Article
Environmental Sciences
Lei Ge, Yu-Qing Gao, Zhe Han, Shu-Jun Liu, Xing-Yue Wang, Xiao-Jie Zhang, Rui-Hao Tang, Rui-Feng Zhang, Dui Sun, Bo Feng, De-Jian Zhang, Cheng-Guang Liang
Summary: This study demonstrates that Olaquindox (OLA) intake has detrimental effects on sperm quality and offspring survival in male mice. High-dose OLA administration leads to changes in body weight, organ weights, and the morphology of the testis seminiferous tubules. It also reduces sperm count, motility, and viability. Both low and high doses of OLA induce oxidative damage, early apoptosis, and abnormal mitochondrial membrane potential in sperm. While high-dose OLA impairs the development of in vitro fertilized embryos, it does not affect the natural fertility of males, although paternal OLA intake significantly decreases offspring survival rate from the age of 4 weeks.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Zi Teng, YaNan Liu, ZeLin Wang, YuSheng Zhang, MeiNa Xie, Peng Zhu, Ning Li, FuJun Liu, XueXia Liu
Summary: Bisphenol A (BPA) exposure negatively affects male fertility, while melatonin (MLT) treatment can alleviate these effects by regulating antioxidant molecules, inhibiting germ cell apoptosis, and maintaining male fertility. This study provides more insights into the molecular mechanisms of BPA and MLT in male reproduction.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Zi-jian Xu, Meng Liu, Qin-Jian Niu, Yu-Xuan Huang, Ling Zhao, Xin Gen Lei, Lv-Hui Sun
Summary: In this study, the molecular biology of Se deficiency or excess in spermatogenesis in mice was explored. The results showed that Se deficiency reduced body weight and sperm density, and increased sperm deformity, while Se excess decreased sperm density and motility. Both Se deficiency and excess induced testicular damage and activated PI3K/AKT-mediated apoptosis and cell proliferation signaling.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Amany E. Nofal, Yosry A. Okdah, Mohamed I. Rady, Hamada Z. Hassaan
Summary: This study aimed to investigate the potential benefits of Gum Arabic/Acacia senegal in mitigating the harmful effects of cisplatin on spermatogenesis and testicular health in male adult rats. The results showed that cisplatin caused oxidative stress, decreased antioxidant activities, and histological damage to the testicular structure. However, co-administration of Gum Arabic with cisplatin reversed these effects and improved sperm quality and testicular health.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Obstetrics & Gynecology
Bircan Kolbasi, Muhammet Volkan Bulbul, Seda Karabulut, Ceren Erdem Altun, Cagri Cakici, Gozde Ulfer, Tangul Mudok, Ilknur Keskin
Summary: In this study, chronic stress was found to disrupt the integrity of the blood-testis barrier (BTB) and impair sperm parameters in mice. Decreased expression levels of ZO-1 and CLDN11 may be the causative factor for these effects.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Cell Biology
Marcela Nascimento Sertorio, Helena Cesar, Esther Alves de Souza, Lais Vales Mennitti, Aline Boveto Santamarina, Leonardo Mendes De Souza Mesquita, Andrea Juca, Breno Picin Casagrande, Debora Estadella, Odair Aguiar Jr, Luciana Pellegrini Pisani
Summary: Parental nutrition can have a significant impact on the health and reproductive development of future generations. Maternal and paternal intake of high-fat diets can adversely affect male reproductive health, leading to hormonal imbalances, oxidative stress, and changes in sperm quality. In this study, epigenetic markers, inflammatory response, and oxidative balance were evaluated in the testes and epididymis of adult offspring. The results showed that the maternal diet had a significant effect on testicular epigenetic parameters, inflammation, and daily sperm production, while the paternal diet influenced serum testosterone levels. The combined intake of a high-fat high-sugar diet by both parents exacerbated the decrease in daily sperm production. These findings highlight the importance of parental nutrition in programming the reproductive health of male offspring.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Nutrition & Dietetics
Md Mustahsan Billah, Saroj Khatiwada, Virginie Lecomte, Margaret J. Morris, Christopher A. Maloney
Summary: This study investigated the effects of an antioxidant-based micronutrient supplement on sperm and testicular oxidative damage in male rats fed a high-fat diet. The results suggest that the supplement may reduce oxidative damage in sperm and testis and improve testicular antioxidant capacity.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Biochemical Research Methods
Mohamed A. Al-Griw, Suliman M. Shalabi, Rabia O. Alghazeer, Abdul H. Elnfati, Soad A. Treesh, Ahmeda E. Benjama, Ghalia Shamlan, Mahmmoud M. Habibullah, Areej A. Eskandrani, Afnan M. Alnajeebi, Nouf A. Babteen, Wafa S. Alansari
Summary: This study explored the therapeutic potential of Nigella sativa (NS) seed extract on testis and sperm abnormalities in BPA-exposed mice and characterized the underlying mechanism. The results demonstrate that NS oil protects mice against BPA-induced sperm and testis abnormalities, likely by suppressing levels of the oxidative stress marker, MDA, and enhancing the levels of the antioxidant marker, GSH.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2023)
Article
Food Science & Technology
Hyeon-Hwa Nam, Sohi Kang, Yun-Soo Seo, Jun Lee, Byeong Cheol Moon, Hae June Lee, Ji Hye Lee, Bohye Kim, Sueun Lee, Joong-Sun Kim
Summary: The larvae extract of Protaetia brevitorsis seulensis protects against radiation-induced testicular injury through its antioxidative properties. This suggests its potential clinical applicability as a neoadjuvant therapy for preventing testicular damage caused by cancer radiotherapy.
FOOD SCIENCE & NUTRITION
(2022)
Article
Multidisciplinary Sciences
Edidiong Nnamso Akang, Chinyerum Sylvia Opuwari, Swesme Enyioma-Alozie, Lionel Wildy Moungala, Tamarapreye Emmanuel Amatu, Ibrahim Wada, Rose Ogeyi Ogbeche, Oluwatoyin Omolayo Ajayi, Mojisola Modupe Aderonmu, Olaitan Boluwatife Shote, Lateef Adekunle Akinola, Oladapo Adenrele Ashiru, Ralf Henkel
Summary: A study on semen parameters in Nigeria and South Africa between 2010 and 2019 reveals a significant decline in sperm quality, highlighting the increasing male infertility problem in these regions.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Chuckles Ch. Marak, Guruswami Gurusubramanian, Vikas Kumar Roy
Summary: Cycas pectinata seeds have been traditionally used as a food source and for improving male sexual potency. A study examined the effect of Cycas pectinata seed extract (CPE) on testicular activity in mice. The results showed that CPE significantly increased sperm parameters, antioxidant status, and germ cell proliferation.
PROCESS BIOCHEMISTRY
(2023)
Article
Andrology
Hissah Ahmed Alturki, Hany Amin Elsawy, Ademola Clement Famurewa
Summary: This study investigated the effect of silymarin (SIL) on testicular toxicity induced by acrylamide (ACR) in rats. The results showed that SIL could attenuate ACR-induced reproductive deficits, restore antioxidant balance, and maintain DNA integrity.
Article
Reproductive Biology
Tong He, Huanping Guo, Xipeng Shen, Xiao Wu, Lin Xia, Xuelin Jiang, Yinying Xu, Dan Chen, Yunfang Zhang, Dongmei Tan, Yi Tan
Summary: Using high-throughput LC-MS/MS, our study revealed an altered signature of RNA modifications in the mouse testis and sperm under a hypoxia model. These data may be strongly related to human conditions in a similar hypoxia environment.
BIOLOGY OF REPRODUCTION
(2021)
Article
Reproductive Biology
Kaveh Khazaeel, Sameerah Abdul Zahra Daaj, Abbas Sadeghi, Mohammad Reza Tabandeh, Zahra Basir
Summary: Quercetin has a protective role in testicular toxicity induced by crude oil vapor, improving sperm parameters, antioxidant enzyme activities, histological indexes, and apoptotic gene expression. This suggests that quercetin has the potential to reduce the side effects of crude oil vapor on the male reproductive system.
REPRODUCTIVE TOXICOLOGY
(2022)
Article
Andrology
Arcangelo Barbonetti, Daniele Tienforti, Chiara Castellini, Francesca Di Giulio, Mario Muselli, Alessandro Pizzocaro, Walter Vena, Marco Giorgio Baroni, Rosario Pivonello, Andrea M. Isidori, Mario Maggi, Giovanni Corona
Summary: A network meta-analysis was conducted to evaluate the effects of antioxidants on idiopathic oligo-astheno-teratozoospermia. The results showed that l-carnitine combined with l-acetyl-carnitine had the best improvement in sperm concentration, motility, and morphology. Folate was effective in improving sperm concentration. Vitamin E+selenium or zinc had the highest improvement in total motility. Pentoxifylline and vitamin E+CoQ10 contributed to progressive motility.
Article
Pharmacology & Pharmacy
Feng Zhang, Suying Dang, Runzhe Shu, Yougui Xiang, Ying Kuang, Jian Fei, Zhugang Wang
INTERNATIONAL JOURNAL OF TOXICOLOGY
(2015)
Article
Cell Biology
R. Shu, W. Wong, Q. H. Ma, Z. Z. Yang, H. Zhu, F. J. Liu, P. Wang, J. Ma, S. Yan, J. M. Polo, C. C. A. Bernard, L. W. Stanton, G. S. Dawe, Z. C. Xiao
CELL DEATH & DISEASE
(2015)
Article
Neurosciences
Jing Lu, Runzhe Shu, Yan Zhu
JOURNAL OF ALZHEIMERS DISEASE
(2018)
Article
Cell Biology
Huaqiang Yang, Guohao Wang, Haitao Sun, Runzhe Shu, Tao Liu, Chuan-En Wang, Zhaoming Liu, Yu Zhao, Bentian Zhao, Zhen Ouyang, Dongshan Yang, Jiao Huang, Yueling Zhou, Shihua Li, Xiaodan Jiang, Zhicheng Xiao, Xiao-Jiang Li, Liangxue Lai
Article
Multidisciplinary Sciences
Run-Zhe Shu, Feng Zhang, Xue-Song Liu, Chun-Liang Li, Long Wang, Yi-Lin Tai, Xiao-Lin Wu, Xue Yang, Xiao-Dong Liao, Ying Jin, Ming-Min Gu, Lei Huang, Xiao-Fen Pang, Zhu-Gang Wang
Article
Andrology
Yu-Ling Zhang, Feng-Jun Liu, Xiao-Li Chen, Zi-Qiang Zhang, Run-Zhe Shu, Xue-Li Yu, Xiao-Wei Zhai, Li-Jun Jin, Xue-Gang Ma, Qiao Qi, Zhi-Jie Liu
SYSTEMS BIOLOGY IN REPRODUCTIVE MEDICINE
(2013)
Article
Toxicology
Feng Zhang, Runzhe Shu, Xiaolin Wu, Xiaoping Zhao, Dechun Feng, Long Wang, Shunyuan Lu, Qiaoling Liu, Yougui Xiang, Jian Fei, Lei Huang, Zhugang Wang
TOXICOLOGY LETTERS
(2009)
Article
Oncology
Runzhe Shu, Vera J. Evtimov, Maree V. Hammett, Nhu-Y N. Nguyen, Junli Zhuang, Peter J. Hudson, Maureen C. Howard, Aleta Pupovac, Alan O. Trounson, Richard L. Boyd
Summary: The study developed dual CAR-T cells targeting multiple tumor antigens to improve the effectiveness of CAR immunotherapies. Special design of CD47CAR and monomerization process can reduce damage to normal tissue.
MOLECULAR THERAPY-ONCOLYTICS
(2021)
Review
Cell Biology
Rasa Islam, Aleta Pupovac, Vera Evtimov, Nicholas Boyd, Runzhe Shu, Richard Boyd, Alan Trounson
Summary: Natural killer (NK) cells play a crucial role in cancer treatment due to their potent ability to target cancer cells. Strategies to enhance NK cell efficacy include using cytokines, synthetic compounds, genetic modifications, and targeting immune checkpoints. Further research and development are needed to optimize NK cell-based immunotherapies.
Meeting Abstract
Cell & Tissue Engineering
N. R. Boyd, M. Tiedemann, K. Cartledge, M. Cao, V. Evtimov, R. Shu, T. Nguyen, N. Nguyen, I. Nisbet, R. Boyd, A. Trounson
Meeting Abstract
Immunology
N. Payne, R. Shu, G. Sun, A. Sylvain, Z. Zhang, R. Morey, L. Laurent, D. Yu, C. Bernard
EUROPEAN JOURNAL OF IMMUNOLOGY
(2016)
Article
Hematology
Xue-Song Liu, Xi-Hua Li, Yi Wang, Run-Zhe Shu, Long Wang, Shun-Yuan Lu, Hui Kong, Yue-E Jin, Li-Jun Zhang, Jian Fei, Sai-Juan Chen, Zhu Chen, Ming-Min Gu, Zhen-Yu Lu, Zhu-Gang Wang
Article
Biochemistry & Molecular Biology
Zhi-Qiang Wang, Shao-Hua Tian, Yao-Zhou Shi, Ping-Tong Zhou, Zhen-Yi Wang, Run-Zhe Shu, Landian Hu, Xiangyin Kong
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2007)
