Article
Chemistry, Analytical
Mariola Brycht, Slawomira Skrzypek, Valentin Mirceski
Summary: In this study, a simple and easy-to-use method was developed for monitoring the level of FH residues retained on the peel surface of blueberries samples. This method includes the treatment of the BDDE surface and can be used as a rapid screening method for food safety control.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Hemn A. H. Barzani, Hoshyar Saadi Ali, Cihat Sahin, Musa Kiran, Yavuz Yardim
Summary: An effective electrochemical sensor using an unmodified boron-doped diamond electrode was developed for determining genistein by square-wave voltammetry. The cyclic voltammetry study showed irreversible behavior and well-defined oxidation peaks, with pH and supporting electrolytes influencing the oxidation process. The method allowed for quantification of genistein in a linear range of concentrations, with low detection limits. The developed method was successfully applied to detect genistein in model human urine samples.
Article
Materials Science, Multidisciplinary
Shabnam Allahverdiyeva, Pinar Talay Pinar, Yavuz Yardim, Zuhre Senturk
Summary: This study describes the electrochemical investigation and voltammetric determination of the HIV integrase inhibitor dolutegravir for the first time. Results showed that using cathodically pretreated boron-doped diamond electrode, a linear detection of dolutegravir can be achieved under suitable conditions.
DIAMOND AND RELATED MATERIALS
(2021)
Article
Chemistry, Analytical
Shabnam Allahverdiyeva, Yavuz Yardim, Zuhre Senturk
Summary: This study conducted the voltammetric determination of tetracycline antibiotic demeclocycline for the first time, and found that the sensitivity of the method can be enhanced by adding surfactants at different pH values. The developed approach was successfully applied to the quantification of demeclocycline in urine samples.
Article
Biochemistry & Molecular Biology
Magdalena Jakubczyk, Slawomir Michalkiewicz, Agata Skorupa, Kinga Krajcarz
Summary: This article investigates the electrochemical properties of methylisothiazolinone (MIT) and develops a new method for its determination. The method is conducted on a boron-doped diamond electrode and can detect the presence of MIT in household products without the need for separation steps.
Article
Chemistry, Multidisciplinary
Shabnam Allahverdiyeva, Ertugrul Keskin, Ibrahim Yoruk, Yavuz Yardim
Summary: For the first time, a boron-doped diamond electrode was used to determine flavonoid fisetin (FST) quantitatively. Cyclic voltammetric studies showed that the electrochemical oxidation of FST is irreversible and exhibits two well-separated peaks (P-A1 and P-A2) in 0.1 MHNO3 solution. The effects of electrode pretreatment, solution pH, nature of the supporting electrolyte, and instrumental variables on the peak current and potentials of FST were investigated, and the optimal conditions were determined. It was found that the cathodically pre-treated BDD (CPT-BDD) electrode performed better in increasing the FST oxidation signal. Under the optimized conditions and using the SWV technique, the first anodic peak (P-A1) of FST showed a proportional response in a concentration range of 0.5-20.0 mu g mL(-1) (1.7x10(-6)-6.9x10(-5) mol L-1) with a detection limit of 0.08 mu gm L-1 (2.8 x 10(-7) mol L-1). The proposed method was also successfully demonstrated to be applicable in commercial nutritional supplement formulations.
Article
Materials Science, Multidisciplinary
Hoshyar Saadi Ali, Hemn A. H. Barzani, Yavuz Yardim, Zuhre Senturk
Summary: This study presents the first electrochemical investigation of caspofungin using a pretreated boron-doped diamond electrode. By optimizing the experimental conditions, the sensitivity of the voltammetric measurements was improved, allowing for successful determination of caspofungin concentration in commercial dosage formulations.
DIAMOND AND RELATED MATERIALS
(2022)
Article
Chemistry, Analytical
Katarzyna Mielech-Lukasiewicz
Summary: In this study, a boron-doped diamond electrode modified with polypyrrole in the presence of cyclodextrin was used to determine terbinafine. The obtained modified layer was overoxidized and used to develop a sensitive method for terbinafine detection. The relationship between current and terbinafine concentration was studied using square wave voltammetry, demonstrating a linear range for terbinafine determination. The developed protocol showed good accuracy and repeatability for determining terbinafine in pharmaceutical preparations.
ANALYTICAL LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Denise M. Nobrega, Anabel S. Lourenco, David Douglas S. Fernandes, Wellington S. Lyra, Edilene D. T. Moreira, Paulo Henrique G. D. Diniz, Mario C. U. Araujo
Summary: This paper introduces a voltammetric method for determining the coumarin content in guaco leaves, and verifies the reliability of this method. The results show that this method is consistent with high-performance liquid chromatography.
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Analytical
A. T. Ezhil Vilian, Seung-Kyu Hwang, Min Ji Lee, Yun Suk Huh, Young-Kyu Han
Summary: This study demonstrates that Mn-doped ZnS-GCE has excellent electrocatalytic sensing ability for ultralow-level determination of carbendazim (CBZ) in food products. The Mn-doped ZnS-GCE exhibits a larger linear working range and a lower detection limit for CBZ, and can be used for the precise identification of spiked CBZ in lemon wash water samples, tomato sauce, and orange juice samples.
MICROCHEMICAL JOURNAL
(2022)
Article
Materials Science, Multidisciplinary
Sourav Sain, Mateusz Ficek, Adrian Olejnik, Miroslaw Sawczak, Robert Bogdanowicz, Susanta Sinha Roy
Summary: This study investigates the performance of boron-doped carbon nanowalls (B:CNW) and boron-doped diamond (BDD) materials in the electrochemical detection of the highly toxic herbicide paraquat (PQ). It reveals that B:CNWs have higher sensitivity and lower limit of detection (LOD) compared to BDD. Density functional theory calculations support a proposed two-step detection mechanism.
DIAMOND AND RELATED MATERIALS
(2023)
Article
Chemistry, Analytical
Shabnam Allahverdiyeva, Oruc Yunusoglu, Yavuz Yardim, Zuhre Senturk
Summary: This study presents the electrochemical activity of favipiravir and its application in electroanalytical sensing. The use of the cationic surfactant, CTAB, was shown to enhance the accumulation of favipiravir at the electrode surface, enabling its adsorptive stripping voltammetric determination. The methodology developed demonstrated feasibility for analysis of commercial tablet formulations and model human urine samples.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Analytical
Renata Selesovska, Romana Sokolova, Kateroina Krejcova, Karolina Schwarzova-Peckova, Tomas Mikysek, Oleksandr Matvieiev
Summary: The first study on the electrochemical oxidation of triazole fungicide tebuconazole was conducted using an oxygen-terminated boron-doped diamond electrode. The research explored the irreversible anodic process occurring at +1.75 V (vs Ag/AgCl/KCl(sat.)) in 0.1 mol/L HNO3 through various techniques such as cyclic voltammetry, IR spectroelectrochemistry, and density functional theory calculations. The study provided insights into the oxidation mechanisms, revealing the formation of hydroxylated and dihydroxylated derivatives as well as an o-quinone derivative.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2023)
Article
Electrochemistry
Olha Dushna, Liliya Dubenska, Marian Vojs, Marian Marton, Igor Patsay, Sophia Ivakh, Serhiy Plotycya
Summary: In this paper, a planar electrochemical cell with a novel screen-printed sensor and a boron-doped diamond electrode was used for the first time to determine the alkaloid atropine. By changing the diameter of the electrode, the linear concentration range was improved. Calibration curves were obtained using differential pulse voltammetry and square-wave voltammetry. The method can also be used for determination in drugs and biological fluids, and has the advantages of being rapid, inexpensive, and portable.
ELECTROCHIMICA ACTA
(2022)
Article
Chemistry, Medicinal
Iulia Rus, Alexandra Pusta, Mihaela Tertis, Cristina Barbalata, Ioan Tomuta, Robert Sandulescu, Cecilia Cristea
Summary: A simple, fast and direct electrochemical method using a boron-doped diamond electrode for gemcitabine detection was reported in this study. The influence of pH and supporting electrolytes were tested, with the optimized differential pulse voltammetry method having a linear range of 2.5-50 μg/mL and a detection limit of 0.85 μg/mL. An amperometric method was also optimized, with a linear range of 0.5-65 μg/mL and a detection limit of 0.15 μg/mL in phosphate-buffered saline of pH 7.4 and pH 5.5.
Article
Chemistry, Analytical
Romana Jarosova, Kallyni Irikura, Romeu C. Rocha-Filho, Greg M. Swain
Summary: This study reports on the analytical performance of boron-doped diamond thin-film electrodes for detecting the virulence factor pyocyanin. The results demonstrate that diamond electrodes can sensitively and reproducibly detect pyocyanin under specific conditions, without the need for conventional pretreatment methods.
Article
Chemistry, Analytical
Anderson M. Santos, Ademar Wong, Maria H. A. Feitosa, Lais P. Silva, Orlando Fatibello-Filho, Fernando C. Moraes
Summary: This study reports the development of a new carbon paste electrode modified with graphene and nanodiamond for the determination of nimesulide in biological and environmental samples. The electrochemical sensor showed improved analytical signal and the oxidation of nimesulide occurred at a specific potential. The proposed method successfully measured nimesulide in real samples with good recovery rates.
Article
Materials Science, Multidisciplinary
Karina M. Zaniolo, Sonia R. Biaggio, Joni A. Cirelli, Mariana A. Cominotte, Nerilso Bocchi, Romeu C. Rocha-Filho
Summary: Titanium and its alloys are widely used biomaterials in dental and orthopedic implant applications. Researchers have proposed a method to produce a TiO2 coating on titanium through micro-arc oxidation in a green electrolyte. The modified Ti surface exhibited enhanced bioactivity and improved performance in biological tests.
MATERIALS RESEARCH EXPRESS
(2022)
Article
Chemistry, Physical
Joao Pedro Silva, Kallyni Irikura, Sonia R. Biaggio, Nerilso Bocchi, Romeu C. Rocha-Filho
Summary: A rapid and facile microwave-assisted method coupled with mild mechanical treatment was used to obtain Mn3O4 with good properties as a supercapacitor material. Mn3O4 was synthesized through thermal decomposition of epsilon-MnO2 using microwave irradiation. The resulting Mn3O4 had a single phase structure after only 5 minutes of microwave heating. A mild mechanical treatment further increased the particle size and specific surface area of Mn3O4. Electrochemical tests showed that the Mn3O4 electrodes had good pseudocapacitive behavior and electrochemical stability.
Article
Chemistry, Physical
Daiane Piva B. Silva, Juliana Bruneli Falqueto, Nerilso Bocchi, Sonia R. Biaggio, Romeu C. Rocha-Filho
Summary: A new route for the synthesis of highly pure true nanoparticles of LiMn2O4 through microwave-assisted hydrothermal reaction using water-soluble reagents at low temperature and short reaction time is presented. The synthesized nanoparticles showed excellent chemical, structural, and promising electrochemical properties.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Article
Chemistry, Analytical
Tiago Almeida Silva, Bruna Claudia Lourencao, Alexsandra Dias da Silva, Orlando Fatibello-Filho
Summary: In this work, the versatility of chitosan biopolymer was explored for the sustainable manufacture of novel electrochemical sensors based on carbon black and chitosan-stabilized platinum nanoparticles. Highly stabilized platinum nanoparticles were synthesized at room temperature and characterized. The electrochemical sensors showed excellent performance in the determination of hydrogen peroxide and bisphenol A with high sensitivity and accuracy.
ANALYTICAL METHODS
(2023)
Article
Chemistry, Physical
Isaac Sanchez-Montes, Jussara Carneiro Doerenkamp, Yeison Nunez-de la Rosa, Peter Hammer, Romeu C. Rocha-Filho, Jose M. Aquino
Summary: Proper treatment of water and wastewater is currently a major concern, and this study aims to synthesize, characterize, and use functionally modified graphitic carbon nitride to assess its performance in the oxidation of the herbicide tebuthiuron. The results show that complete oxidation of tebuthiuron is achieved under acidic conditions using hydrogen peroxide as the oxidant, producing carboxylic acids and nitrate ions as the main products.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
Ricardo F. Brocenschi, Kallyni Irikura, Naihara Wachter, Greg M. Swain, Romeu C. Rocha-Filho
Summary: This study reports on the electropolishing of boron-doped diamond (BDD) electrodes in the presence of acetic and sulfuric acid. The electropolishing treatment resulted in a smoother diamond surface with reduced non-diamond carbon impurity content and increased surface oxygen content. The combination of electropolishing and cathodic pretreatment further decreased the surface oxygen content and improved the electrochemical reversibility and electron-transfer kinetics of the BDD electrodes. Electropolished BDD electrodes also exhibited a higher oxidation peak potential for ascorbic acid compared to as-received BDD electrodes, indicating a decrease in surface carbon-oxygen functional groups.
DIAMOND AND RELATED MATERIALS
(2023)
Article
Chemistry, Analytical
Thatyara Oliveira Monteiro, Antonio Gomes dos Santos Neto, Alan Silva de Menezes, Flavio Santos Damos, Rita de Cassia Silva Luz, Orlando Fatibello-Filho
Summary: A sensitive and selective label-free photoelectrochemical immunosensor was developed for the detection of cardiac troponin I. The immunosensor utilized a Bi2S3/BiVO4/FTO platform, which showed enhanced photocurrent compared to a platform without Bi2S3. The immobilization of cTnI antibodies on the platform inhibited the photocurrent in the presence of cTnI, and the resulting photocurrent showed a linear relationship with the logarithm of cTnI concentration.
Article
Chemistry, Analytical
Ademar Wong, Anderson M. M. Santos, Maria H. A. Feitosa, Orlando Fatibello-Filho, Fernando C. C. Moraes, Maria D. P. T. Sotomayor
Summary: The study developed a flow injection analysis (FIA) system using a cathodically pretreated boron-doped diamond electrode (CPT-BDD) and multiple-pulse amperometry (MPA) for simultaneous determination of uric acid (UA) and caffeine (CAF). The proposed method showed good repeatability and stability, and no interference from various substances was observed. The BDD sensor exhibited superior analytical performance compared to other sensors reported in the literature.
Article
Chemistry, Multidisciplinary
Karina M. Zaniolo, Sonia R. Biaggio, Joni A. Cirelli, Mariana A. Cominotte, Nerilso Bocchi, Romeu C. Rocha-Filho, Clovis W. O. de Souza
Summary: Silver nanoparticles (AgNp) were deposited on porous TiO2 surfaces to provide antimicrobial activity, and the surfaces were coated with bioresorbable polymer for controlled release of silver ions while maintaining biocompatibility. The AgNp-containing surfaces showed antimicrobial activity against Staphylococcus aureus, with better results for surfaces without the polymer coating. However, all surfaces exhibited good biocompatibility and the polymer-coated surfaces promoted greater cell differentiation. The electrospun polymer fibers allowed controlled release of silver ions in a phosphate-buffered saline (PBS) medium.
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Ingrid Silva, Pedro Nascimento, Rochel Lago, Mozart Ramos, Fernando Galembeck, Romeu Rocha Filho, Ana Paula Teixeira
Summary: This article describes the formulation process of the "2022 Chemistry Post Movement - Sustainability and Sovereignty" action plan launched by the Brazilian Chemical Society, which aims to promote chemistry's contribution to the sustainable development and sovereignty of Brazil through various activities. The action plan is based on two broad Chemistry Sustainable Development Goals and will be implemented through different actions.
Article
Chemistry, Analytical
Rebeca M. S. Silva, Anderson M. Santos, Ademar Wong, Orlando Fatibello-Filho, Fernando C. Moraes, Marco A. S. Farias
Summary: A new electrode based on functionalized graphene and gold nanoparticles dispersed in a chitosan film was prepared for the determination of ofloxacin. The characterization of the electrode showed improved analytical signal, electrochemical activity, and electron transfer rate. The proposed sensor, determined by square-wave voltammetry, had a linear concentration range of 0.10-4.9 μmol L-1, demonstrating its successful application in pharmaceutical formulations, synthetic urine, and water river samples.
ANALYTICAL METHODS
(2022)
Article
Materials Science, Multidisciplinary
Anderson M. Santos, Ademar Wong, Orlando Fatibello-Filho, Fernando C. Moraes
Summary: This study reports the development and application of an amperometric biosensor based on carbon paste electrode modified with laccase enzyme, glutaraldehyde, and gold nanoparticles for the determination of dopamine. The materials were characterized morphologically and chemically. Optimization studies were performed to determine the optimal amount of enzyme and pH level. The biosensor showed a linear concentration range and detection limit when applied with the amperometric technique.
C-JOURNAL OF CARBON RESEARCH
(2022)
Article
Chemistry, Analytical
Karen Kenlderi de Lima Augusto, Gabriela Rizzo Piton, Paulo Cardoso Gomes-Junior, Gustavo Patelli Longatto, Fernando Cruz de Moraes, Orlando Fatibello-Filho
Summary: This study synthesized hydrophobic deep eutectic solvents (HDES) using fatty acids and tetrabutylammonium bromide (TBAB) or 1-octanol, and analyzed their physicochemical properties. A carbon paste electrode modified with decanoic acid and TBAB-based HDES showed enhanced electrochemical activity, fast electron transfer rate, and high surface area, resulting in increased oxidation peak currents and decreased peak potential separation. The electrochemical determination of hydroquinone (H(2)Q) using square-wave adsorptive anodic stripping voltammetry (SWAdASV) was also successfully carried out, with a low limit of detection (LOD). The method was applied to the determination of H(2)Q in dermatological creams.
ANALYTICAL METHODS
(2022)
Article
Chemistry, Analytical
Qian Wu, Li Tian, Xiangyu Shan, Huiling Li, Chao Li, Juan Lu
Summary: A novel ECL sensor was developed by modifying Fe3CuO4-Ru(bpy)3+ and GO-CdS@ZnS on the electrode for the detection of permethrin. The sensor exhibited high sensitivity and a wide detection range.
Article
Chemistry, Analytical
Tingting Gong, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescent biosensing system for high sensitivity detection of MT was established using a new Ag+-stabilized DNA triplex probe (Ag+-SDTP) combined with catalytic hairpin assembly (CHA) and CRISPR/Cas12a signal enhancements. The sensing method is able to selectively detect MT from other non-specific molecules and can achieve low level detection of MT in diluted human serums, demonstrating its potential for monitoring disease-specific MT biomarker at trace levels.
Article
Chemistry, Analytical
Estrella Sanz Rodriguez, Kyra Wood, Paul R. Haddad, Brett Paull
Summary: This study presents a simple, rapid, and reliable method for determining boron in aqueous solutions using suppressed ion chromatography coupled to electrospray ionisation-triple quadrupole mass spectrometry. The method achieved a low limit of detection and demonstrated excellent analytical performance.
Article
Chemistry, Analytical
Aline Cournut, Paul Moustiez, Yannick Coffinier, Christine Enjalbal, Claudia Bich
Summary: Alzheimer's disease is a major cause of senile dementia and is characterized by the aggregation of neurofibrillary tangles and amyloid plaques in the brain. The A beta 1-42 peptide is considered the primary cause of neurotoxicity due to its insolubility and subsequent aggregation. A beta 1-42 and A beta 1-40 have been identified as relevant biomarkers for AD diagnosis, and SurfaceAssisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) was used to monitor the A beta 1-42/A beta 1-40 ratio without prior sample treatment.
Article
Chemistry, Analytical
Dotse Selali Chormey, Buse Tugba Zaman, Tulay Borahan Kustanto, Sezin Erarpat Bodur, Suleyman Bodur, Elif Ozturk Er, Sezgin Bakirdere
Summary: This review provides an overview of the harmful effects of endocrine disrupting chemicals (EDCs) on human health and introduces the methods for analyzing EDCs. Recent research has focused on using green chemicals, such as deep eutectic solvents (DESs), for microextraction to ensure environmental safety.
Article
Chemistry, Analytical
Yan Zhang, Renfeng Xu, Jingjing Wu, Zhenghong Zhang, Yuhuang Wang, Hongqin Yang, Sheng Zhang
Summary: This study visualized the pore-like structures in prostate cancer cell membranes after treatment with the anticancer drug paclitaxel, demonstrating its mechanism of action related to oxidative damage.
Article
Chemistry, Analytical
Chihong Ma, Qin Zhou, Jinjin Shi, Hua Gao, Di Huang, Huimin Xue, Han Wang, Zhenzhong Zhang, Sen Yang, Junli Zhang, Kaixiang Zhang
Summary: We developed a CRISPR-empowered electrochemical biosensor, named PER-E-CRISPR, for amplification-free and sensitive detection of miR-21. The biosensor combines the advantages of CRISPR/Cas13a and primer exchange reaction (PER) for target amplification. Under optimized conditions, the PER-E-CRISPR assay exhibits a linear range from 10-13 to 10-7 M and a limit of detection of 30.2 fM. The biosensor shows excellent performance in actual plasma, indicating promising prospects for miRNA detection in molecular diagnosis.
Article
Chemistry, Analytical
Gang Liang, Jie Zhao, Yufei Gao, Tao Xie, Jianhui Zhen, Ligang Pan, Wenwen Gong
Summary: Molecular docking (MD) analysis is widely used for studying the interaction between aptamers and small molecules. This study established steady-state aptamers of tertiary structures (SATS) using specific aptamers of tetracycline antibiotics as docking models. Molecular docking results revealed multiple binding sites in the SATS of aptamers, with significant variations in binding free energy (BFE) and docking score (DS). The study also proposed a method for MD analysis based on SATS, providing insights into binding mode and predicting binding sites.
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Analytical
Yu Su, Dandan Yang, Yanjie Wang, Jie Ding, Lan Ding, Daqian Song
Summary: In this study, a highly selective molecularly imprinted polymer Cu-MIPs@CS was designed and synthesized for bisphenol A (BPA). Cu-MIPs@CS showed significantly enhanced imprinting factor and selective factor towards BPA compared to MIPs@CS. It also exhibited superior discrimination ability between BPA and its structural analogue. Additionally, Cu-MIPs@CS were successfully applied as a solid phase extraction adsorbent for the determination of BPA in drinking water samples.
Article
Chemistry, Analytical
Yi Qiao, Qiongdan Zhang, Yukun He, Tianguang Cheng, Jing Tu
Summary: Single cell heterogeneity plays an important role in many biological phenomena, and distinguishing cells with specific mutations is beneficial for clinical diagnosis and drug screening. This study introduces a gel plate platform that can distinguish cell types based on their phenotypes, with low equipment requirement. The gel platform has potential in point-of-care circumstances and single-cell stimulation responses that prioritize efficiency and simplicity.
Article
Chemistry, Analytical
Chengke Wang, Shuyang Sun, Ping Wang, Huawei Zhao, Wenling Li
Summary: The food safety of aquatic products is a global concern. Nanotechnology-based analyses have advantages in the detection of bacteria, metal ions, and small molecule contaminants. This review summarizes the recent advances in biosensing strategies for aquatic products and highlights the application of nanomaterials, lateral flow-based biosensors, surface-enhanced Raman scattering, microfluidic chips, and molecular imprinting technologies.
Article
Chemistry, Analytical
Liping Zhu, Zeng Tang, Xuemei Zhang, Li Zhu, Tian Meng, Linying Yu, Ting Xiao, Shasha Lu, Xiaoli Xiong, Xiurong Yang
Summary: A sensitive off-on electrochemiluminescence DNA sensor was developed using Exo III-assisted cascade amplification system. The sensor achieved high selectivity and ultra-high sensitivity in detecting target DNA by utilizing ECL and SPR effects. This study provides a new perspective for designing highly sensitive and programmable ECL biosensors.
Article
Chemistry, Analytical
Tong Li, Mengxu Sun, Suping Xia, Ting Huang, Rong-Tian Li, Chunrong Li, Zong Dai, Jin-Xiang Chen, Jun Chen, Nuan Jia
Summary: Here, we developed a binary system based on DNA tetrahedron and fluorogenic RNA aptamers for highly specific and label-free mRNA imaging in living cells. This system achieved high specificity label-free detection of nucleic acids with a detection limit of 1.34 nM. The method has potential applications in early disease diagnosis and new drug development.
Article
Chemistry, Analytical
Yao Zhao, Shu Zhang, Wang Yao, Yuxuan Zhu, Jing Qian, Juan Yang, Nianjun Yang
Summary: A new hierarchical nanostructured composite with high conductivity and catalytic activity is synthesized. The sensor exhibits significant catalytic effect and high sensitivity for monitoring the environmental endocrine disruptor bisphenol A (BPA).
