Article
Nutrition & Dietetics
Yu-Tang Tung, Chieh-Hsi Wu, Wen-Chao Chen, Chun-Hsu Pan, Yi-Wen Chen, Shu-Ping Tsao, Chia-Jung Chen, Hui-Yu Huang
Summary: This study found that phlorotannins from Ascophyllum nodosum and Fucus vesiculosus significantly reduced blood sugar, cholesterol, and triglyceride levels in rats with hyperlipidemia. It also increased insulin and high-density lipoprotein cholesterol levels while promoting lipase activity. Moreover, phlorotannins reduced adipocyte size, decreased inflammatory factors, and increased antioxidant enzyme activity. These results suggest that Ascophyllum nodosum and Fucus vesiculosus could be potential sources of anti-hyperlipidemia drugs and functional foods.
Article
Agronomy
Sorin Ciulca, Gheorghe Roma, Ersilia Alexa, Isidora Radulov, Ileana Cocan, Emilian Madosa, Adriana Ciulca
Summary: This study evaluated the total polyphenol content and antioxidant activity of fruits in six wild bilberry populations from Romania over three years. Results showed significant differences in polyphenol content and antioxidant activity between populations from different regions and across years, indicating the impact of environmental conditions on the accumulation of polyphenols in bilberry fruits.
Article
Chemistry, Medicinal
Mauro Gisbert, Jorge Sineiro, Ramon Moreira
Summary: The isolation and chemical characterization of phlorotannins have gained attention recently due to their health-promoting benefits. This study used flow-cell ultrasound-assisted extraction with different solvents to extract phlorotannins from algae. The results showed that the acetone:water mixture had higher polyphenols content, carbohydrates, and antioxidant activities compared to double-distilled water. Purification of the double-distilled water extract led to similar polyphenols content, decreased carbohydrates, and increased antioxidant activity. The oxidation process of the purified extract was also investigated, with severe oxidation conditions having the most significant impact on reducing polyphenols and antioxidant activities. Dialysis of the purified extract resulted in the main bioactive fraction of phlorotannins being obtained from 10 to 20 kDa. Analysis of the extracted compounds revealed the presence of phlorotannins in the Ascophyllum nodosum extracts.
Article
Multidisciplinary Sciences
Syed Anees Ali Jafri, Zafar Mehmood Khalid, Mohammad Rizwan Khan, Sadia Ashraf, Naushad Ahmad, Abdulnasser Mahmoud Karami, Ejaz Rafique, Mohamed Ouladsmane, Nouf Mohammad Saad Al Suliman, Summan Aslam
Summary: This study evaluated the antioxidant activities of extracts from different parts of traditionally used medicinal plants. The results showed that Euphrasiae stricta and Euphorbia platyphyllos L. had high levels of phenolic and flavonoid compounds and strong free radical scavenging activity. The highest antioxidant activity was observed in Euphrasiae stricta. These findings suggest that these medicinal plants can be used as important antioxidants for treating and inhibiting degenerative diseases caused by oxidative stress.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Roya R. R. Sardari, Jens Prothmann, Olavur Gregersen, Charlotta Turner, Eva Nordberg Karlsson
Summary: This study aimed to identify phlorotannin molecules from Saccharina latissima and Ascophyllum nodosum using advanced analytical techniques, and found a potential interference issue from non-phenolic compounds in the extracts.
Article
Engineering, Environmental
Klara Rusevova Crincoli, Scott G. Huling
Summary: For the first time, the fate of radicals in heterogeneous chemical oxidation treatment systems was studied, with UV-AHP and UV-APS generating center dot OH and SO4 center dot- radicals that impact treatment efficiency. The higher scavenging rates of center dot OH by alumina and aqueous/solid phase constituents, compared to SO4 center dot-, contributed to lower treatment efficiency in the UV-AHP system. The cost assessment based on overall treatment efficiency showed higher specific cost for treating the probe compound with UV-AHP due to its lower treatment efficiency compared to UV-APS.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Yang Li, Hanqiao Liang, Dongyu Zhou, Yongmei Xing, Juan Chen
Summary: This study analyzed the chemical composition and antioxidant activity of Tuber indicum at different maturity stages in China. The results showed that Tuber indicum in the early maturity stage had higher levels of phenolic and flavonoid compounds and stronger antioxidant activity.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Food Science & Technology
Nurain Rahman, Kaiser Mahmood, Hanisah Kamilah, Syazana Sulaiman, Muhammad Ibrahim, Fazilah Ariffin
Summary: The study evaluated the effects of blanching and pickling on nutmeg pericarp, finding that these treatments significantly reduced AAT activity and myristicin content, while improving the overall quality of nutmeg.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2022)
Article
Biochemistry & Molecular Biology
Chiara La Torre, Alessia Fazio, Paolino Caputo, Pierluigi Plastina, Maria Cristina Caroleo, Roberto Cannataro, Erika Cione
Summary: Kombucha, a fermented beverage, has become increasingly popular due to its perceived beneficial effects, but its antioxidant properties decline significantly after four months of storage.
Article
Materials Science, Multidisciplinary
Citlali Alejandra Marin-Flores, Odin Rodriguez-Nava, Margarita Garcia-Hernandez, Rosario Ruiz-Guerrero, Fernando Juarez-Lopez, Angel de Jesus Morales-Ramirez
Summary: ZnO particles were synthesized and their free radical scavenging activity properties were evaluated in this study. The results showed that the scavenging activity increased with smaller particle size and lower ZnO dosage. A pseudo-first-order kinetics model may be present in the reaction.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2021)
Article
Chemistry, Applied
Jin-Lin Wan, Jing-Mei Huang
Summary: An electrochemical oxidative approach for the synthesis of spirooxazolidinones from phenol derivatives via intramolecular dearomative amination reactions is developed. This reaction does not require the use of metal catalysts or external chemical oxidants, and exhibits a broad substrate scope and compatibility with diverse functional groups. The synthetic utility of this strategy is demonstrated through gram-scale synthesis and late-stage functionalization. Additionally, the reaction conditions can be adjusted to produce alcohols (1˚, 2˚, and 3˚) from phenol derivatives, offering a useful strategy for deprotecting the para-methoxyphenyl (PMP) group and recovering the alcohol functionality.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Plant Sciences
Eleftherios Kalpoutzakis, Theodoros Chatzimitakos, Vassilis Athanasiadis, Sofia Mitakou, Nektarios Aligiannis, Eleni Bozinou, Olga Gortzi, Leandros A. Skaltsounis, Stavros I. Lalas
Summary: Oxidative damages are harmful to health and food quality. Plant-derived antioxidants, such as those found in extracts from certain plant species in Greece, have high phenolic content and strong antioxidant activity. These plants can be used as food additives or for the preparation of food supplements with antioxidant properties.
Article
Chemistry, Multidisciplinary
Hengli Lu, Jihu Wei, Kaiyuan Liu, Zihua Li, Tianyang Xu, Dong Yang, Qiuming Gao, Huijing Xiang, Guodong Li, Yu Chen
Summary: A dual-functional medication has been developed to protect cartilage and repair subchondral bone simultaneously. Black phosphorus nanosheets (BPNSs) effectively eliminate intracellular reactive oxygen species (ROS), restore chondrocyte function, and regulate inflammation, providing disease-modifying effects on osteoarthritis (OA). In vivo assessments confirm that BPNSs inhibit cartilage degradation and prevent OA progression, making them a competitive candidate for OA treatment.
Article
Materials Science, Ceramics
Zhaojun Qi, Sen Wang, Yan Li, Lifeng Wang, Lin Zhao, Qiang Ge, Jin Zhong Zhang
Summary: The novel free radical scavenger ML-Ti3C2Tx MXene exhibits high scavenging efficiency due to its intrinsic reducing property, rather than hydrogen donation ability from surface functional groups. The observed scavenging activity is attributed to the reducing property of ML-Ti3C2Tx, as compared to other materials.
CERAMICS INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Gorka Calvo-Martin, Daniel Plano, Ignacio Encio, Carmen Sanmartin
Summary: A series of 30 novel N,N-disubstituted selenoureas were synthesized and tested for their antioxidant and cytotoxic activities. Some compounds showed potential anti-cancer properties, with selenourea 6c demonstrating promising anticancer activity in the NCI60 cell line panel.
Article
Chemistry, Analytical
Qian Wu, Li Tian, Xiangyu Shan, Huiling Li, Chao Li, Juan Lu
Summary: A novel ECL sensor was developed by modifying Fe3CuO4-Ru(bpy)3+ and GO-CdS@ZnS on the electrode for the detection of permethrin. The sensor exhibited high sensitivity and a wide detection range.
Article
Chemistry, Analytical
Tingting Gong, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescent biosensing system for high sensitivity detection of MT was established using a new Ag+-stabilized DNA triplex probe (Ag+-SDTP) combined with catalytic hairpin assembly (CHA) and CRISPR/Cas12a signal enhancements. The sensing method is able to selectively detect MT from other non-specific molecules and can achieve low level detection of MT in diluted human serums, demonstrating its potential for monitoring disease-specific MT biomarker at trace levels.
Article
Chemistry, Analytical
Estrella Sanz Rodriguez, Kyra Wood, Paul R. Haddad, Brett Paull
Summary: This study presents a simple, rapid, and reliable method for determining boron in aqueous solutions using suppressed ion chromatography coupled to electrospray ionisation-triple quadrupole mass spectrometry. The method achieved a low limit of detection and demonstrated excellent analytical performance.
Article
Chemistry, Analytical
Aline Cournut, Paul Moustiez, Yannick Coffinier, Christine Enjalbal, Claudia Bich
Summary: Alzheimer's disease is a major cause of senile dementia and is characterized by the aggregation of neurofibrillary tangles and amyloid plaques in the brain. The A beta 1-42 peptide is considered the primary cause of neurotoxicity due to its insolubility and subsequent aggregation. A beta 1-42 and A beta 1-40 have been identified as relevant biomarkers for AD diagnosis, and SurfaceAssisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) was used to monitor the A beta 1-42/A beta 1-40 ratio without prior sample treatment.
Article
Chemistry, Analytical
Dotse Selali Chormey, Buse Tugba Zaman, Tulay Borahan Kustanto, Sezin Erarpat Bodur, Suleyman Bodur, Elif Ozturk Er, Sezgin Bakirdere
Summary: This review provides an overview of the harmful effects of endocrine disrupting chemicals (EDCs) on human health and introduces the methods for analyzing EDCs. Recent research has focused on using green chemicals, such as deep eutectic solvents (DESs), for microextraction to ensure environmental safety.
Article
Chemistry, Analytical
Yan Zhang, Renfeng Xu, Jingjing Wu, Zhenghong Zhang, Yuhuang Wang, Hongqin Yang, Sheng Zhang
Summary: This study visualized the pore-like structures in prostate cancer cell membranes after treatment with the anticancer drug paclitaxel, demonstrating its mechanism of action related to oxidative damage.
Article
Chemistry, Analytical
Chihong Ma, Qin Zhou, Jinjin Shi, Hua Gao, Di Huang, Huimin Xue, Han Wang, Zhenzhong Zhang, Sen Yang, Junli Zhang, Kaixiang Zhang
Summary: We developed a CRISPR-empowered electrochemical biosensor, named PER-E-CRISPR, for amplification-free and sensitive detection of miR-21. The biosensor combines the advantages of CRISPR/Cas13a and primer exchange reaction (PER) for target amplification. Under optimized conditions, the PER-E-CRISPR assay exhibits a linear range from 10-13 to 10-7 M and a limit of detection of 30.2 fM. The biosensor shows excellent performance in actual plasma, indicating promising prospects for miRNA detection in molecular diagnosis.
Article
Chemistry, Analytical
Gang Liang, Jie Zhao, Yufei Gao, Tao Xie, Jianhui Zhen, Ligang Pan, Wenwen Gong
Summary: Molecular docking (MD) analysis is widely used for studying the interaction between aptamers and small molecules. This study established steady-state aptamers of tertiary structures (SATS) using specific aptamers of tetracycline antibiotics as docking models. Molecular docking results revealed multiple binding sites in the SATS of aptamers, with significant variations in binding free energy (BFE) and docking score (DS). The study also proposed a method for MD analysis based on SATS, providing insights into binding mode and predicting binding sites.
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Analytical
Yu Su, Dandan Yang, Yanjie Wang, Jie Ding, Lan Ding, Daqian Song
Summary: In this study, a highly selective molecularly imprinted polymer Cu-MIPs@CS was designed and synthesized for bisphenol A (BPA). Cu-MIPs@CS showed significantly enhanced imprinting factor and selective factor towards BPA compared to MIPs@CS. It also exhibited superior discrimination ability between BPA and its structural analogue. Additionally, Cu-MIPs@CS were successfully applied as a solid phase extraction adsorbent for the determination of BPA in drinking water samples.
Article
Chemistry, Analytical
Yi Qiao, Qiongdan Zhang, Yukun He, Tianguang Cheng, Jing Tu
Summary: Single cell heterogeneity plays an important role in many biological phenomena, and distinguishing cells with specific mutations is beneficial for clinical diagnosis and drug screening. This study introduces a gel plate platform that can distinguish cell types based on their phenotypes, with low equipment requirement. The gel platform has potential in point-of-care circumstances and single-cell stimulation responses that prioritize efficiency and simplicity.
Article
Chemistry, Analytical
Chengke Wang, Shuyang Sun, Ping Wang, Huawei Zhao, Wenling Li
Summary: The food safety of aquatic products is a global concern. Nanotechnology-based analyses have advantages in the detection of bacteria, metal ions, and small molecule contaminants. This review summarizes the recent advances in biosensing strategies for aquatic products and highlights the application of nanomaterials, lateral flow-based biosensors, surface-enhanced Raman scattering, microfluidic chips, and molecular imprinting technologies.
Article
Chemistry, Analytical
Liping Zhu, Zeng Tang, Xuemei Zhang, Li Zhu, Tian Meng, Linying Yu, Ting Xiao, Shasha Lu, Xiaoli Xiong, Xiurong Yang
Summary: A sensitive off-on electrochemiluminescence DNA sensor was developed using Exo III-assisted cascade amplification system. The sensor achieved high selectivity and ultra-high sensitivity in detecting target DNA by utilizing ECL and SPR effects. This study provides a new perspective for designing highly sensitive and programmable ECL biosensors.
Article
Chemistry, Analytical
Tong Li, Mengxu Sun, Suping Xia, Ting Huang, Rong-Tian Li, Chunrong Li, Zong Dai, Jin-Xiang Chen, Jun Chen, Nuan Jia
Summary: Here, we developed a binary system based on DNA tetrahedron and fluorogenic RNA aptamers for highly specific and label-free mRNA imaging in living cells. This system achieved high specificity label-free detection of nucleic acids with a detection limit of 1.34 nM. The method has potential applications in early disease diagnosis and new drug development.
Article
Chemistry, Analytical
Yao Zhao, Shu Zhang, Wang Yao, Yuxuan Zhu, Jing Qian, Juan Yang, Nianjun Yang
Summary: A new hierarchical nanostructured composite with high conductivity and catalytic activity is synthesized. The sensor exhibits significant catalytic effect and high sensitivity for monitoring the environmental endocrine disruptor bisphenol A (BPA).