Journal
SYNTHETIC COMMUNICATIONS
Volume 44, Issue 17, Pages 2427-2457Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00397911.2014.907426
Keywords
2-Amino benzothiazole; benzothiazole; fused heterocyclic compound; multicomponent reactions (MCR); thiazole derivative
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Funding
- University Grants Commission-BSR
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Benzothiazole is used as a building block in organic synthesis, which serves as a key template for the development of various therapeutic agents and shows a wide spectrum of activities. The attractive application of benzothiazole in organic synthesis is undoubtedly due to the highly reactive C-2 amino group, which is responsible for the change in its bioactivity. The construction of a poly-heterocyclic compound with the fused hetero-systems has attracted increasing attention because of the diverse range of potential therapeutic activities. Significant efforts have been undertaken to exploit different synthetic routes to these compounds. This article gives a comprehensive account of the synthetic utility of benzothiazole employed in the design and synthesis of different types of compounds containing fused heterocyclic rings with greater emphasis on recent literature.
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