil, Bastien Genet, Patrick Assayag, Patrick Jourdain, Justina Motiejunaite, Jean Philippe David, Christiane Verny, Olivier Hanon, Emmanuelle Berthelot
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2022)
Article
Cardiac & Cardiovascular Systems
Xenia Leahova-Cerchez, Emmanuelle Berthelot, Bastien Genet, Olivier Hanon, Patrick Jourdain
Summary: There is a strong correlation between clinical and inferior vena cava (IVC) evaluation in assessing intravascular congestion in ADHF patients older than 75 years. The concomitant assessment of clinical signs and IVC may prevent depletion-related renal failure.
CLINICAL CARDIOLOGY
(2022)
Article
Oncology
Alexander Drilon, Joshua C. Horan, Anupong Tangpeerachaikul, Benjamin Besse, Sai-Hong Ignatius Ou, Shirish M. Gadgeel, D. Ross Camidge, Anthonie J. van der Wekken, Linh Nguyen-Phuong, Adam Acker, Clare Keddy, Katelyn S. Nicholson, Satoshi Yoda, Scot Mente, Yuting Sun, John R. Soglia, Nancy E. Kohl, James R. Porter, Matthew D. Shair, Viola Zhu, Monika A. Davare, Aaron N. Hata, Henry E. Pelish, Jessica J. Lin
Article
Cardiac & Cardiovascular Systems
Emmanuelle Berthelot, Amaury Broussier, Luc Hittinger, Cristiano Donadio, Xavier Rovani, Emmanuel Salengro, Richard Megbemado, Christian Godreuil, Joel Belmin, Jean Philippe David, Bastien Genet, Thibaud Damy
Summary: Cardiac amyloidosis is a significant risk factor for heart failure patients, leading to higher death and hospital readmission rates compared to those without this condition. This study found that patients with cardiac amyloidosis had elevated heart rate and brain natriuretic peptide levels, and lower blood pressure, weight, and body mass index values upon discharge. Furthermore, cardiac amyloidosis patients experienced higher death and hospital readmission rates, occurring sooner after discharge, highlighting the importance of active management for these patients.
Editorial Material
Oncology
Marco Tagliamento, Jordi Remon, David Planchard, Benjamin Besse
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Respiratory System
Denis Chemla, Emmanuelle Berthelot, Jason Weatherald, Edmund M. T. Lau, Laurent Savale, Antoine Beurnier, David Montani, Olivier Sitbon, Pierre Attal, David Boulate, Patrick Assayag, Marc Humbert, Philippe Herve
Summary: This study compared arterial compliance in different types of pulmonary hypertension patients and found that comparing at fixed mPAP level was more reliable than at fixed PVR level. Further studies are needed to reassess the effects of PAWP on arterial load in the right heart.
