Article
Biochemistry & Molecular Biology
Alicia Moreno-Ortega, Gema Pereira-Caro, Iziar A. Ludwig, Maria-Jose Motilva, Jose Manuel Moreno-Rojas
Summary: By using UHPLC-HRMS, this study identified and quantified 33 OSCs excreted in urine 24 h after the consumption of 20 g of black garlic. The main OSCs were methiin, isoalliin, S-(2-carboxypropyl)-L-cysteine, and S-propyl-L-cysteine. Metabolites such as NASAC, NASACS, and NACPC derived from SAC, alliin, and S-(2-carboxypropyl)-L-cysteine were also detected. The total excretion of OSCs after the ingestion of black garlic was 64,312 +/- 26,584 nmol.
Article
Plant Sciences
Xuqin Yang, Yiren Su, Jiaying Wu, Wen Wan, Huijian Chen, Xiaoying Cao, Junjuan Wang, Zhong Zhang, Youzhi Wang, Deliang Ma, G. J. Loake, Jihong Jiang
Summary: This study revealed differential alliin content in different parts of garlic, with a decrease in alliin levels in mature leaves following injury. Furthermore, genes related to cysteine and serine biosynthetic pathways were up-regulated in mature garlic leaves, potentially contributing to alliin accumulation.
Article
Food Science & Technology
Chunfeng Liu, Liandeng Lu, Chuanjia Yang, Chengtuo Niu, Jinjing Wang, Feiyun Zheng, Qi Li
Summary: The thermal stabilities of alliin, S-allyl-L-cysteine (S-ALC), and gamma-glutamyl-cysteine (gamma-GC) were investigated during black garlic processing. It was found that gamma-GC was more stable than alliin and S-ALC. Alliin and its related sulfides changed significantly during the Maillard reaction stage. Further research showed that the optimal conditions for increasing the total content of alliin, S-ALC, and gamma-GC in black garlic were 90% humidity, 80 degrees C temperature, and 210 hours processing time. Sensory analysis indicated that the optimized black garlic samples scored higher in various aspects.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Raffaella Scanga, Mariafrancesca Scalise, Filomena Rovella, Teresa Maria Rosaria Regina, Michele Galluccio, Cesare Indiveri
Summary: LAT1 is a key player in cell homeostasis, forming a complex with CD98 to provide essential amino acids and hormones. Altered expression of LAT1 is linked to human diseases such as cancer and diabetes. The recent resolution of the LAT1-CD98 3D structure has opened up new possibilities for studying its interaction with different molecules and identifying potential drugs or natural substrates for therapeutic or supplement purposes.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Food Science & Technology
Yayi Jiang, Rensong Yue, Guojie Liu, Jun Liu, Bo Peng, Maoyi Yang, Lianxue Zhao, Zihan Li
Summary: Garlic, a medicinal plant and functional food, has shown positive effects in the treatment of diabetes and its complications. This article provides a clear and comprehensive summary of the research from the past ten years, focusing on the mechanisms and development processes of garlic in the treatment of diabetes, aiming to provide a new perspective for the treatment of diabetes and promote the efficient development of this field.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Food Science & Technology
Min-Jung Kang, Jae-Ran Kang, Min Seok Woo, Dawon Kang, Jung-Hye Shin
Summary: This study examined the effect of long-term storage on the quality of black garlic (BG) produced from raw garlic. The results showed that stored raw garlic (SRG) had lower S-allylcysteine (SAC) content and lower antioxidant activity compared to non-stored raw garlic (NSRG) in BG production. Therefore, it is important to establish an aging method suitable for stored raw garlic to achieve high SAC content in BG production.
Review
Food Science & Technology
Jieying Li, Younas Dadmohammadi, Alireza Abbaspourrad
Summary: There is a significant demand in the food industry for natural flavors, but many flavor molecules are unstable outside their original sources. Understanding the link between food processing conditions and flavor generation is crucial for stability. Garlic and chili flavors can be generated through thermal processing, with capsaicinoids being reported as a thermally stable chili pepper flavor.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Materials Science, Multidisciplinary
Pengshuo Fan, Yizhou Hao, Cong Xu, Yangfei Cao, Xianwu Huang, Jiahui Huang, Xuanyu Lyu, Run Zhu, Di Lei, Wei Li, Dong Yang, Haiwei Liang, Jianhao Chen, Tongtao Li, Angang Dong
Summary: The use of 3D porous wrinkled graphitic carbon (PWGC) as the carbon support in proton-exchange membrane fuel cells improves their durability and stability. The PWGC, synthesized using a catalyst-free, plasma-enhanced chemical vapor deposition approach, possesses a high surface area, a high degree of graphitization, and exceptional corrosion resistance. Pt/PWGC catalysts demonstrate superior high potential stability compared to those made with commercial carbon supports, and Pt@C/PWGC catalysts show significantly improved durability with the introduction of a sacrificial layer strategy.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Biochemistry & Molecular Biology
Ilya S. Voronov, Danil I. Falev, Anna V. Faleva, Nikolay V. Ul'yanovskii, Dmitry S. Kosyakov
Summary: In this study, a rapid, sensitive, and low-cost method for the simultaneous quantification of ten pentacyclic triterpenoids (PCTs) was proposed. High-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) was used with porous graphitic carbon (Hypercarb) as a stationary phase capable of specific interactions with analytes. The method successfully separated all target analytes within 8 minutes and achieved limits of detection in the range of 4-10(4) mu g/L. It was validated and applied to the determination of PCTs in various plant samples.
Article
Chemistry, Multidisciplinary
Lei Huang, Ya-Qiong Su, Ruijuan Qi, Dai Dang, Yanyang Qin, Shibo Xi, Shahid Zaman, Bo You, Shujiang Ding, Bao Yu Xia
Summary: Integrated fabrication of porous Pt-rich alloy encapsulated by graphitic carbon via integration engineering exhibits optimized reaction pathway and improved oxygen reduction reaction performance. The hybrid catalyst outperforms commercial Pt/C catalyst in full-cell assessment, attributed to the mutual assistance between porous Pt alloy and Co-N-C.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Environmental Sciences
Zhengtai Zha, Zhi Zhang, Ping Xiang, Hongyi Zhu, Xueping Shi, Shihao Chen
Summary: In this study, nitrogen self-doped porous graphitic carbon was successfully synthesized using mangosteen peel as a carbon and nitrogen source, combined with molten KOH activation and Co2+ catalytic graphitization. The resulting catalyst, MPC-800, showed good oxygen reduction reaction activity and slightly outperformed commercial Pt/C cathode in microbial fuel cells. This work offers a novel method for synthesizing an efficient oxygen reduction reaction catalyst for microbial fuel cells using low-cost and widely available waste mangosteen peel.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Engineering, Environmental
Chitiphon Chuaicham, Karthikeyan Sekar, Yihuang Xiong, Vellaichamy Balakumar, Yanisa Mittraphab, Kuniyoshi Shimizu, Bunsho Ohtani, Ismaila Dabo, Keiko Sasaki
Summary: In this study, a series of oxygen-doped hollow porous surface graphitic carbon nitride samples were prepared by one-pot thermal polycondensation, showing superior photocatalytic performance for the degradation of organic pollutants in wastewater containing pharmaceutical waste. The improved light absorption, reduced recombination rate of photogenerated electron and hole, and enhanced electron transportation of the OCN samples contributed to their excellent degradation performance.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Materials Science, Multidisciplinary
Xinxin Zou, Yanling Yang, Huajun Chen, Xiao-Lei Shi, Shaoli Song, Zhi-Gang Chen
Summary: Constructing a hierarchical meso/macro-porous structure for TiO2/g-C3N4 nanofibers improves light absorption, carrier separation efficiency, and photocatalytic performance, leading to a higher H-2 evolution rate. This work presents a new strategy for enhancing hydrogen production and provides an ideal solution for TiO2/g-C3N4 photocatalysts.
MATERIALS & DESIGN
(2021)
Article
Acoustics
Xiaoxu Xuan, Mengjie Wang, Weibin You, Sivakumar Manickam, Yang Tao, Joon Yong Yoon, Xun Sun
Summary: Hydrodynamic cavitation was used for the first time to intensify the alkali activation of graphene-based materials, resulting in the formation of new materials with high surface area and good cycle performance. These materials exhibited increased capacitance and long-term stability, making them promising choices for energy storage technologies.
ULTRASONICS SONOCHEMISTRY
(2023)
Article
Chemistry, Physical
Lang He, Wenyuan Zhang, Sheng Liu, Yan Zhao
Summary: The CoO@N-GC-500 catalyst, prepared by a facile polymer thermal treatment method, exhibits excellent photocatalytic performance for the reduction of CO2 in water, with high yields of CH4 and CO under visible light irradiation. This is attributed to efficient separation of photogenerated electron-hole pairs, large specific surface area, and strong visible light absorption capacity, paving the way for practical applications of CoO catalysts in artificial photosynthesis.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2021)
Article
Chemistry, Analytical
Qian Wu, Li Tian, Xiangyu Shan, Huiling Li, Chao Li, Juan Lu
Summary: A novel ECL sensor was developed by modifying Fe3CuO4-Ru(bpy)3+ and GO-CdS@ZnS on the electrode for the detection of permethrin. The sensor exhibited high sensitivity and a wide detection range.
Article
Chemistry, Analytical
Tingting Gong, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescent biosensing system for high sensitivity detection of MT was established using a new Ag+-stabilized DNA triplex probe (Ag+-SDTP) combined with catalytic hairpin assembly (CHA) and CRISPR/Cas12a signal enhancements. The sensing method is able to selectively detect MT from other non-specific molecules and can achieve low level detection of MT in diluted human serums, demonstrating its potential for monitoring disease-specific MT biomarker at trace levels.
Article
Chemistry, Analytical
Estrella Sanz Rodriguez, Kyra Wood, Paul R. Haddad, Brett Paull
Summary: This study presents a simple, rapid, and reliable method for determining boron in aqueous solutions using suppressed ion chromatography coupled to electrospray ionisation-triple quadrupole mass spectrometry. The method achieved a low limit of detection and demonstrated excellent analytical performance.
Article
Chemistry, Analytical
Aline Cournut, Paul Moustiez, Yannick Coffinier, Christine Enjalbal, Claudia Bich
Summary: Alzheimer's disease is a major cause of senile dementia and is characterized by the aggregation of neurofibrillary tangles and amyloid plaques in the brain. The A beta 1-42 peptide is considered the primary cause of neurotoxicity due to its insolubility and subsequent aggregation. A beta 1-42 and A beta 1-40 have been identified as relevant biomarkers for AD diagnosis, and SurfaceAssisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) was used to monitor the A beta 1-42/A beta 1-40 ratio without prior sample treatment.
Article
Chemistry, Analytical
Dotse Selali Chormey, Buse Tugba Zaman, Tulay Borahan Kustanto, Sezin Erarpat Bodur, Suleyman Bodur, Elif Ozturk Er, Sezgin Bakirdere
Summary: This review provides an overview of the harmful effects of endocrine disrupting chemicals (EDCs) on human health and introduces the methods for analyzing EDCs. Recent research has focused on using green chemicals, such as deep eutectic solvents (DESs), for microextraction to ensure environmental safety.
Article
Chemistry, Analytical
Yan Zhang, Renfeng Xu, Jingjing Wu, Zhenghong Zhang, Yuhuang Wang, Hongqin Yang, Sheng Zhang
Summary: This study visualized the pore-like structures in prostate cancer cell membranes after treatment with the anticancer drug paclitaxel, demonstrating its mechanism of action related to oxidative damage.
Article
Chemistry, Analytical
Chihong Ma, Qin Zhou, Jinjin Shi, Hua Gao, Di Huang, Huimin Xue, Han Wang, Zhenzhong Zhang, Sen Yang, Junli Zhang, Kaixiang Zhang
Summary: We developed a CRISPR-empowered electrochemical biosensor, named PER-E-CRISPR, for amplification-free and sensitive detection of miR-21. The biosensor combines the advantages of CRISPR/Cas13a and primer exchange reaction (PER) for target amplification. Under optimized conditions, the PER-E-CRISPR assay exhibits a linear range from 10-13 to 10-7 M and a limit of detection of 30.2 fM. The biosensor shows excellent performance in actual plasma, indicating promising prospects for miRNA detection in molecular diagnosis.
Article
Chemistry, Analytical
Gang Liang, Jie Zhao, Yufei Gao, Tao Xie, Jianhui Zhen, Ligang Pan, Wenwen Gong
Summary: Molecular docking (MD) analysis is widely used for studying the interaction between aptamers and small molecules. This study established steady-state aptamers of tertiary structures (SATS) using specific aptamers of tetracycline antibiotics as docking models. Molecular docking results revealed multiple binding sites in the SATS of aptamers, with significant variations in binding free energy (BFE) and docking score (DS). The study also proposed a method for MD analysis based on SATS, providing insights into binding mode and predicting binding sites.
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Analytical
Yu Su, Dandan Yang, Yanjie Wang, Jie Ding, Lan Ding, Daqian Song
Summary: In this study, a highly selective molecularly imprinted polymer Cu-MIPs@CS was designed and synthesized for bisphenol A (BPA). Cu-MIPs@CS showed significantly enhanced imprinting factor and selective factor towards BPA compared to MIPs@CS. It also exhibited superior discrimination ability between BPA and its structural analogue. Additionally, Cu-MIPs@CS were successfully applied as a solid phase extraction adsorbent for the determination of BPA in drinking water samples.
Article
Chemistry, Analytical
Yi Qiao, Qiongdan Zhang, Yukun He, Tianguang Cheng, Jing Tu
Summary: Single cell heterogeneity plays an important role in many biological phenomena, and distinguishing cells with specific mutations is beneficial for clinical diagnosis and drug screening. This study introduces a gel plate platform that can distinguish cell types based on their phenotypes, with low equipment requirement. The gel platform has potential in point-of-care circumstances and single-cell stimulation responses that prioritize efficiency and simplicity.
Article
Chemistry, Analytical
Chengke Wang, Shuyang Sun, Ping Wang, Huawei Zhao, Wenling Li
Summary: The food safety of aquatic products is a global concern. Nanotechnology-based analyses have advantages in the detection of bacteria, metal ions, and small molecule contaminants. This review summarizes the recent advances in biosensing strategies for aquatic products and highlights the application of nanomaterials, lateral flow-based biosensors, surface-enhanced Raman scattering, microfluidic chips, and molecular imprinting technologies.
Article
Chemistry, Analytical
Liping Zhu, Zeng Tang, Xuemei Zhang, Li Zhu, Tian Meng, Linying Yu, Ting Xiao, Shasha Lu, Xiaoli Xiong, Xiurong Yang
Summary: A sensitive off-on electrochemiluminescence DNA sensor was developed using Exo III-assisted cascade amplification system. The sensor achieved high selectivity and ultra-high sensitivity in detecting target DNA by utilizing ECL and SPR effects. This study provides a new perspective for designing highly sensitive and programmable ECL biosensors.
Article
Chemistry, Analytical
Tong Li, Mengxu Sun, Suping Xia, Ting Huang, Rong-Tian Li, Chunrong Li, Zong Dai, Jin-Xiang Chen, Jun Chen, Nuan Jia
Summary: Here, we developed a binary system based on DNA tetrahedron and fluorogenic RNA aptamers for highly specific and label-free mRNA imaging in living cells. This system achieved high specificity label-free detection of nucleic acids with a detection limit of 1.34 nM. The method has potential applications in early disease diagnosis and new drug development.
Article
Chemistry, Analytical
Yao Zhao, Shu Zhang, Wang Yao, Yuxuan Zhu, Jing Qian, Juan Yang, Nianjun Yang
Summary: A new hierarchical nanostructured composite with high conductivity and catalytic activity is synthesized. The sensor exhibits significant catalytic effect and high sensitivity for monitoring the environmental endocrine disruptor bisphenol A (BPA).