Article
Chemistry, Physical
Yasemin Celik, Ayse Kurt
Summary: Hybrid SERS substrates combining noble metal nanoparticles and graphene-based materials offer a stable and cost-effective platform for SERS analysis, which shows great potential to promote the application of SERS for routine analyses.
APPLIED SURFACE SCIENCE
(2021)
Review
Chemistry, Multidisciplinary
Andrea N. Giordano, Rahul Rao
Summary: The field of ultraviolet surface-enhanced Raman scattering (UV-SERS) has lagged behind its visible and near-infrared counterparts despite its potential advantages. A major challenge is the lack of accessible and reproducible UV-SERS substrates. In this review, we assess the reported UV-SERS substrates based on their composition, morphology, and performance, and discuss the challenges and opportunities in this field. We also explore potential application areas for UV-SERS, such as detecting environmentally and militarily relevant analytes, in situ experimentation, defect engineering, extreme environment materials development, and biosensing.
Article
Chemistry, Physical
Anindita Das, Udit Pant, Cuong Cao, Rakesh S. Moirangthem, Hitesh Bhanudas Kamble
Summary: The proposed work aims to develop a sensitive surface-enhanced Raman spectroscopy (SERS) nano-biosensor using gold-coated polymer nanopyramid arrays as the SERS substrate. The study also investigates the Raman signal enhancement mechanism through electromagnetic simulation and evaluates the potential of the fabricated nanopyramid arrays for low-cost, large scale detection of hazardous compounds at ultra-low concentrations.
Article
Chemistry, Analytical
W. Cheuquepan, S. Hernandez, M. Perez-Estebanez, L. Romay, A. Heras, A. Colina
Summary: Electrochemistry can be used to generate SERS substrates, utilizing the plasmonic properties of nanos-tructures and the chemical mechanism, with time-resolved Raman spectroelectrochemistry providing valuable information. Comparing Au and Ag metals for folic acid detection in drugs, it was found that Ag SERS substrates outperformed Au SERS substrates in complex samples.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Xuefang Gu, Shu Tian, Yiyang Chen, Yuxin Wang, Dandan Gu, Enhui Guo, Ying Liu, Jianguo Li, Anping Deng
Summary: The SERS-based competitive immunoassay for detecting beta-adrenergic agonists was developed using highly ordered gold cavity arrays, achieving high sensitivity and recoveries. Introduction of long DNA concatamers and silver staining can enhance the sensitivity, making it a new efficient and sensitive detection method.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Biochemistry & Molecular Biology
Mohammad Kamal Hossain
Summary: In this study, a conventional silicon wafer was treated to expose terraces within the silicon nanostructures (Si-NSs) and decorated with silver nanoparticles (Ag-NPs) to enhance the surface-enhanced Raman scattering (SERS) activity. The SERS activity of Ag-NPs-decorated Si-NSs was found to be significantly enhanced compared to pristine Si-NSs. Three electromagnetic field models were developed to support experimental observations, indicating that Si-NSs facilitate light confinement and can be cascaded within different Ag-NPs-decorated terraces.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Multidisciplinary
Mohamed A. Ettabib, Almudena Marti, Zhen Liu, Bethany M. Bowden, Michalis N. Zervas, Philip N. Bartlett, James S. Wilkinson
Summary: Waveguide enhanced Raman spectroscopy (WERS) utilizes high-index contrast dielectric waveguides to generate a strong evanescent field for direct identification of biochemical species. Advancements in technology have made portable and high sensitivity WERS Raman systems a realistic possibility.
Article
Biotechnology & Applied Microbiology
Zhouyang Xiang, Mengyun He, Li Li, Jamshed Bobokalonov, Abduvali Dzhonmurodov, Xingxiang Ji
Summary: In this study, a paper-based Au-Ag bimetallic SERS substrate was developed using cellulose fiber/paper-based technology. The substrate, anchored by natural macromolecule-xylan, showed high Raman enhancement performance and reproducibility. It can be used for rapid detection of agricultural product contaminants and pesticide residues on fruit surfaces.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Jeongwon Kim, Sungwoo Lee, Jiwoong Son, Jieun Kim, Hajir Hilal, Minsun Park, Insub Jung, Jwa-Min Nam, Sungho Park
Summary: Rational design of plasmonic colloidal assemblies via bottom-up synthesis is challenging but can demonstrate unprecedented optical properties that are strongly related to the shape and spatial arrangement of the assembly. In this study, plasmonic cyclic Au nanosphere hexamers (PCHs) were successfully synthesized and showed excellent performance in single-particle surface-enhanced Raman scattering signals.
Article
Spectroscopy
Arti Saroj, Uttam Sharma, Santanu Das, Venkatnarayan Ramanathan
Summary: This study explores the potential of non-noble metal substrates for Surface-enhanced Raman spectroscopy (SERS) and prepares a nanoplate beta-Bi2O3/Bi2O2CO3 heterostructure as a novel SERS substrate. The results demonstrate that the SERS signal on this substrate is significantly enhanced by adsorbed probe molecules.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Review
Chemistry, Analytical
Vahid Eskandari, Saeideh Mehmandoust, Zahra Farahani, Negin Poorbeik Mohammad, Amin Hadi
Summary: The special features of liposome-based drug delivery systems have proven useful in overcoming biological and pharmacodynamic challenges. Liposomes, especially those used for targeted drug delivery to pathological tissues, are considered the simplest mimic of biological cells in medicine, attracting the attention of many researchers. Surface-enhanced Raman scattering (SERS) offers nondestructive analysis and high detection sensitivity, making it ideal for single molecular detection. This study reviews recent literature on SERS-based biosensors for enhancing diagnostic and therapeutic platforms, drug delivery systems, and pharmaceutical applications, aiming to aid researchers in making more advanced and successful systems in this sensitive and important field.
VIBRATIONAL SPECTROSCOPY
(2023)
Article
Chemistry, Multidisciplinary
Younju Joung, Kihyun Kim, Seungwoo Lee, Byung-Seon Chun, Sangyeop Lee, Joonki Hwang, Suji Choi, Taejoon Kang, Mi-Kyung Lee, Lingxin Chen, Jaebum Choo
Summary: This study developed a portable surface-enhanced Raman scattering (SERS)-LFA reader based on localized surface plasmon effects to improve the detection sensitivity of commercial LFA strips. Testing 54 clinical samples, the SERS-LFA reader demonstrated a significantly reduced false-negative rate compared to commercial LFA strips.
Article
Nanoscience & Nanotechnology
Seung Mo Lee, Dong Hwan Nam, Dongkyu Lee, Soon Hyuk Lim, Sang Jun Son, Seunghyun Lee
Summary: The study successfully fabricated a highly ordered gold nanoparticle monomer array based on a gold-coated conical anodic aluminum oxide template, creating a ring-shaped hot line between the gold layer and AuNPs for enhanced surface-enhanced Raman scattering signal.
ACS APPLIED NANO MATERIALS
(2021)
Article
Chemistry, Physical
C. K. Chung, C. Y. Yu
Summary: A new type of SERS substrate is proposed, which does not require the use of metal nanoparticles. The substrate is fabricated by electrochemically micromachining aluminum foil to create a roughened surface with randomly-distributed 3D over-etched cavities and nanopores of anodized aluminum oxide (AAO). This SERS substrate demonstrates high analytical enhancement and low detection limit, making it suitable for rapid detection of substances such as methylene blue.
APPLIED SURFACE SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
I. A. Brezestean, N. Tosa, A. Falamas, D. Cuibus, C. M. Muntean, A. Bende, B. Cozar, C. Berghian-Grosan, C. Farcau
Summary: This study reports on the use of self-assembled colloidal nanoparticle films for Surface Enhanced Raman Spectroscopy (SERS) analysis of pesticides. The results demonstrate the high sensitivity and selectivity of this technique, making it suitable for applications in the food industry and environmental monitoring.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Analytical
Qian Wu, Li Tian, Xiangyu Shan, Huiling Li, Chao Li, Juan Lu
Summary: A novel ECL sensor was developed by modifying Fe3CuO4-Ru(bpy)3+ and GO-CdS@ZnS on the electrode for the detection of permethrin. The sensor exhibited high sensitivity and a wide detection range.
Article
Chemistry, Analytical
Tingting Gong, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescent biosensing system for high sensitivity detection of MT was established using a new Ag+-stabilized DNA triplex probe (Ag+-SDTP) combined with catalytic hairpin assembly (CHA) and CRISPR/Cas12a signal enhancements. The sensing method is able to selectively detect MT from other non-specific molecules and can achieve low level detection of MT in diluted human serums, demonstrating its potential for monitoring disease-specific MT biomarker at trace levels.
Article
Chemistry, Analytical
Estrella Sanz Rodriguez, Kyra Wood, Paul R. Haddad, Brett Paull
Summary: This study presents a simple, rapid, and reliable method for determining boron in aqueous solutions using suppressed ion chromatography coupled to electrospray ionisation-triple quadrupole mass spectrometry. The method achieved a low limit of detection and demonstrated excellent analytical performance.
Article
Chemistry, Analytical
Aline Cournut, Paul Moustiez, Yannick Coffinier, Christine Enjalbal, Claudia Bich
Summary: Alzheimer's disease is a major cause of senile dementia and is characterized by the aggregation of neurofibrillary tangles and amyloid plaques in the brain. The A beta 1-42 peptide is considered the primary cause of neurotoxicity due to its insolubility and subsequent aggregation. A beta 1-42 and A beta 1-40 have been identified as relevant biomarkers for AD diagnosis, and SurfaceAssisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) was used to monitor the A beta 1-42/A beta 1-40 ratio without prior sample treatment.
Article
Chemistry, Analytical
Dotse Selali Chormey, Buse Tugba Zaman, Tulay Borahan Kustanto, Sezin Erarpat Bodur, Suleyman Bodur, Elif Ozturk Er, Sezgin Bakirdere
Summary: This review provides an overview of the harmful effects of endocrine disrupting chemicals (EDCs) on human health and introduces the methods for analyzing EDCs. Recent research has focused on using green chemicals, such as deep eutectic solvents (DESs), for microextraction to ensure environmental safety.
Article
Chemistry, Analytical
Yan Zhang, Renfeng Xu, Jingjing Wu, Zhenghong Zhang, Yuhuang Wang, Hongqin Yang, Sheng Zhang
Summary: This study visualized the pore-like structures in prostate cancer cell membranes after treatment with the anticancer drug paclitaxel, demonstrating its mechanism of action related to oxidative damage.
Article
Chemistry, Analytical
Chihong Ma, Qin Zhou, Jinjin Shi, Hua Gao, Di Huang, Huimin Xue, Han Wang, Zhenzhong Zhang, Sen Yang, Junli Zhang, Kaixiang Zhang
Summary: We developed a CRISPR-empowered electrochemical biosensor, named PER-E-CRISPR, for amplification-free and sensitive detection of miR-21. The biosensor combines the advantages of CRISPR/Cas13a and primer exchange reaction (PER) for target amplification. Under optimized conditions, the PER-E-CRISPR assay exhibits a linear range from 10-13 to 10-7 M and a limit of detection of 30.2 fM. The biosensor shows excellent performance in actual plasma, indicating promising prospects for miRNA detection in molecular diagnosis.
Article
Chemistry, Analytical
Gang Liang, Jie Zhao, Yufei Gao, Tao Xie, Jianhui Zhen, Ligang Pan, Wenwen Gong
Summary: Molecular docking (MD) analysis is widely used for studying the interaction between aptamers and small molecules. This study established steady-state aptamers of tertiary structures (SATS) using specific aptamers of tetracycline antibiotics as docking models. Molecular docking results revealed multiple binding sites in the SATS of aptamers, with significant variations in binding free energy (BFE) and docking score (DS). The study also proposed a method for MD analysis based on SATS, providing insights into binding mode and predicting binding sites.
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Analytical
Yu Su, Dandan Yang, Yanjie Wang, Jie Ding, Lan Ding, Daqian Song
Summary: In this study, a highly selective molecularly imprinted polymer Cu-MIPs@CS was designed and synthesized for bisphenol A (BPA). Cu-MIPs@CS showed significantly enhanced imprinting factor and selective factor towards BPA compared to MIPs@CS. It also exhibited superior discrimination ability between BPA and its structural analogue. Additionally, Cu-MIPs@CS were successfully applied as a solid phase extraction adsorbent for the determination of BPA in drinking water samples.
Article
Chemistry, Analytical
Yi Qiao, Qiongdan Zhang, Yukun He, Tianguang Cheng, Jing Tu
Summary: Single cell heterogeneity plays an important role in many biological phenomena, and distinguishing cells with specific mutations is beneficial for clinical diagnosis and drug screening. This study introduces a gel plate platform that can distinguish cell types based on their phenotypes, with low equipment requirement. The gel platform has potential in point-of-care circumstances and single-cell stimulation responses that prioritize efficiency and simplicity.
Article
Chemistry, Analytical
Chengke Wang, Shuyang Sun, Ping Wang, Huawei Zhao, Wenling Li
Summary: The food safety of aquatic products is a global concern. Nanotechnology-based analyses have advantages in the detection of bacteria, metal ions, and small molecule contaminants. This review summarizes the recent advances in biosensing strategies for aquatic products and highlights the application of nanomaterials, lateral flow-based biosensors, surface-enhanced Raman scattering, microfluidic chips, and molecular imprinting technologies.
Article
Chemistry, Analytical
Liping Zhu, Zeng Tang, Xuemei Zhang, Li Zhu, Tian Meng, Linying Yu, Ting Xiao, Shasha Lu, Xiaoli Xiong, Xiurong Yang
Summary: A sensitive off-on electrochemiluminescence DNA sensor was developed using Exo III-assisted cascade amplification system. The sensor achieved high selectivity and ultra-high sensitivity in detecting target DNA by utilizing ECL and SPR effects. This study provides a new perspective for designing highly sensitive and programmable ECL biosensors.
Article
Chemistry, Analytical
Tong Li, Mengxu Sun, Suping Xia, Ting Huang, Rong-Tian Li, Chunrong Li, Zong Dai, Jin-Xiang Chen, Jun Chen, Nuan Jia
Summary: Here, we developed a binary system based on DNA tetrahedron and fluorogenic RNA aptamers for highly specific and label-free mRNA imaging in living cells. This system achieved high specificity label-free detection of nucleic acids with a detection limit of 1.34 nM. The method has potential applications in early disease diagnosis and new drug development.
Article
Chemistry, Analytical
Yao Zhao, Shu Zhang, Wang Yao, Yuxuan Zhu, Jing Qian, Juan Yang, Nianjun Yang
Summary: A new hierarchical nanostructured composite with high conductivity and catalytic activity is synthesized. The sensor exhibits significant catalytic effect and high sensitivity for monitoring the environmental endocrine disruptor bisphenol A (BPA).