Article
Chemistry, Analytical
Yingzhou Tao, Weihao Shi, Fang Luo, Bin Qiu, Zhenyu Lin
Summary: Gold nanoparticles exhibit strong photothermal effect after aggregation induced by cysteine and are inhibited by copper ions, enabling detection of Cu2+ and development of a convenient photothermal immunoassay for cancer biomarker CEA.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Analytical
Xianxian Zhao, Ye Yuan, Xiaoya Liu, Fajiang Mao, Ge Xu, Qingzhong Liu
Summary: The development of a versatile and sensitive analytical biomarker detection platform is crucial for early disease diagnosis and treatment. In this study, a novel fluorescence-based, ultrasensitive, and label-free biomarker detection platform is proposed. This platform demonstrates high sensitivity and specificity, and shows great potential in clinical diagnosis and anticancer drug development.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Min Jiang, Jing Zhou, Xiaobo Xie, Zili Huang, Rui Liu, Yi Lv
Summary: This study established a novel nanoparticle counting strategy to simultaneously analyze three breast cancer-associated miRNAs for breast cancer diagnosis. The strategy showed great potential for cancer diagnosis with high sensitivity.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Min Jiang, Jing Zhou, Xiaobo Xie, Zili Huang, Rui Liu, Yi Lv
Summary: Liquid biopsy is a sought-after technique for disease diagnosis, providing real-time, dynamic, and comprehensive information. This novel nanoparticle counting strategy allows for simultaneous analysis of multiple miRNAs for breast cancer diagnosis, showing potential for significant impact in cancer diagnosis.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Xue Chen, Hongjie Song, Ziyan Li, Rui Liu, Yi Lv
Summary: This study achieved multiple evaluations of breast cancer biomarkers in human serum samples by designing and synthesizing multiple lanthanide nanoparticle tags, demonstrating wide linear ranges and low detection limit levels for all biomarkers in clinical applications.
ANALYTICAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Zhi Yao Ma, Cherry Sze Yan Chan, Kam Shing Lau, Lui Ng, Yuen Yee Cheng, Wai K. Leung
Summary: SEPT9 ddPCR showed good performance in CRC detection, and the rapid decline of methylated SEPT9 abundance 3 months after surgery may be helpful for monitoring treatment response.
SCIENTIFIC REPORTS
(2021)
Article
Materials Science, Biomaterials
Nanhang Zhu, Guohao Li, Juan Zhou, Yujia Zhang, Ke Kang, Binwu Ying, Qiangying Yi, Yao Wu
Summary: In this study, a FRET magnetic aptamer-sensor was developed for rapid and efficient detection of exosomes, with a detection limit of 13 particles per mL and 100% accuracy in screening a specific cancer antigen. This system shows promising potential for liquid biopsy in lung cancer detection.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Environmental Sciences
Peng Huang, Lingzhang Meng, Jun Pang, Haiting Huang, Jing Ma, Linlin He, Parnian Amani
Summary: This study successfully developed a label-free electrochemical immunosensor based on a metal-organic framework (MOF)-graphene oxide nanocomposite for the detection of carcinoembryonic antigen (CEA), a tumor marker in lung cancer for early cancer diagnosis. The immunosensor showed improved sensitivity, stability, and selectivity, and demonstrated satisfactory accuracy in detecting CEA in human serum samples. These findings suggest that the prepared CEA immunosensor has potential for clinical applications and analysis of human fluids.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biophysics
Chunling Mao, Lei Wu, Yi Wen, Ximing Tang, Zheng Huang, Longshan Zhao
Summary: A photoelectrochemical immunosensor based on MIL-101(Cr) and CdTe-QDs composites was synthesized to detect the carcinoembryonic antigen (CEA) in human serum and urine samples. The sensor demonstrated altered photocurrent polarity, improved light utilization efficiency, and enhanced separation efficiency of electron-hole pairs. Under optimized conditions, the sensor showed high sensitivity and stability, with detection limits of 0.00018 ng mL-1 and 0.00023 ng mL-1 for anodic and cathodic detection of CEA, respectively.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Analytical
Yi Gu, Yang Guo, Yang Deng, Haipeng Song, Rui Nian, Wenshuai Liu
Summary: A novel pentameric nanobodies-based immunoassay (PNIA) demonstrated superior sensitivity and high specificity for detecting CEACAM-5 antigen. The use of bispecific or multivalent nanobody design provided new insights into the development of immunoassays for clinical diagnosis.
ANALYTICA CHIMICA ACTA
(2023)
Article
Biochemical Research Methods
Nandini Debnath, Ludovic Saiveng Live, Mahla Poudineh
Summary: Biomarker detection in whole blood is important for understanding the disease. Current detection techniques have limitations, and there is a need for reliable and adaptable methods for point-of-care testing. We have developed a simple and low-cost protein detection device that can detect biomarkers in whole blood within 15 minutes. This technique has the potential to improve the diagnosis and screening of various diseases.
Article
Chemistry, Multidisciplinary
Chaoqun Wang, Ziqiang Deng, Hu Zhang, Rui Liu, Yi Lv
Summary: Magnetic particles (MPs) are widely used in various biological applications, and this study discovered a novel function of commercialized MPs-internal standard for accurate quantification of biomolecules. The proposed MPs-based immunoassay greatly improves the accuracy and precision by eliminating potential MPs loss and intensity fluctuations during magnetic separation.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Analytical
Xuwei Chen, Xuan Zheng, Xiangyong Yu, Xiaoqin Li, Youxiu Lin, Huizi Lin, Shuai Ye, Xinyu Huang, Dianping Tang, Wenqiang Lai
Summary: This study reports a simple and rapid colorimetric immunoassay for the determination of carcinoembryonic antigen (CEA) using Fe2O3 nanoparticle-based chromogenic substrate system. The assay is based on the rapid coordination of ascorbic acid 2-phosphate (AAP) and iron (III), resulting in color development. Fe2O3 nanoparticle is used as a label in a sandwich-type immunoassay, and the absorbance of the reaction solution is positively correlated with antigen concentration. The method shows good performance for CEA detection, with a wide detection range and a low detection limit, as well as acceptable repeatability, stability, and selectivity.
Article
Immunology
Christelle Kassis, Michelle Durkin, Eric Holbrook, Robert Myers, Lawrence Wheat
Summary: Combining antibody and antigen detection can improve sensitivity and specificity in the diagnosis of coccidioidomycosis, particularly with higher sensitivity in immunocompromised patients. Antigen detection can help prevent missed diagnoses.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Chemistry, Analytical
Xianlin Han, Shujin Lin, Cui Cheng, Xiao Han, Dianping Tang
Summary: This study presents an integrated photoelectrochemical, impedance and colorimetric biosensing platform for flexible detection of cancer markers by combining liposome amplification strategies and target-induced non-in situ formation of electronic barriers as the signal transduction modality. The platform enables high sensitivity detection through the amplification strategy of liposome-mediated enzymatic reaction.
ANALYTICA CHIMICA ACTA
(2023)
Article
Engineering, Electrical & Electronic
Esref Turkmen, Barbaros Cetindogan, Melik Yazici, Yasar Gurbuz
IEEE SENSORS JOURNAL
(2020)
Article
Engineering, Electrical & Electronic
Murat Davulcu, Abdurrahman Burak, Yasar Gurbuz
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS II-EXPRESS BRIEFS
(2020)
Article
Engineering, Electrical & Electronic
Can Caliskan, Melik Yazici, Mehmet Kaynak, Yasar Gurbuz
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS II-EXPRESS BRIEFS
(2020)
Article
Engineering, Electrical & Electronic
Abdurrahman Burak, Can Caliskan, Melik Yazici, Yasar Gurbuz
Summary: This paper presents an X-Band 6-bit multifunctional chip implemented in 0.25-micron SiGe BiCMOS technology, achieving a +12 dBm input-referred compression point (IP1dB) and flat gain profile. Various design techniques were used to enhance performance, providing technical support for system integration, with state-of-the-art performances at X-Band.
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS II-EXPRESS BRIEFS
(2021)
Article
Engineering, Electrical & Electronic
Can Calskan, Melik Yazici, Yasar Gurbuz
Summary: This paper presents an APN-based SiGe BiCMOS phase shifter achieving low RMS phase error and wide bandwidth by utilizing APNs and transformers in a compact design.
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS II-EXPRESS BRIEFS
(2021)
Article
Engineering, Electrical & Electronic
Ilker Kalyoncu, Abdurrahman Burak, Yasar Gurbuz
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS II-EXPRESS BRIEFS
(2020)
Review
Chemistry, Analytical
Seyed Mohammad Taghi Gharibzahedi, Francisco J. Barba, Jianjun Zhou, Min Wang, Zeynep Altintas
Summary: This study reviews the application of electronic sensing platforms in the assessment of tea quality. Advanced sensing technologies and data processing algorithms can accurately accelerate tea quality assessment and define new standards for tea products. Feature-level fusion strategy can improve the accuracy of prediction models.
Article
Biochemistry & Molecular Biology
Seyed Mohammad Taghi Gharibzahedi, Zeynep Altintas
Summary: The study optimized the ultrasound-assisted extraction of oil from lesser mealworm larvae powders using ethanol/isopropanol as the superior solvent, achieving the highest extraction efficiency and in vitro antioxidant activity at a solvent-to-LMLPs ratio of 22.5 v/w and 70°C. The oil diffusivity in ethanol-isopropanol during the extraction process was significantly better than that of n-hexane, resulting in improved efficiency. Additionally, the improved antioxidant activity was associated with higher total phenolic and carotenoid contents in the extracted oil, suggesting enhanced oxidative stability.
Article
Chemistry, Analytical
Sunil Choudhary, Zeynep Altintas
Summary: A novel point-of-care surface plasmon resonance (SPR) sensor was developed for sensitive and real-time detection of cardiac troponin I (cTnI) using epitope-imprinted molecular receptors. The sensor showed high specificity for the target biomarker and had the potential to be used for early and point-of-care testing of acute myocardial infarction and other life-threatening diseases.
Article
Chemistry, Analytical
Aabha Bajaj, Jakob Trimpert, Ibrahim Abdulhalim, Zeynep Altintas
Summary: This study demonstrates the potential of using molecularly imprinted polymer nanoparticles as plastic antibodies for the specific detection of SARS-CoV-2. The results show that this method can detect SARS-CoV-2 particles with high affinity and specificity, and has the potential to be applied in monitoring and managing the risks related to virus contamination and infections.
Article
Biochemistry & Molecular Biology
Carmen Andreina Olivares Moreno, Zeynep Altintas
Summary: This study successfully developed a bioselective polyethersulfone (PES) membrane by combining chitosan hydrophilic surface modification and the immobilization of adenovirus-specific molecularly imprinted nanoparticles (nanoMIPs), achieving excellent virus removal capabilities in water.
Article
Chemistry, Analytical
Kadir Erol, Gauri Hasabnis, Zeynep Altintas
Summary: Simple, fast, selective, and reliable detection of human epidermal growth factor receptor 2 (HER2) is crucial for early diagnosis of breast cancer. Molecularly imprinted polymers (MIPs) have been used as a specific tool in cancer diagnosis and therapy. In this study, a miniaturized surface plasmon resonance (SPR)-based sensor was developed using HER2-nanoMIPs, which showed excellent selectivity and sensitivity for HER2 detection in human serum.
Article
Polymer Science
Seyed Mohammad Taghi Gharibzahedi, Zeynep Altintas
Summary: There is a high demand for designing healthy-functional dairy gels with a newly structured protein network in the food industry. Non-fat yogurt gels enriched with stable tarragon essential oil-nanoemulsions (TEO-NEs) using crosslinking of microbial transglutaminase (MTGase) were developed. The optimal yogurt gel as a nutritious diet not only provided the highest organoleptic scores but also maintained its storage-related quality with the lowest mold/yeast growth and free-radical oxidation changes.
Proceedings Paper
Engineering, Electrical & Electronic
Tahsin Alper Ozkan, Abdurrahman Burak, Ilker Kalyonc, Mehmet Kaynak, Yasar Gurbuz
Summary: This paper presents a low noise amplifier (LNA) implemented in a SiGe BiCMOS technology for 5G applications. The LNA is based on a two-stage cascode amplifier topology with innovative designs in noise and power matching, achieving high gain and low power consumption. This work achieves the highest figure of merit (FoM) among compared works, attributing to the design of the two-stage cascode topology.
2020 15TH EUROPEAN MICROWAVE INTEGRATED CIRCUITS CONFERENCE (EUMIC)
(2021)
Proceedings Paper
Engineering, Electrical & Electronic
C. Baristiran Kaynak, A. Goeritz, E. C. Durmaz, M. Wietstruck, E. Onat, A. S. Ozcan, E. R. Turkoglu, Y. Gurbuz, M. Kaynak
2020 IEEE 20TH TOPICAL MEETING ON SILICON MONOLITHIC INTEGRATED CIRCUITS IN RF SYSTEMS (SIRF)
(2020)
Article
Chemistry, Analytical
Qian Wu, Li Tian, Xiangyu Shan, Huiling Li, Chao Li, Juan Lu
Summary: A novel ECL sensor was developed by modifying Fe3CuO4-Ru(bpy)3+ and GO-CdS@ZnS on the electrode for the detection of permethrin. The sensor exhibited high sensitivity and a wide detection range.
Article
Chemistry, Analytical
Tingting Gong, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescent biosensing system for high sensitivity detection of MT was established using a new Ag+-stabilized DNA triplex probe (Ag+-SDTP) combined with catalytic hairpin assembly (CHA) and CRISPR/Cas12a signal enhancements. The sensing method is able to selectively detect MT from other non-specific molecules and can achieve low level detection of MT in diluted human serums, demonstrating its potential for monitoring disease-specific MT biomarker at trace levels.
Article
Chemistry, Analytical
Estrella Sanz Rodriguez, Kyra Wood, Paul R. Haddad, Brett Paull
Summary: This study presents a simple, rapid, and reliable method for determining boron in aqueous solutions using suppressed ion chromatography coupled to electrospray ionisation-triple quadrupole mass spectrometry. The method achieved a low limit of detection and demonstrated excellent analytical performance.
Article
Chemistry, Analytical
Aline Cournut, Paul Moustiez, Yannick Coffinier, Christine Enjalbal, Claudia Bich
Summary: Alzheimer's disease is a major cause of senile dementia and is characterized by the aggregation of neurofibrillary tangles and amyloid plaques in the brain. The A beta 1-42 peptide is considered the primary cause of neurotoxicity due to its insolubility and subsequent aggregation. A beta 1-42 and A beta 1-40 have been identified as relevant biomarkers for AD diagnosis, and SurfaceAssisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) was used to monitor the A beta 1-42/A beta 1-40 ratio without prior sample treatment.
Article
Chemistry, Analytical
Dotse Selali Chormey, Buse Tugba Zaman, Tulay Borahan Kustanto, Sezin Erarpat Bodur, Suleyman Bodur, Elif Ozturk Er, Sezgin Bakirdere
Summary: This review provides an overview of the harmful effects of endocrine disrupting chemicals (EDCs) on human health and introduces the methods for analyzing EDCs. Recent research has focused on using green chemicals, such as deep eutectic solvents (DESs), for microextraction to ensure environmental safety.
Article
Chemistry, Analytical
Yan Zhang, Renfeng Xu, Jingjing Wu, Zhenghong Zhang, Yuhuang Wang, Hongqin Yang, Sheng Zhang
Summary: This study visualized the pore-like structures in prostate cancer cell membranes after treatment with the anticancer drug paclitaxel, demonstrating its mechanism of action related to oxidative damage.
Article
Chemistry, Analytical
Chihong Ma, Qin Zhou, Jinjin Shi, Hua Gao, Di Huang, Huimin Xue, Han Wang, Zhenzhong Zhang, Sen Yang, Junli Zhang, Kaixiang Zhang
Summary: We developed a CRISPR-empowered electrochemical biosensor, named PER-E-CRISPR, for amplification-free and sensitive detection of miR-21. The biosensor combines the advantages of CRISPR/Cas13a and primer exchange reaction (PER) for target amplification. Under optimized conditions, the PER-E-CRISPR assay exhibits a linear range from 10-13 to 10-7 M and a limit of detection of 30.2 fM. The biosensor shows excellent performance in actual plasma, indicating promising prospects for miRNA detection in molecular diagnosis.
Article
Chemistry, Analytical
Gang Liang, Jie Zhao, Yufei Gao, Tao Xie, Jianhui Zhen, Ligang Pan, Wenwen Gong
Summary: Molecular docking (MD) analysis is widely used for studying the interaction between aptamers and small molecules. This study established steady-state aptamers of tertiary structures (SATS) using specific aptamers of tetracycline antibiotics as docking models. Molecular docking results revealed multiple binding sites in the SATS of aptamers, with significant variations in binding free energy (BFE) and docking score (DS). The study also proposed a method for MD analysis based on SATS, providing insights into binding mode and predicting binding sites.
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Analytical
Yu Su, Dandan Yang, Yanjie Wang, Jie Ding, Lan Ding, Daqian Song
Summary: In this study, a highly selective molecularly imprinted polymer Cu-MIPs@CS was designed and synthesized for bisphenol A (BPA). Cu-MIPs@CS showed significantly enhanced imprinting factor and selective factor towards BPA compared to MIPs@CS. It also exhibited superior discrimination ability between BPA and its structural analogue. Additionally, Cu-MIPs@CS were successfully applied as a solid phase extraction adsorbent for the determination of BPA in drinking water samples.
Article
Chemistry, Analytical
Yi Qiao, Qiongdan Zhang, Yukun He, Tianguang Cheng, Jing Tu
Summary: Single cell heterogeneity plays an important role in many biological phenomena, and distinguishing cells with specific mutations is beneficial for clinical diagnosis and drug screening. This study introduces a gel plate platform that can distinguish cell types based on their phenotypes, with low equipment requirement. The gel platform has potential in point-of-care circumstances and single-cell stimulation responses that prioritize efficiency and simplicity.
Article
Chemistry, Analytical
Chengke Wang, Shuyang Sun, Ping Wang, Huawei Zhao, Wenling Li
Summary: The food safety of aquatic products is a global concern. Nanotechnology-based analyses have advantages in the detection of bacteria, metal ions, and small molecule contaminants. This review summarizes the recent advances in biosensing strategies for aquatic products and highlights the application of nanomaterials, lateral flow-based biosensors, surface-enhanced Raman scattering, microfluidic chips, and molecular imprinting technologies.
Article
Chemistry, Analytical
Liping Zhu, Zeng Tang, Xuemei Zhang, Li Zhu, Tian Meng, Linying Yu, Ting Xiao, Shasha Lu, Xiaoli Xiong, Xiurong Yang
Summary: A sensitive off-on electrochemiluminescence DNA sensor was developed using Exo III-assisted cascade amplification system. The sensor achieved high selectivity and ultra-high sensitivity in detecting target DNA by utilizing ECL and SPR effects. This study provides a new perspective for designing highly sensitive and programmable ECL biosensors.
Article
Chemistry, Analytical
Tong Li, Mengxu Sun, Suping Xia, Ting Huang, Rong-Tian Li, Chunrong Li, Zong Dai, Jin-Xiang Chen, Jun Chen, Nuan Jia
Summary: Here, we developed a binary system based on DNA tetrahedron and fluorogenic RNA aptamers for highly specific and label-free mRNA imaging in living cells. This system achieved high specificity label-free detection of nucleic acids with a detection limit of 1.34 nM. The method has potential applications in early disease diagnosis and new drug development.
Article
Chemistry, Analytical
Yao Zhao, Shu Zhang, Wang Yao, Yuxuan Zhu, Jing Qian, Juan Yang, Nianjun Yang
Summary: A new hierarchical nanostructured composite with high conductivity and catalytic activity is synthesized. The sensor exhibits significant catalytic effect and high sensitivity for monitoring the environmental endocrine disruptor bisphenol A (BPA).
