Article
Spectroscopy
Arul Pundi, Chi-Jung Chang, Jemkun Chen, Shih-Rong Hsieh, Ming-Ching Lee
Summary: The development of fluorescence molecules for the detection of L-tryptophan has attracted attention, and a chiral sensor SDPA was synthesized. It showed fluorescence quenching by Fe3+ and Cu2+ and could detect L-tryptophan and L-cysteine at trace levels by turn-on fluorescence.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Multidisciplinary
Snehasish Debnath, Ratish R. Nair, Riya Ghosh, Gaddam Kiranmai, Narsini Radhakishan, Narayana Nagesh, Pabitra B. Chatterjee
Summary: A series of copper(II) compounds were synthesized and developed as fluorogenic probes for measuring the cardiac marker homocysteine (Hcy). These probes showed high specificity and sensitivity for Hcy, making them suitable for clinical testing.
CHEMICAL COMMUNICATIONS
(2022)
Article
Nanoscience & Nanotechnology
Kexin Wang, Jiaxuan Liu, Mohamed E. El-Khouly, Xiaosheng Cui, Qiang Che, Bin Zhang, Yu Chen
Summary: The development of transient electronic devices is crucial for protecting sensitive information stored in electronic memory devices. A flexible electronic device with a highly water-soluble active material has been successfully fabricated, showing rewritable resistive random access memory effect and history-dependent memristive switching performance. This device emulates the learning and memorizing functions of biological systems and can be rapidly destroyed by adding water.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Kexin Wang, Jiaxuan Liu, Mohamed E. El-Khouly, Xiaosheng Cui, Qiang Che, Bin Zhang, Yu Chen
Summary: The key to protecting sensitive information stored in electronic memory devices is to develop transient electronic devices that can be quickly destroyed in an emergency. Researchers have successfully fabricated a flexible electronic device capable of protecting sensitive information by using a highly water-soluble active material. This device can emulate the learning and memorizing functions of biological systems and can be rapidly destroyed when water is added.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Physical
Subash Vetri Selvi, Varghese Lincy, Shen-Ming Chen, Po-Da Hong, Adhimoorthy Prasannan
Summary: A water-soluble Sr-NiO@P3ThA nanocomposite material was synthesized and utilized as an effective electrode for detecting water-soluble catechol contaminations. The modified electrode exhibited good selectivity and sensitivity, successfully detecting catechol in river water and tap water. An eco-friendly, water-soluble, simple, sensitive, and selective approach for determining catechol contaminations in water resources was established.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Applied
Mikas Sadauskas, Martynas Jakutis, Vytautas Petkevicius, Martynas Malikenas, Viktorija Preitakaite, Justas Vaitekunas, Rolandas Meskys
Summary: This article presents a method for synthesizing asymmetric carboxy-substituted indirubins. It uses indole-5-carboxylic acid or indole-6-carboxylic acid and 2-indolinone derivatives as substrates for bacterial monooxygenase-driven enzymatic bioconversion in different bacterial hosts. The bioconversion system achieved a high titer of monocarboxyindirubin production, with up to 327 mg/L for 5-bromoindirubin-6-carboxylic acid during a 16-hour incubation period. The synthesized monocarboxyindirubins have high water solubility and potential antiproliferative activity, making them promising candidates.
Article
Chemistry, Analytical
Fengxia Su, Xiaofei He, Pengbo Zhang, Hui Wang, Zhengping Li
Summary: The COVID-19 epidemic caused by the SARS-CoV-2 virus has had a significant negative impact on society and global health. A sensitive, quick, and reasonably priced SARS-CoV-2 detection technology is urgently needed. Reverse transcription-loop-mediated isothermal amplification (RT-LAMP) is a promising method that amplifies a small amount of RNA to a detectable level at isothermal condition without the need for expensive equipment. In this study, a water-soluble polythiophene-based colorimetric method combined with RT-LAMP was established for fast and sensitive detection of SARS-CoV-2 RNA.
Article
Food Science & Technology
Akira Kurniawan Ishii, Criselda Toto Pacioles, Lilian Were
Summary: In the process of alkaline sunflower protein extraction, de-phenolization can be carried out to prevent greening. Thiol-containing dough conditioners, such as L-cysteine hydrochloride and glutathione, were investigated as an alternative de-greening strategy. However, the addition of cysteine or glutathione resulted in different effects on browning and protein unfolding.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Chemistry, Applied
Alagumalai Krishnapandi, Subash Vetri Selvi, Adhimoorthi Prasannan, Po-Da Hong, Seong-Cheol Kim, Sangaraju Sambasivam
Summary: This study explores the performance of a water-soluble poly-thiophene carboxylic acid-modified glassy carbon electrode (PTPh3C/GCE) for detecting acebutolol (ACE) in various water sources. The sensor exhibited a wide linear range, low detection limit, good sensitivity, and high selectivity. It was successfully used to detect ACE in environmental water samples with satisfactory recoveries.
REACTIVE & FUNCTIONAL POLYMERS
(2023)
Article
Spectroscopy
A. Yu Belik, A. Yu Rybkin, N. S. Goryachev, A. P. Sadkov, N. Filatova, A. G. Buyanovskaya, V. N. Talanova, Z. S. Klemenkova, V. S. Romanova, M. O. Koifman, A. A. Terentiev, A. Kotelnikov
Summary: The study focused on the synthesis and photodynamic activity of water-soluble amino acid fullerene C-60 derivatives (AFD) and their covalent addition of dye pyropheophorbide (PPa) in aqueous solution. The dyads formed nanoassociates through self-assembly, exhibiting a switch in photodynamic mechanism from type II to I and significant phototoxicity in Hela cells, suggesting potential against hypoxic tumors.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Review
Materials Science, Multidisciplinary
Hanaa H. AL-Refai, Aisha A. Ganash, Mahmoud A. Hussein
Summary: Conducting polymer nanocomposites combine the advantages of conducting polymers and organic/inorganic nanoparticles, making them useful for a variety of applications. This review focuses on the fundamental synthesis methods for nanocomposite material-based polythiophene and its derivatives, highlighting their enhanced electrochemical sensor performance compared to sensors without nanocomponents. Analytical performance of modified electrodes for different targets is summarized and compared over the past 5 years.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Jia Fu, Hongqing Wang, Chaoxuan Dong, Chuchu Xi, Jun Xie, Shengtian Lai, Ruoyun Chen, Jie Kang
Summary: The study identified fifteen new water-soluble alkaloids from Portulaca oleracea L., which exhibited promising anti-inflammatory properties by reducing interleukin-6 and nitric oxide levels induced by lipopolysaccharide in macrophages. The structures and stereoconfigurations of these alkaloids were determined through spectroscopic analysis, ECD data, and X-ray diffraction.
BIOORGANIC CHEMISTRY
(2021)
Article
Materials Science, Multidisciplinary
Jincheng Zhang, Huatian Duan, Ying Hong, Jingyu Deng, Li-Juan Fan
Summary: A series of cationic conjugated polymers were synthesized for the detection of ATP, and the fluorescence of the polymers was quenched upon adding ATP. The sensitivity of the polymer to ATP increased with the density of the quaternary ammonium group. The study provides a general strategy for designing sensing systems for biomolecules with complex structures.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Chemistry, Physical
Karolina Zalewska, Malgorzata E. Zakrzewska, Luis C. Branco
Summary: Ionic liquids' structures and properties can be tailored by changing cation/anion combinations or grafting enantiopure moieties, creating bioinspired chiral molecules for various applications. Chiral ionic liquids (CILs) based on biomolecules like amino acids have been synthesized and tested, showing promising results in asymmetric aldol condensation reactions with high yields and enantioselectivity.
Article
Spectroscopy
Xufeng Hou, Zhensheng Li, Yunqiang Li, Qihang Zhou, Chunhui Liu, Dang Fan, Jinjin Wang, Ruijie Xu, Zhihong Xu
Summary: A novel near-infrared optical and fluorescent probe (NTC) was designed for sensing cysteine with high selectivity and sensitivity. Upon reaction with cysteine, the probe exhibited about 40-fold fluorescence enhancement due to the recovery of intramolecular charge transfer.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Chemistry, Analytical
Qian Wu, Li Tian, Xiangyu Shan, Huiling Li, Chao Li, Juan Lu
Summary: A novel ECL sensor was developed by modifying Fe3CuO4-Ru(bpy)3+ and GO-CdS@ZnS on the electrode for the detection of permethrin. The sensor exhibited high sensitivity and a wide detection range.
Article
Chemistry, Analytical
Tingting Gong, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescent biosensing system for high sensitivity detection of MT was established using a new Ag+-stabilized DNA triplex probe (Ag+-SDTP) combined with catalytic hairpin assembly (CHA) and CRISPR/Cas12a signal enhancements. The sensing method is able to selectively detect MT from other non-specific molecules and can achieve low level detection of MT in diluted human serums, demonstrating its potential for monitoring disease-specific MT biomarker at trace levels.
Article
Chemistry, Analytical
Estrella Sanz Rodriguez, Kyra Wood, Paul R. Haddad, Brett Paull
Summary: This study presents a simple, rapid, and reliable method for determining boron in aqueous solutions using suppressed ion chromatography coupled to electrospray ionisation-triple quadrupole mass spectrometry. The method achieved a low limit of detection and demonstrated excellent analytical performance.
Article
Chemistry, Analytical
Aline Cournut, Paul Moustiez, Yannick Coffinier, Christine Enjalbal, Claudia Bich
Summary: Alzheimer's disease is a major cause of senile dementia and is characterized by the aggregation of neurofibrillary tangles and amyloid plaques in the brain. The A beta 1-42 peptide is considered the primary cause of neurotoxicity due to its insolubility and subsequent aggregation. A beta 1-42 and A beta 1-40 have been identified as relevant biomarkers for AD diagnosis, and SurfaceAssisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) was used to monitor the A beta 1-42/A beta 1-40 ratio without prior sample treatment.
Article
Chemistry, Analytical
Dotse Selali Chormey, Buse Tugba Zaman, Tulay Borahan Kustanto, Sezin Erarpat Bodur, Suleyman Bodur, Elif Ozturk Er, Sezgin Bakirdere
Summary: This review provides an overview of the harmful effects of endocrine disrupting chemicals (EDCs) on human health and introduces the methods for analyzing EDCs. Recent research has focused on using green chemicals, such as deep eutectic solvents (DESs), for microextraction to ensure environmental safety.
Article
Chemistry, Analytical
Yan Zhang, Renfeng Xu, Jingjing Wu, Zhenghong Zhang, Yuhuang Wang, Hongqin Yang, Sheng Zhang
Summary: This study visualized the pore-like structures in prostate cancer cell membranes after treatment with the anticancer drug paclitaxel, demonstrating its mechanism of action related to oxidative damage.
Article
Chemistry, Analytical
Chihong Ma, Qin Zhou, Jinjin Shi, Hua Gao, Di Huang, Huimin Xue, Han Wang, Zhenzhong Zhang, Sen Yang, Junli Zhang, Kaixiang Zhang
Summary: We developed a CRISPR-empowered electrochemical biosensor, named PER-E-CRISPR, for amplification-free and sensitive detection of miR-21. The biosensor combines the advantages of CRISPR/Cas13a and primer exchange reaction (PER) for target amplification. Under optimized conditions, the PER-E-CRISPR assay exhibits a linear range from 10-13 to 10-7 M and a limit of detection of 30.2 fM. The biosensor shows excellent performance in actual plasma, indicating promising prospects for miRNA detection in molecular diagnosis.
Article
Chemistry, Analytical
Gang Liang, Jie Zhao, Yufei Gao, Tao Xie, Jianhui Zhen, Ligang Pan, Wenwen Gong
Summary: Molecular docking (MD) analysis is widely used for studying the interaction between aptamers and small molecules. This study established steady-state aptamers of tertiary structures (SATS) using specific aptamers of tetracycline antibiotics as docking models. Molecular docking results revealed multiple binding sites in the SATS of aptamers, with significant variations in binding free energy (BFE) and docking score (DS). The study also proposed a method for MD analysis based on SATS, providing insights into binding mode and predicting binding sites.
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Analytical
Yu Su, Dandan Yang, Yanjie Wang, Jie Ding, Lan Ding, Daqian Song
Summary: In this study, a highly selective molecularly imprinted polymer Cu-MIPs@CS was designed and synthesized for bisphenol A (BPA). Cu-MIPs@CS showed significantly enhanced imprinting factor and selective factor towards BPA compared to MIPs@CS. It also exhibited superior discrimination ability between BPA and its structural analogue. Additionally, Cu-MIPs@CS were successfully applied as a solid phase extraction adsorbent for the determination of BPA in drinking water samples.
Article
Chemistry, Analytical
Yi Qiao, Qiongdan Zhang, Yukun He, Tianguang Cheng, Jing Tu
Summary: Single cell heterogeneity plays an important role in many biological phenomena, and distinguishing cells with specific mutations is beneficial for clinical diagnosis and drug screening. This study introduces a gel plate platform that can distinguish cell types based on their phenotypes, with low equipment requirement. The gel platform has potential in point-of-care circumstances and single-cell stimulation responses that prioritize efficiency and simplicity.
Article
Chemistry, Analytical
Chengke Wang, Shuyang Sun, Ping Wang, Huawei Zhao, Wenling Li
Summary: The food safety of aquatic products is a global concern. Nanotechnology-based analyses have advantages in the detection of bacteria, metal ions, and small molecule contaminants. This review summarizes the recent advances in biosensing strategies for aquatic products and highlights the application of nanomaterials, lateral flow-based biosensors, surface-enhanced Raman scattering, microfluidic chips, and molecular imprinting technologies.
Article
Chemistry, Analytical
Liping Zhu, Zeng Tang, Xuemei Zhang, Li Zhu, Tian Meng, Linying Yu, Ting Xiao, Shasha Lu, Xiaoli Xiong, Xiurong Yang
Summary: A sensitive off-on electrochemiluminescence DNA sensor was developed using Exo III-assisted cascade amplification system. The sensor achieved high selectivity and ultra-high sensitivity in detecting target DNA by utilizing ECL and SPR effects. This study provides a new perspective for designing highly sensitive and programmable ECL biosensors.
Article
Chemistry, Analytical
Tong Li, Mengxu Sun, Suping Xia, Ting Huang, Rong-Tian Li, Chunrong Li, Zong Dai, Jin-Xiang Chen, Jun Chen, Nuan Jia
Summary: Here, we developed a binary system based on DNA tetrahedron and fluorogenic RNA aptamers for highly specific and label-free mRNA imaging in living cells. This system achieved high specificity label-free detection of nucleic acids with a detection limit of 1.34 nM. The method has potential applications in early disease diagnosis and new drug development.
Article
Chemistry, Analytical
Yao Zhao, Shu Zhang, Wang Yao, Yuxuan Zhu, Jing Qian, Juan Yang, Nianjun Yang
Summary: A new hierarchical nanostructured composite with high conductivity and catalytic activity is synthesized. The sensor exhibits significant catalytic effect and high sensitivity for monitoring the environmental endocrine disruptor bisphenol A (BPA).