Interleukin-1β gene is not associated with preeclampsia in Taiwanese

Objective: To identify associations between the interleukin-1 beta gene and preeclampsia in Taiwanese women. Methods and Materials: We genotyped Taiwanese population (102 women with preeclampsia and 148 controls) for two polymorphisms of the interleukin-1 beta gene (promoter region and Exon 5) by using polymerase chain reaction and restriction fragment length polymorphism analysis. The association between the genotype and disease was examined by Chi-square tests. Results: We found no association between the two polymorphic sites of interleukin-1 beta gene and preeclampsia. No significant differences were detected in genotype distributions and allele frequencies of the Aval polymorphism at position -511 in the promoter region and the TaqI polymorphism at position +3953 within Exon 5. Conclusion: Our data do not support a role of the interleukin-1 beta gene in the pathogenesis of preeclampsia in Taiwanese women. Copyright (C) 2012, Taiwan Association of Obstetrics & Gynecology. Published by Elsevier Taiwan LLC. All rights reserved.