Review
Chemistry, Analytical
Xu Teng, Ling Qi, Tao Liu, Linhai Li, Chao Lu
Summary: This review summarizes the applications of nanomaterial-based chemiluminescence biosensors for tracing reactive oxygen species (ROS) in recent years. The selection of nanomaterials and the basic mechanism for selective detection of ROS were focused on. Thinking and predictions on exploring novel nanomaterial-based CL platforms were provided. This review may inspire new strategies for ROS tracing in biological environments. (c) 2023 Elsevier B.V. All rights reserved.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Jianing Niu, Qiurong Chang, Junting Xu, Jinli Li, Wenqiang Liu, Zhiqin Chen, Xianting Jiao, Yi Guo, Xiaoming Teng
Summary: This study aimed to identify the optimal oxidation-reduction level in the fertilization medium for IVF outcomes using the MiOXSYS system. It found that sORP values within the range of 228.7-235.3 mV were associated with better pregnancy outcomes and embryo quality.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Chuanlin Huang, Wenjuan Zhou, Riliga Wu, Weijiang Guan, Nengsheng Ye
Summary: This review summarizes the roles of nanomaterials in chemiluminescence (CL) systems, mainly including their roles as catalysts, emitters, and carriers. It also reviews the nanomaterial-based CL probes for biosensing and bioimaging of reactive oxygen species (ROS) developed in the past five years. The review is expected to provide guidance for the design and development of nanomaterial-based CL probes and facilitate the wider application of CL analysis in ROS sensing and imaging in biological systems.
Article
Health Care Sciences & Services
Ioana Zaha, Petronela Naghi, Liana Stefan, Cosmina Bunescu, Mihaela Radu, Mariana Eugenia Muresan, Mircea Sandor, Liliana Sachelarie, Anca Huniadi
Summary: The microfluidic sperm selection method was found to improve the outcomes of in vitro fertilization (IVF) procedures. This method, which selects spermatozoa with the lowest DNA fragmentation rate, resulted in higher blastocyst rates and clinical pregnancy rates. It has the potential to be widely used in intracytoplasmic sperm injection (ICSI) and improve the workflow of standard IVF, reducing intervention by laboratory personnel and providing more consistent incubation conditions.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Obstetrics & Gynecology
Rivka Koedooder, Delshad M. Maghdid, Nicole G. M. Beckers, Sam Schoenmakers, Dik J. Kok, Joop S. E. Laven
Summary: The research showed that clinical pregnancy results in significant changes in the urinary microbiota, and the composition of the microbiome before IVF/IVF-ICSI treatment can potentially be used as a predictor of clinical pregnancy.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Nutrition & Dietetics
Xinrui Yao, Sitong Dong, Wenzheng Guan, Lingjie Fu, Gaoyu Li, Zhen Wang, Jiao Jiao, Xiuxia Wang
Summary: The study investigates the association between gut microbiota-derived short chain fatty acids (SCFAs) and clinical pregnancy outcomes in females undergoing IVF/ICSI-ET. Fecal propionate levels were significantly higher in females with no pregnancies compared to those with clinical pregnancies. Fecal propionate was found to be an independent risk factor for no pregnancies, and its high concentration was negatively associated with clinical pregnancy outcomes.
Article
Endocrinology & Metabolism
Zhaoyang Shen, Xiaoyan Luo, Jianming Xu, Yuqing Jiang, Wenhui Chen, Qingling Yang, Yingpu Sun
Summary: This study investigated the effects of progesterone elevation on triggering day on the clinical pregnancy rate (CPR) of IVF/ICSI cycles in patients with different BMI. The results showed that women with higher BMI had lower progesterone levels on triggering day and a decreased CPR. Additionally, progesterone elevation on hCG day was associated with decreased CPRs regardless of women's BMI level.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Sofia Makieva, Celine Staehli, Min Xie, Ana Velasco Gil, Maike Katja Sachs, Brigitte Leeners
Summary: This study aimed to determine the association between the time interval from insemination to vitrification and pregnancy rate. The findings suggest that the latest timing of vitrification is significantly associated with a higher pregnancy rate.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Bo Li, Yujin Lisa Kim, Alexander Ryan Lippert
Summary: This article discusses the application of chemiluminescence methods in detecting and measuring biological reactive sulfur and nitrogen species, as well as the development of emerging approaches, demonstrating their significance in physiology and pathophysiology. The future direction is the widespread adoption of these methods in living cells, animals, and human clinical samples, emphasizing rigorous quantitative methods and effective technology transfer.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Review
Chemistry, Analytical
Wanchao Yu, Lixia Zhao
Summary: ROS, as important oxidizing species in ecosystems, play various roles and monitoring their concentration is crucial for the environment. The chemiluminescence method has attracted attention for ROS detection due to its high sensitivity and simplicity, showing advances in recent years.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Review
Immunology
Huijun Chen, Xiaoli Zhang, Ge Lin, Fei Gong, Berthold Hocher
Summary: COVID-19 vaccination has potential effects on reproductive health in women undergoing assisted reproductive techniques. A study on 536 women undergoing IVF/ICSI treatment in China showed that COVID-19 vaccination may impair oocyte maturation, fertilization rate, and other reproductive outcomes. A systematic review of existing studies found that mRNA vaccines have no adverse effects on reproductive outcomes, while inactivated vaccines may affect oocyte maturation and fertilization rate.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Obstetrics & Gynecology
Meijuan Peng, Mingyang Wen, Tao Jiang, Yangqian Jiang, Hong Lv, Ting Chen, Xiufeng Ling, Hong Li, Qingxia Meng, Boxian Huang, Shiyao Tao, Lei Huang, Cong Liu, Xin Xu, Qun Lu, Xiaoyu Liu, Bo Xu, Xiumei Han, Kun Zhou, Jiaping Chen, Yuan Lin, Hongxia Ma, Yankai Xia, Hongbing Shen, Zhibin Hu, Feng Chen, Jiangbo Du, Guangfu Jin
Summary: This study aimed to investigate the association of pre-treatment psychological distress with clinical pregnancy rate among infertility couples undergoing IVF/ICSI treatment. The findings indicated that psychological distress experienced prior to treatment was not associated with clinical pregnancy outcomes.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Chemistry, Multidisciplinary
Wanchao Yu, Jin Xu, Fengjie Chen, Yarui Wang, Shanshan Tang, Fanglan Geng, Jitao Lv, Guangbo Qu, Lixia Zhao, Yawei Wang
Summary: This study reveals that persistent generation of reactive oxygen species (ROS) is involved in the self-degradation of few-layer black phosphorus (FLBP) even in the dark, and the patterns and mechanism of ROS generation are revealed. The ability of FLBP to remove rhodamine B (RhB) and methyl orange (MO) under dark conditions further indicates the generation of ROS during FLBP self-degradation. This work provides new insights into the self-degradation mechanism of FLBP and opens opportunities for practical applications.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Andrology
Andrew Peel, Anmol Saini, Joshua C. C. Deluao, Nicole O. O. McPherson
Summary: Obesity prevalence is rising globally, and recent studies have shown that paternal obesity negatively affects sperm parameters and increases the risk of infertility. Sperm DNA damage, a marker of sperm quality, may also be associated with obesity in men. However, the existing data on this association are conflicting. Other comorbidities of obesity, such as heat stress and insulin resistance, may also contribute to sperm DNA damage. In this review, the literature on the links between obesity in men, fertility, sperm parameters, and DNA damage is summarized, and potential mechanisms and implications are discussed.
Article
Endocrinology & Metabolism
Rong Luo, Jiahui Wang, Yu Yang, Cen Xu, Minyan Yang, Dandan Zhu, Jia Wang, Ping Zhang, Hongshan Ge
Summary: This study aimed to assess the impact of vitamin D levels on embryo quality and pregnancy outcomes in patients with normal ovarian reserve undergoing the first IVF/ICSI cycle. The findings suggest that serum vitamin D level is not associated with embryo quality and pregnancy outcomes for these patients. Further studies are needed to elucidate the relationships between vitamin D levels and IVF outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Chemistry, Applied
Pritha Biswas, Mohan Das, Somanath Boral, Gargi Mukherjee, Koel Chaudhury, Rintu Banerjee
CARBOHYDRATE POLYMERS
(2020)
Article
Medical Laboratory Technology
Amalesh Nanda, K. Thangapandi, Priyanka Banerjee, Mainak Dutta, Tsering Wangdi, Pramod Sharma, Koel Chaudhury, Saikat Kumar Jana
ANNALS OF LABORATORY MEDICINE
(2020)
Article
Engineering, Electrical & Electronic
Souvik Biswas, Arijit Pal, Koel Chaudhury, Soumen Das
Summary: A miniaturized paper-based disposable pH sensor has been developed for rapid detection of urine pH, with a high sensitivity of 1.6 k Omega/pH for acidic pH and 6.2 K Omega/pH for basic pH. The sensor has shown to be accurate in testing urine samples of healthy subjects and patients suffering from urinary tract infection (UTI), with an average accuracy of 95.53%.
IEEE SENSORS JOURNAL
(2021)
Review
Pharmacology & Pharmacy
Apoorva Singh, Sanjukta Dasgupta, Anindita Bhattacharya, Gayatri Mukherjee, Koel Chaudhury
Summary: Curcumin, a polyphenol found in turmeric, has the potential to be an alternative therapy for endometrial disorders. This review comprehensively examines the role and mechanism of curcumin in endometrial pathologies, and outlines future research directions.
DRUG DISCOVERY TODAY
(2022)
Article
Chemistry, Analytical
Ruchita Shandilya, Roshani Kumari, Neha Bunkar, Arpit Bhargava, Koel Chaudhury, Irina Yu Goryacheva, Pradyumna Kumar Mishra
Summary: A novel nano-photonic dual hybrid assay system for rapid and specific detection of circulating cell free mitochondrial DNA (ccf-mtDNA) was assessed, showing high feasibility, selectivity, and versatility in estimating ccfmtDNA in different analytical platforms for disease risk assessment.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Endocrinology & Metabolism
Priyanka Choudhury, Anindita Bhattacharya, Sanjukta Dasgupta, Nilanjana Ghosh, Sayoni Senpupta, Mamata Joshi, Parthasarathi Bhattacharyya, Koel Chaudhury
Summary: This study aims to identify metabolic alterations in COPD-PH patients compared to healthy controls. The findings show that 15 serum and 9 EBC metabolites were significantly altered in COPD-PH patients. Lactate and pyruvate were dysregulated in both biofluids and correlated with echocardiographic sPAP.
Article
Biochemistry & Molecular Biology
Sanjukta Dasgupta, Nilanjana Ghosh, Priyanka Choudhury, Mamata Joshi, Sushmita Roy Chowdhury, Parthasarathi Bhattacharyya, Koel Chaudhury
Summary: Hypersensitivity pneumonitis is an immune-mediated granulomatous interstitial lung disease resulting from repeated inhalation of certain antigens. Metabolomic and transcriptomic analysis revealed alterations in metabolic and gene expression profiles of HP patients compared to healthy controls, suggesting potential diagnostic markers differentiating HP from other lung diseases.
Article
Environmental Sciences
Pradyumna Kumar Mishra, Arpit Bhargava, Roshani Kumari, Neha Bunkar, Prachi Chauhan, Suranjana Mukherjee, Ruchita Shandilya, Radha Dutt Singh, Rajnarayan Tiwari, Koel Chaudhury
Summary: This study reveals increased mitochondrial stress and oxidative DNA damage in individuals exposed to airborne particulate matter. It also identifies changes in mitochondrial biogenesis and expression of mitochondrial function genes in relation to the disturbances in mitochondrial genome. Furthermore, it highlights the disrupted activity of electron chain complexes and altered mtDNA methylation in high-risk group.
ATMOSPHERIC POLLUTION RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Pooja Ghosh, Sudipta Bag, Sultana Parveen, Elavarasan Subramani, Koel Chaudhury, Swagata Dasgupta
Summary: Nanoencapsulation is a promising approach for delivering poorly aqueous soluble compounds. In this study, HSA-based and PLGA-based nanoparticles were prepared to deliver the morin-Cu(II) complex. The nanoparticles showed controlled release, antioxidant activity, antibacterial activity, and anticancer activity, making them potential delivery systems for the morin-Cu(II) complex.
Article
Respiratory System
Sanjukta Dasgupta, Anindita Bhattacharya, Rajwade Dhruva Abhijit, Sushmita Roy Chowdhury, Koel Chaudhury
Summary: This systematic review and meta-analysis study suggests that increased age, male sex, honeycombing, and traction bronchiectasis patterns on high-resolution computed tomography (HRCT) images are the major mortality-related risk factors of patients with hypersensitivity pneumonitis (HP). Antigen exposure appears to be an additional risk factor for chronic HP. These findings can help clinicians better monitor and manage patients.
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2022)
Review
Medical Laboratory Technology
Sanjukta Dasgupta, Nilanjana Ghosh, Parthasarathi Bhattacharyya, Sushmita Roy Chowdhury, Koel Chaudhury
Summary: Asthma and chronic obstructive pulmonary disease (COPD) are common lung diseases that have a significant impact on morbidity and mortality worldwide. Asthma-COPD overlap (ACO) is a complex pulmonary disease that shares features of both asthma and COPD. This review examines the metabolic alterations in patients with asthma, COPD, and ACO, and discusses the use of metabolomics techniques for biomarker discovery and understanding the pathogenesis of these diseases. The review also highlights the challenges in metabolite identification and quality assessment, and envisions bridging the gap between phenotype and metabotype in the future.
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
(2023)
Article
Nanoscience & Nanotechnology
Arijit Pal, Souvik Biswas, Koel Chaudhury, Soumen Das
Summary: The sensing behavior of a MoS2-functionalized paper sensor towards dopamine was investigated using theoretical analysis, experimental validation, and machine learning-driven predictive modeling. The suitability of MoS2 for detecting dopamine was confirmed through density functional theory. Theoretical analysis revealed the physisorption behavior and electrostatic interaction of dopamine on MoS2, while experimental results confirmed the alteration in dopamine's oxidation potential. The developed sensor showed high accuracy in detecting dopamine in serum samples, with an average accuracy of over 96% and a detection limit of 10 nM. Implementation of a machine-intelligent web app interface further improved the sensing platform's resolution and accuracy to nearly 99%.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biotechnology & Applied Microbiology
Sanjukta Dasgupta, Sankha Subhra Das, Sankalp Patidar, Vaibhav Kajaria, Sushmita Roy Chowdhury, Koel Chaudhury
Summary: The study identifies common differentially expressed genes (DEGs) in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and hypersensitivity pneumonitis (HP), which are involved in complement activation and growth factor activity. Using a random forest classifier, the study demonstrates high accuracy in differentiating COVID-19 and HP from control groups, providing new molecular leads for diagnostics and therapeutics research.
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Tila Khan, Sanjukta Dasgupta, Nilanjana Ghosh, Koel Chaudhury
Summary: Idiopathic pulmonary fibrosis (IPF) is a debilitating lung disease with unclear etiology and pathophysiology. Proteomics has shown promise in identifying important biomarkers for IPF, but further validation is needed.
Article
Respiratory System
Nilanjana Ghosh, Priyanka Choudhury, Sandeep Rai Kaushik, Rakesh Arya, Ranjan Nanda, Parthasarathi Bhattacharyya, Sushmita Roychowdhury, Rintu Banerjee, Koel Chaudhury
RESPIRATORY RESEARCH
(2020)