Journal
SYNTHETIC COMMUNICATIONS
Volume 44, Issue 1, Pages 89-100Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00397911.2013.789527
Keywords
Heterogeneous catalyst; mesoporous SBA-15; multi-component reaction; spirochromenes
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Funding
- Research Council of Mazandaran University
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Immobilized 1,4-diazabicyclo[2.2.2]octane (DABCO) over mesoporous silica SBA-15 has been found to be an efficient heterogeneous base catalyst for the synthesis of biologically active functionalized spirochromene derivatives via three-component reaction of isatins/acenaphthoquinone, activated methylene reagents, and 1,3-dicarbonyl compounds in aqueous media. This ecofriendly protocol offers several advantages such as a cost-effective procedure with excellent yield, short reaction time, simple workup, recovery and reusability of catalyst, good functional group tolerance, and broad scope of usable substrates. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) for the following free supplemental resource(s): Full experimental and spectral details.]
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