Article
Clinical Neurology
Yasuhiko Baba, Akinori Futamura, Ryuta Kinno, Shohei Nomoto, Seiya Takahashi, Taro Yasumoto, Yuyuko Osakabe, Daiki Shoji, Yoko Nabeshima
Summary: This study assessed the duration from initiation of levodopa/DCI to the emergence of motor fluctuations in patients with PD and found that levodopa/carbidopa therapy with a DCI to levodopa ratio of 1:10 may delay the occurrence of motor fluctuations when compared to levodopa/benserazide therapy with that of 1:4.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Chemistry, Applied
Yhan S. Mutz, Denes do Rosario, Luiz R. G. Silva, Diego Galvan, Jessica S. Stefano, Bruno C. Janegitz, David A. Weitz, Patricia C. Bernardes, Carlos A. Conte-Junior
Summary: Analytical methods such as chemometrics and electrochemical techniques, coupled with 3D printed sensors, offer a low-cost and efficient way to ensure the authenticity and quality of coffee. These methods can accurately classify different Brazilian coffees from regions with geographical indication (GI) and detect the blending of GI coffee with traditional coffee.
Article
Cell Biology
Thomas Mueller, Eugen Schlegel, Stephanie Zingler, Hans Michael Thiede
Summary: The catechol-O-methyltransferase inhibitors entacapone and opicapone prolong the efficacy of conventional oral levodopa/dopa decarboxylase inhibitor formulations through an increase in levodopa plasma bioavailability. The study compared the impact of single-day entacapone or opicapone intake on the pharmacokinetic plasma behavior of levodopa, 3-O-methyldopa, and total homocysteine in Parkinson's disease patients. It was found that opicapone had higher levodopa bioavailability and better baseline scores compared to entacapone.
Review
Pharmacology & Pharmacy
De-Qi Jiang, Qing-Min Zang, Li-Lin Jiang, Yan Wang, Ming-Xing Li, Jing-Yi Qiao
Summary: The study found that the clinical efficacy of P+LB combination therapy in Parkinson's disease patients is superior to that of LB monotherapy, with a better safety profile.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Clinical Neurology
Rajesh Pahwa, Jason Aldred, Niodita Gupta, Emi Terasawa, Viviana Garcia-Horton, David R. Steffen, Prasanna L. Kandukuri, Vivek S. Chaudhari, Yash J. Jalundhwala, Yanjun Bao, Pavnit Kukreja, Stuart H. Isaacson
Summary: In advanced Parkinson's disease, patients' motor-symptom states and the timing at which they occur can impact patients' quality of life and ability to complete activities of daily living. Carbidopa/levodopa enteral suspension may provide more consistent motor-symptom control throughout the day compared to orally administered carbidopa/levodopa.
NEUROLOGY AND THERAPY
(2022)
Article
Ophthalmology
Kate Thomson, Ian Morgan, Tamsin Kelly, Cindy Karouta, Regan Ashby
Summary: The combination of levodopa and carbidopa has a greater inhibitory effect on form-deprivation myopia and lens-induced myopia than levodopa alone. Topical application is more effective than systemic administration, with levodopa:carbidopa increasing vitreal dopamine levels the most significantly. Systemic administration leads to a significant increase in blood dopamine levels, while cotreatment with a dopamine antagonist inhibits the antimyopic effects of levodopa and levodopa:carbidopa.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Clinical Neurology
Marta Melis, Sarah Vascellari, Maria Laura Santoru, Valentina Oppo, Margherita Fabbri, Marianna Sarchioto, Daniela Murgia, Maurizio Zibetti, Leonardo Lopiano, Alessandra Serra, Vanessa Palmas, Silvia Pisanu, Daniela Perra, Veronica Madau, Roberto Cusano, Paolo Uva, Alessandra Mereu, Paolo Contu, Micaela Morelli, Luigi Atzori, Maurizio Melis, Aldo Manzin, Giovanni Cossu
Summary: The study suggests that levodopa and levodopa-carbidopa intestinal gel may significantly influence the composition of gut microbiota and host/bacteria metabolism in Parkinson's disease patients, potentially leading to a specific inflammatory intestinal microenvironment.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Health Care Sciences & Services
Mezin Othman, Erik Widman, Ingela Nygren, Dag Nyholm
Summary: Patients in fluctuating stages of Parkinson's disease benefit from device-aided treatments such as continuous infusion of levodopa-carbidopa intestinal gel (LCIG). This study reports the first clinical experience of levodopa-entacapone-carbidopa intestinal gel (LECIG) therapy, showing potential for use in PD patients. Despite overall satisfaction with the size and usability of the pump, some patients experienced side effects and improvements in software technology are needed.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Behavioral Sciences
K. Amande M. Pauls, Jussi Toppila, Maija Koivu, Johanna Eerola-Rautio, Marianne Udd, Eero Pekkonen
Summary: The study found that 10.5% of PD patients in Finland developed new-onset polyneuropathy after starting treatment with LCIG. Additionally, patients who experienced significant weight loss greater than 1.5 were more likely to develop neuropathy, while oral B-vitamin substitution may help prevent polyneuropathy related to LCIG treatment.
BRAIN AND BEHAVIOR
(2021)
Review
Pharmacology & Pharmacy
Sheila A. Doggrell
Summary: Parkinson's disease (PD) is a common neurodegenerative disease and the standard treatment is oral medication. However, as the disease progresses, the effectiveness of oral medication decreases, leading to motor fluctuations and dyskinesia. This article discusses the development of subcutaneous preparations for the treatment of motor fluctuations in PD, which show promising results in reducing symptoms.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Article
Ophthalmology
David G. Morrison, Gena Heidary, Melinda Y. Chang, Gil Binenbaum, Kara M. Cavuoto, Jennifer Galvin, Rupal Trivedi, Stephen J. Kim, Stacy L. Pineles, Andre Ambrus
Summary: This review examines the use of levodopa/carbidopa to enhance the treatment of amblyopia. The evidence suggests that oral administration of levodopa/carbidopa can improve the vision of amblyopic children, but the effect is small and regression of vision may occur after discontinuation of therapy. Short-term side effects are generally mild and long-term adverse effects were not observed in the studies reviewed.
Article
Clinical Neurology
Sandeep Thakkar, Victor S. C. Fung, Aristide Merola, Meredith Rollins, Michael J. Soileau, Norbert Kovacs
Summary: The infusion of LCIG is a standard treatment for advanced Parkinson's disease, and extending it to 24 hours may further alleviate symptoms. However, studies on 24-hour infusion are limited by small sample sizes and study designs. Clinical experience suggests that some patients may benefit from 24-hour infusion, but dose adjustments and monitoring are necessary.
Article
Behavioral Sciences
Noriyuki Miyaue, Madoka Kubo, Masahiro Nagai
Summary: Ascorbic acid can mitigate the degradation of carbidopa induced by MgO and may contribute to improving the bioavailability of levodopa in patients with PD.
BRAIN AND BEHAVIOR
(2022)
Article
Health Care Sciences & Services
Helga Maria Gretarsdottir, Erik Widman, Anders Johansson, Dag Nyholm
Summary: The study evaluated the individual experience of LC-5 in clinical practice, showing that the majority of patients reported symptom improvement with favorable usability. The results suggest that LC-5 therapy is generally well-tolerated and may offer a personalized approach for fine-tuned PD treatment.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Clinical Neurology
A. S. Blaise, E. Cuvelier, N. Carriere, D. Devos, F. Moreau, L. Defebvre, E. Mutez
Summary: This study evaluated the safety of levodopa-carbidopa intestinal gel (LCIG) in patients with the parkinsonian variant of multiple system atrophy (MSA-P). The results showed that LCIG treatment was effective and safe for MSA-P patients with severe motor complications, and the safety profile was similar to that seen in Parkinson's disease patients.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Chemistry, Applied
Jan Bergmann, Jaime Tapia, Manuel Bravo, Tania Zaviezo, M. Fernanda Flores
NATURAL PRODUCT RESEARCH
(2019)
Article
Chemistry, Analytical
Alicia Osorio, Carla Toledo-Neira, Manuel A. Bravo
Article
Environmental Sciences
Pablo A. Perez, Holger Hintelmann, Gabriela Lobos, Manuel A. Bravo
Article
Chemistry, Analytical
Manuel A. Bravo, Albani Gonzalez L, Barbara Valverde O, Waldo Quiroz, Carla Toledo-Neira
MICROCHEMICAL JOURNAL
(2019)
Article
Biochemical Research Methods
Paulina Godoy Arias, Hector Martinez-Perez-Cejuela, Audrey Combes, Valerie Pichon, Eduardo Pereira, Jose Manuel Herrero-Martinez, Manuel Bravo
JOURNAL OF CHROMATOGRAPHY A
(2020)
Article
Geosciences, Multidisciplinary
J. Tapia, B. Schneider, M. Inostroza, F. Alvarez-Amado, J. A. Luque, F. Aguilera, S. Parra, M. Bravo
Summary: Compilation of data on water, sediment, rock, and condensed gas in the Altiplano-Puna of Chile indicates a natural enrichment of arsenic (As) tied to volcanic activity, high crustal thicknesses, and regional structures. Analysis reveals a positive correlation between As concentrations in saline and brackish water of salt flats and crustal thicknesses, with higher values observed in eastern regions.
JOURNAL OF SOUTH AMERICAN EARTH SCIENCES
(2021)
Article
Chemistry, Analytical
Rodrigo Veneciano, V Sonnia Parra, Waldo Quiroz, Edwar Fuentes, Luis F. Aguilar, Manuel A. Bravo
MICROCHEMICAL JOURNAL
(2020)
Article
Chemistry, Physical
Marco Mellado, Rafaela Sariego-Kluge, Franco Valdes-Navarro, Rodrigo Sanchez-Gonzalez, Mauricio Fuentealba, Manuel A. Bravo, Luis F. Aguilar
Summary: The study synthesized a new pyrimidine core compound from chalcone, with fluorescence properties strongly influenced by solvent polarity. Quantum yields were notably higher in toluene and CH2Cl2, likely due to their high optical density.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Environmental Sciences
Jaime Tapia-Gatica, Ivan Selles, Manuel A. Bravo, Catherine Tessini, Wilson Barros-Parada, Alexey Novoselov, Alexander Neaman
Summary: This study evaluates the risks of arsenic, copper, zinc, and lead contamination in the soil of two important mining areas in Chile and finds that arsenic poses the highest risk. Chile currently lacks specific legislation on legal limits for soil contamination by trace elements, but it is necessary to establish background concentrations and develop national legislation to regulate soil metal contamination.
Article
Biochemical Research Methods
Marco Mellado, Nicole Roldan, Rodrigo Miranda, Luis F. Aguilar, Manuel A. Bravo, Waldo Quiroz
Summary: In this research, a novel fluorescent substance chalcone was synthesized and its ability to detect mercury ions in aqueous solution was evaluated. The results showed that chalcone exhibited good selective fluorescence quenching effect on Hg(II), with low detection limits and a stoichiometry of 1:1.
JOURNAL OF FLUORESCENCE
(2022)
Article
Chemistry, Physical
Alex Gonzalez-Vergara, Rodrigo Sanchez-Gonzalez, Manuel A. Bravo, Luis F. Aguilar, Luis Espinoza, Marco Mellado
Summary: Chalcone-vanillin 11 exhibits excellent performance as a chemosensor in biochemical analysis, demonstrating high selectivity towards arsenite with a short detection time and low limit of detection and quantification.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Plant Sciences
Claudia Moggia, Manuel A. Bravo, Ricardo Baettig, Marcelo Valdes, Sebastian Romero-Bravo, Mauricio Zuniga, Jorge Cornejo, Fabio Gosetti, Davide Ballabio, Ricardo A. Cabeza, Randolph Beaudry, Gustavo A. Lobos
Summary: Bitter pit is a relevant post-harvest disorder for the apple industry, usually related to calcium deficiency. XRF technology can be used to predict the incidence of bitter pit by analyzing the signal intensity of various mineral elements in the fruit. The study found that, in addition to potassium and calcium, other elements also play a key role in bitter pit prediction.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Spectroscopy
Marco Mellado, Rafaela Sariego-Kluge, Franco Valdes-Navarro, Cesar Gonzalez, Rodrigo Sanchez-Gonzalez, Nancy Pizarro, Joan Villena, Carlos Jara-Gutierrez, Claudio Cordova, Manuel A. Bravo, Luis F. Aguilar
Summary: In this study, 11 new fluorescent pigments were synthesized and their photophysical properties were analyzed. It was found that the chemical structure of the compounds plays a crucial role in determining their properties. The compounds were also applied as fluorescent pigments in living cell imaging, with compound 12a showing potential as an alternative.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Multidisciplinary
Sonnia Parra, Manuel A. Bravo
Summary: This study in the Santiago Metropolitan area of Chile investigated the impact of lockdown measures on air pollutants, showing a significant reduction in concentrations of NO2, NOx, O-3, and PM2.5 due to decreased vehicular traffic.
JOURNAL OF THE CHILEAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Analytical
Albani L. Gonzalez, Valeria A. Lozano, Graciela M. Escandar, Manuel A. Bravo
Article
Chemistry, Analytical
Qian Wu, Li Tian, Xiangyu Shan, Huiling Li, Chao Li, Juan Lu
Summary: A novel ECL sensor was developed by modifying Fe3CuO4-Ru(bpy)3+ and GO-CdS@ZnS on the electrode for the detection of permethrin. The sensor exhibited high sensitivity and a wide detection range.
Article
Chemistry, Analytical
Tingting Gong, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescent biosensing system for high sensitivity detection of MT was established using a new Ag+-stabilized DNA triplex probe (Ag+-SDTP) combined with catalytic hairpin assembly (CHA) and CRISPR/Cas12a signal enhancements. The sensing method is able to selectively detect MT from other non-specific molecules and can achieve low level detection of MT in diluted human serums, demonstrating its potential for monitoring disease-specific MT biomarker at trace levels.
Article
Chemistry, Analytical
Estrella Sanz Rodriguez, Kyra Wood, Paul R. Haddad, Brett Paull
Summary: This study presents a simple, rapid, and reliable method for determining boron in aqueous solutions using suppressed ion chromatography coupled to electrospray ionisation-triple quadrupole mass spectrometry. The method achieved a low limit of detection and demonstrated excellent analytical performance.
Article
Chemistry, Analytical
Aline Cournut, Paul Moustiez, Yannick Coffinier, Christine Enjalbal, Claudia Bich
Summary: Alzheimer's disease is a major cause of senile dementia and is characterized by the aggregation of neurofibrillary tangles and amyloid plaques in the brain. The A beta 1-42 peptide is considered the primary cause of neurotoxicity due to its insolubility and subsequent aggregation. A beta 1-42 and A beta 1-40 have been identified as relevant biomarkers for AD diagnosis, and SurfaceAssisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) was used to monitor the A beta 1-42/A beta 1-40 ratio without prior sample treatment.
Article
Chemistry, Analytical
Dotse Selali Chormey, Buse Tugba Zaman, Tulay Borahan Kustanto, Sezin Erarpat Bodur, Suleyman Bodur, Elif Ozturk Er, Sezgin Bakirdere
Summary: This review provides an overview of the harmful effects of endocrine disrupting chemicals (EDCs) on human health and introduces the methods for analyzing EDCs. Recent research has focused on using green chemicals, such as deep eutectic solvents (DESs), for microextraction to ensure environmental safety.
Article
Chemistry, Analytical
Yan Zhang, Renfeng Xu, Jingjing Wu, Zhenghong Zhang, Yuhuang Wang, Hongqin Yang, Sheng Zhang
Summary: This study visualized the pore-like structures in prostate cancer cell membranes after treatment with the anticancer drug paclitaxel, demonstrating its mechanism of action related to oxidative damage.
Article
Chemistry, Analytical
Chihong Ma, Qin Zhou, Jinjin Shi, Hua Gao, Di Huang, Huimin Xue, Han Wang, Zhenzhong Zhang, Sen Yang, Junli Zhang, Kaixiang Zhang
Summary: We developed a CRISPR-empowered electrochemical biosensor, named PER-E-CRISPR, for amplification-free and sensitive detection of miR-21. The biosensor combines the advantages of CRISPR/Cas13a and primer exchange reaction (PER) for target amplification. Under optimized conditions, the PER-E-CRISPR assay exhibits a linear range from 10-13 to 10-7 M and a limit of detection of 30.2 fM. The biosensor shows excellent performance in actual plasma, indicating promising prospects for miRNA detection in molecular diagnosis.
Article
Chemistry, Analytical
Gang Liang, Jie Zhao, Yufei Gao, Tao Xie, Jianhui Zhen, Ligang Pan, Wenwen Gong
Summary: Molecular docking (MD) analysis is widely used for studying the interaction between aptamers and small molecules. This study established steady-state aptamers of tertiary structures (SATS) using specific aptamers of tetracycline antibiotics as docking models. Molecular docking results revealed multiple binding sites in the SATS of aptamers, with significant variations in binding free energy (BFE) and docking score (DS). The study also proposed a method for MD analysis based on SATS, providing insights into binding mode and predicting binding sites.
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Analytical
Yu Su, Dandan Yang, Yanjie Wang, Jie Ding, Lan Ding, Daqian Song
Summary: In this study, a highly selective molecularly imprinted polymer Cu-MIPs@CS was designed and synthesized for bisphenol A (BPA). Cu-MIPs@CS showed significantly enhanced imprinting factor and selective factor towards BPA compared to MIPs@CS. It also exhibited superior discrimination ability between BPA and its structural analogue. Additionally, Cu-MIPs@CS were successfully applied as a solid phase extraction adsorbent for the determination of BPA in drinking water samples.
Article
Chemistry, Analytical
Yi Qiao, Qiongdan Zhang, Yukun He, Tianguang Cheng, Jing Tu
Summary: Single cell heterogeneity plays an important role in many biological phenomena, and distinguishing cells with specific mutations is beneficial for clinical diagnosis and drug screening. This study introduces a gel plate platform that can distinguish cell types based on their phenotypes, with low equipment requirement. The gel platform has potential in point-of-care circumstances and single-cell stimulation responses that prioritize efficiency and simplicity.
Article
Chemistry, Analytical
Chengke Wang, Shuyang Sun, Ping Wang, Huawei Zhao, Wenling Li
Summary: The food safety of aquatic products is a global concern. Nanotechnology-based analyses have advantages in the detection of bacteria, metal ions, and small molecule contaminants. This review summarizes the recent advances in biosensing strategies for aquatic products and highlights the application of nanomaterials, lateral flow-based biosensors, surface-enhanced Raman scattering, microfluidic chips, and molecular imprinting technologies.
Article
Chemistry, Analytical
Liping Zhu, Zeng Tang, Xuemei Zhang, Li Zhu, Tian Meng, Linying Yu, Ting Xiao, Shasha Lu, Xiaoli Xiong, Xiurong Yang
Summary: A sensitive off-on electrochemiluminescence DNA sensor was developed using Exo III-assisted cascade amplification system. The sensor achieved high selectivity and ultra-high sensitivity in detecting target DNA by utilizing ECL and SPR effects. This study provides a new perspective for designing highly sensitive and programmable ECL biosensors.
Article
Chemistry, Analytical
Tong Li, Mengxu Sun, Suping Xia, Ting Huang, Rong-Tian Li, Chunrong Li, Zong Dai, Jin-Xiang Chen, Jun Chen, Nuan Jia
Summary: Here, we developed a binary system based on DNA tetrahedron and fluorogenic RNA aptamers for highly specific and label-free mRNA imaging in living cells. This system achieved high specificity label-free detection of nucleic acids with a detection limit of 1.34 nM. The method has potential applications in early disease diagnosis and new drug development.
Article
Chemistry, Analytical
Yao Zhao, Shu Zhang, Wang Yao, Yuxuan Zhu, Jing Qian, Juan Yang, Nianjun Yang
Summary: A new hierarchical nanostructured composite with high conductivity and catalytic activity is synthesized. The sensor exhibits significant catalytic effect and high sensitivity for monitoring the environmental endocrine disruptor bisphenol A (BPA).
