Journal
SYNTHETIC METALS
Volume 198, Issue -, Pages 41-50Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.synthmet.2014.09.017
Keywords
Polyaniline; Poly-epsilon-caprolactone; Electrospinning; Free radical scavenging and biocompatibility
Funding
- New Zealand Ministry of Business, Innovation & Employment (MBIE) [UOAX0812]
- New Zealand Ministry of Business, Innovation & Employment (MBIE) [UOAX0812] Funding Source: New Zealand Ministry of Business, Innovation & Employment (MBIE)
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Fiber-scaffolds consisting of poly-epsilon-caprolactone (PCL) and polyaniline (PANI) were obtained from electrospinning of PCL solutions, in chloroform/methanol, containing nanofibrous polyaniline (nfPANI). The resultant fiber-scaffolds diameters are 155 +/- 55 nm (neat PCL) to 144 +/- 59 nm (PCL containing 20% w/w PANI). Incorporating PANI (20% w/w) in PCL resulted in improvements of physical properties, including: increased in electrical conductivity; improved hydrophilicity; and increased in free radical-scavenging capacity (2,2-diphenycl-l-picrylhydrazyl, DPPI-1.). The cytotoxicity of PCL/PANI fiber-scaffolds was determined by proliferation of L929 fibroblast cells on the scaffolds collected on glass substrates. Cell attachment and proliferation of L929 cells on the fiber-scaffolds were not affected by the presence of PANI; and the morphologies of L929 cells were indistinguishable to those grown on tissue culture plates (TCP), suggesting PCL/PANI scaffolds are non-toxic and could potentially be suitable for biomedical applications. (C) 2014 Elsevier B.V. All rights reserved.
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