Article
Biotechnology & Applied Microbiology
Amr Fouda, Ahmed M. Eid, Mohamed Ali Abdel-Rahman, Ehab F. EL-Belely, Mohamed A. Awad, Saad El-Din Hassan, Zarraq E. AL-Faifi, Mohammed F. Hamza
Summary: In this study, metabolites secreted by brown algae were used as a biocatalyst for the green synthesis of magnesium oxide nanoparticles. The fabricated nanoparticles were characterized and tested for their antimicrobial and insecticidal activities, showing promising results.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Saad S. M. Hassan, Ehab M. Abdel Rahman, Gehan M. El-Subruiti, Ayman H. Kamel, Hanan M. Diab
Summary: This study describes the optimal conditions for removing uranium-238, thorium-232, and potassium-40 from wastewater using multiwalled carbon nanotubes (CNTs). The adsorption mechanism is mainly attributed to chemical interactions between the metal ions and surface functional groups of the CNTs. Various parameters such as pH, contact time, initial metal ion concentration, adsorbent dose, and temperature have been studied to understand their effect on the adsorption process. The results show that CNTs have a high efficiency in removing metal ions from wastewater under certain conditions.
Article
Psychology, Multidisciplinary
Zhenhuan Li, Dake Wang, Jaffar Abbas, Saad Hassan, Riaqa Mubeen
Summary: This study examines the impact of the COVID-19 pandemic on the travel and tourism industry, and addresses the role of technological innovation in crisis management and recovery. It proposes a research model to facilitate sustainable development and revival of international tourism activities.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Chemistry, Applied
Safaa S. S. Hassan, Demiana H. H. Hanna, Shymaa S. S. Medany
Summary: A Pd(II) complex was prepared from the interaction between a Schiff base derived from amoxicillin trihydrate and 4-N,N-dimethylaminobenzaldehyde. Nanoscale particles of the complex were observed using transmission electron microscopy and its chemical structure was confirmed through various techniques. The Pd(II) complex demonstrated the ability to inhibit human prostate cancer cells (PC3) by inhibiting cell growth in a dose-dependent manner. It also induced DNA damage and cell death through the mitochondria pathway.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Analytical
Saad S. M. Hassan, Ayman H. Kamel, Mahmoud Abdelwahab Fathy
Summary: A cost-effective, highly selective and sensitive paper-based potentiometric combined sensor has been developed for the monitoring of losartan potassium drug. The sensor exhibits excellent performance characteristics and remarkable selectivity towards related compounds. This sensor holds significant application potential in the pharmaceutical industry and hospitals.
Article
Chemistry, Physical
Ahmed M. Eid, Amr Fouda, Saad El-Din Hassan, Mohammed F. Hamza, Nada K. Alharbi, Amr Elkelish, Afaf Alharthi, Waheed M. Salem
Summary: The aqueous extract of Portulaca oleracea was utilized to bio-fabricate spherical and crystalline copper oxide nanoparticles (CuO-NPs). The synthesized CuO-NPs showed high stability and promising antimicrobial and catalytic activities. Additionally, they exhibited excellent decolorization and heavy metal removal capabilities in tanning wastewater treatment.
Article
Computer Science, Information Systems
Hassan Sani Abubakar, Zhiqin Zhao, Boning Wang, Saad Hassan Kiani, Naser Ojaroudi Parchin, Bandar Hakim
Summary: This work presents an eight-element antenna system operating at sub 6 GHz for a future MIMO system based on a modified E-slot on the ground. The modified E-slot effectively reduces coupling among the antenna components by suppressing the ground current effect. Experimental results demonstrate higher element isolation and desired bandwidth. The proposed antenna system shows potential for 5G mobile phone applications.
Article
Chemistry, Analytical
Saad S. M. Hassan, Mahmoud Abdelwahab Fathy, Ibrahim Moussa, M. Obaida, Ayman H. Kamel
Summary: A novel thin film of bismuth oxide (Bi2O3) was prepared on a fluorine doped tin oxide glass substrate (FTO) using a spray pyrolysis technique, and used as a pH sensing membrane. The film exhibited a porous structure, high roughness surface, and nano cracks. It showed excellent performance in monitoring a wide range of pH in aqueous solutions.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Engineering, Biomedical
Amr Fouda, Ebrahim Saied, Ahmed M. Eid, Fayza Kouadri, Ahmed M. Alemam, Mohammed F. Hamza, Maha Alharbi, Amr Elkelish, Saad El-Din Hassan
Summary: Zinc oxide nanoparticles were successfully synthesized using pomegranate peel extract as a green approach. The synthesized nanoparticles showed spherical, well-arranged structures with sizes ranging from 10-45 nm. These nanoparticles exhibited antimicrobial activity against pathogenic bacteria and unicellular fungi, as well as catalytic activity for the degradation of methylene blue dye.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Abeer Ashraf, Reem H. El-Gebaly, Ebtesam A. Mohamad
Summary: In this study, N-Acetylcysteine (NAC) was encapsulated into niosomes for the treatment of tumors in mice. The morphology and Fourier-transform infrared spectroscopy (FTIR) analysis of the NAC-encapsulated niosomes were measured. The results showed that the NAC-encapsulated niosomes had a spherical shape. Tissue histological studies emphasized the protective effect of the NAC-encapsulated niosomes against tumors. Overall, the oral delivery of NAC-encapsulated niosomes improved the antitumor effect.
EGYPTIAN JOURNAL OF CHEMISTRY
(2023)
Article
Computer Science, Information Systems
Saad Hassan Kiani, Huseyin Serif Savci, Hassan Sani Abubakar, Naser Ojaroudi Parchin, Hatem Rimli, Bandar Hakim
Summary: This article presents an eight-element tri-band MIMO antenna system for future handheld devices. The antenna resonates at three distinct 5G allocated bands and provides pattern and spatial diversity characteristics. The measurements of the fabricated MIMO system are in good agreement with the simulations, and the system meets the required standards for envelope correlation coefficient and mean effective gain ratio. The Channel Capacity of the system is approximately 3 times that of 2 x 2 MIMO operations.
Article
Materials Science, Multidisciplinary
Amr Fouda, Mahmoud Abdel-Nasser, Ahmed Mohamed Aly Khalil, Saad El-Din Hassan, Gomaa Abdel-Maksoud
Summary: In this study, the deterioration aspects of a historical manuscript from the 17th century were evaluated, with a focus on the role of associated fungal communities. The results showed that the manuscript exhibited signs of dust, dirt, erosion, stains, bores, weakness, missed parts, decreasing paper crystallinity, shifting wavenumbers of cellulosic band, and changing color and pH. Thirteen fungal strains were identified as being associated with the manuscript, and these strains were found to secrete various hydrolytic enzymes that play a critical role in biodeterioration.
NPJ MATERIALS DEGRADATION
(2022)
Article
Chemistry, Multidisciplinary
Saad Hassan Kiani, Mohamed Marey, Huseyin Serif Savci, Hala Mostafa, Umair Rafique, Muhammad Amir Khan
Summary: This work presents a cost-effective MIMO antenna system for next-generation smartphones, which is developed on a thin substrate with good impedance bandwidth and isolation. The system offers pattern and spatial diversity characteristics and holds promising features for future smartphones.
APPLIED SCIENCES-BASEL
(2022)
Article
Chemistry, Multidisciplinary
Amr Fouda, Saad El-Din Hassan, Ahmed M. Eid, Mohamed A. Awad, Khalid Althumayri, Naglaa Fathi Badr, Mohammed F. Hamza
Summary: The biomass filtrate of endophytic bacterial strain, Brevibacillus brevis PI-5, was used as a biocatalyst to reduce and stabilize copper oxide nanoparticles (CuO-NPs). The synthesized CuO-NPs exhibited high activity in antifungal, anticancer, and larvicidal activities.
GREEN PROCESSING AND SYNTHESIS
(2022)
Proceedings Paper
Computer Science, Artificial Intelligence
Akhter Al Amin, Saad Hassan, Cecilia O. Alm, Matt Huenerfauth
Summary: This study found that normalized contextualized word embeddings generated using BERT correlated better with manually annotated importance scores than word2vec-based word embeddings. It suggests the need to construct caption evaluation metrics that take the relative importance of words in a transcript into account. By training word importance models, the researchers achieved an F1-score of 0.57 in the 6-class word importance classification task.
PROCEEDINGS OF THE SECOND WORKSHOP ON LANGUAGE TECHNOLOGY FOR EQUALITY, DIVERSITY AND INCLUSION (LTEDI 2022)
(2022)
Article
Chemistry, Analytical
Qian Wu, Li Tian, Xiangyu Shan, Huiling Li, Chao Li, Juan Lu
Summary: A novel ECL sensor was developed by modifying Fe3CuO4-Ru(bpy)3+ and GO-CdS@ZnS on the electrode for the detection of permethrin. The sensor exhibited high sensitivity and a wide detection range.
Article
Chemistry, Analytical
Tingting Gong, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescent biosensing system for high sensitivity detection of MT was established using a new Ag+-stabilized DNA triplex probe (Ag+-SDTP) combined with catalytic hairpin assembly (CHA) and CRISPR/Cas12a signal enhancements. The sensing method is able to selectively detect MT from other non-specific molecules and can achieve low level detection of MT in diluted human serums, demonstrating its potential for monitoring disease-specific MT biomarker at trace levels.
Article
Chemistry, Analytical
Estrella Sanz Rodriguez, Kyra Wood, Paul R. Haddad, Brett Paull
Summary: This study presents a simple, rapid, and reliable method for determining boron in aqueous solutions using suppressed ion chromatography coupled to electrospray ionisation-triple quadrupole mass spectrometry. The method achieved a low limit of detection and demonstrated excellent analytical performance.
Article
Chemistry, Analytical
Aline Cournut, Paul Moustiez, Yannick Coffinier, Christine Enjalbal, Claudia Bich
Summary: Alzheimer's disease is a major cause of senile dementia and is characterized by the aggregation of neurofibrillary tangles and amyloid plaques in the brain. The A beta 1-42 peptide is considered the primary cause of neurotoxicity due to its insolubility and subsequent aggregation. A beta 1-42 and A beta 1-40 have been identified as relevant biomarkers for AD diagnosis, and SurfaceAssisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) was used to monitor the A beta 1-42/A beta 1-40 ratio without prior sample treatment.
Article
Chemistry, Analytical
Dotse Selali Chormey, Buse Tugba Zaman, Tulay Borahan Kustanto, Sezin Erarpat Bodur, Suleyman Bodur, Elif Ozturk Er, Sezgin Bakirdere
Summary: This review provides an overview of the harmful effects of endocrine disrupting chemicals (EDCs) on human health and introduces the methods for analyzing EDCs. Recent research has focused on using green chemicals, such as deep eutectic solvents (DESs), for microextraction to ensure environmental safety.
Article
Chemistry, Analytical
Yan Zhang, Renfeng Xu, Jingjing Wu, Zhenghong Zhang, Yuhuang Wang, Hongqin Yang, Sheng Zhang
Summary: This study visualized the pore-like structures in prostate cancer cell membranes after treatment with the anticancer drug paclitaxel, demonstrating its mechanism of action related to oxidative damage.
Article
Chemistry, Analytical
Chihong Ma, Qin Zhou, Jinjin Shi, Hua Gao, Di Huang, Huimin Xue, Han Wang, Zhenzhong Zhang, Sen Yang, Junli Zhang, Kaixiang Zhang
Summary: We developed a CRISPR-empowered electrochemical biosensor, named PER-E-CRISPR, for amplification-free and sensitive detection of miR-21. The biosensor combines the advantages of CRISPR/Cas13a and primer exchange reaction (PER) for target amplification. Under optimized conditions, the PER-E-CRISPR assay exhibits a linear range from 10-13 to 10-7 M and a limit of detection of 30.2 fM. The biosensor shows excellent performance in actual plasma, indicating promising prospects for miRNA detection in molecular diagnosis.
Article
Chemistry, Analytical
Gang Liang, Jie Zhao, Yufei Gao, Tao Xie, Jianhui Zhen, Ligang Pan, Wenwen Gong
Summary: Molecular docking (MD) analysis is widely used for studying the interaction between aptamers and small molecules. This study established steady-state aptamers of tertiary structures (SATS) using specific aptamers of tetracycline antibiotics as docking models. Molecular docking results revealed multiple binding sites in the SATS of aptamers, with significant variations in binding free energy (BFE) and docking score (DS). The study also proposed a method for MD analysis based on SATS, providing insights into binding mode and predicting binding sites.
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Analytical
Yu Su, Dandan Yang, Yanjie Wang, Jie Ding, Lan Ding, Daqian Song
Summary: In this study, a highly selective molecularly imprinted polymer Cu-MIPs@CS was designed and synthesized for bisphenol A (BPA). Cu-MIPs@CS showed significantly enhanced imprinting factor and selective factor towards BPA compared to MIPs@CS. It also exhibited superior discrimination ability between BPA and its structural analogue. Additionally, Cu-MIPs@CS were successfully applied as a solid phase extraction adsorbent for the determination of BPA in drinking water samples.
Article
Chemistry, Analytical
Yi Qiao, Qiongdan Zhang, Yukun He, Tianguang Cheng, Jing Tu
Summary: Single cell heterogeneity plays an important role in many biological phenomena, and distinguishing cells with specific mutations is beneficial for clinical diagnosis and drug screening. This study introduces a gel plate platform that can distinguish cell types based on their phenotypes, with low equipment requirement. The gel platform has potential in point-of-care circumstances and single-cell stimulation responses that prioritize efficiency and simplicity.
Article
Chemistry, Analytical
Chengke Wang, Shuyang Sun, Ping Wang, Huawei Zhao, Wenling Li
Summary: The food safety of aquatic products is a global concern. Nanotechnology-based analyses have advantages in the detection of bacteria, metal ions, and small molecule contaminants. This review summarizes the recent advances in biosensing strategies for aquatic products and highlights the application of nanomaterials, lateral flow-based biosensors, surface-enhanced Raman scattering, microfluidic chips, and molecular imprinting technologies.
Article
Chemistry, Analytical
Liping Zhu, Zeng Tang, Xuemei Zhang, Li Zhu, Tian Meng, Linying Yu, Ting Xiao, Shasha Lu, Xiaoli Xiong, Xiurong Yang
Summary: A sensitive off-on electrochemiluminescence DNA sensor was developed using Exo III-assisted cascade amplification system. The sensor achieved high selectivity and ultra-high sensitivity in detecting target DNA by utilizing ECL and SPR effects. This study provides a new perspective for designing highly sensitive and programmable ECL biosensors.
Article
Chemistry, Analytical
Tong Li, Mengxu Sun, Suping Xia, Ting Huang, Rong-Tian Li, Chunrong Li, Zong Dai, Jin-Xiang Chen, Jun Chen, Nuan Jia
Summary: Here, we developed a binary system based on DNA tetrahedron and fluorogenic RNA aptamers for highly specific and label-free mRNA imaging in living cells. This system achieved high specificity label-free detection of nucleic acids with a detection limit of 1.34 nM. The method has potential applications in early disease diagnosis and new drug development.
Article
Chemistry, Analytical
Yao Zhao, Shu Zhang, Wang Yao, Yuxuan Zhu, Jing Qian, Juan Yang, Nianjun Yang
Summary: A new hierarchical nanostructured composite with high conductivity and catalytic activity is synthesized. The sensor exhibits significant catalytic effect and high sensitivity for monitoring the environmental endocrine disruptor bisphenol A (BPA).