Journal
SYNTHETIC COMMUNICATIONS
Volume 44, Issue 2, Pages 181-187Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00397911.2013.796523
Keywords
Arene; bromination; KBr
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Funding
- National Science Foundation of China [21002045, 21272096]
- Fundamental Research Funds for the Central Universities [lzujbky-2012-55]
- State Key Laboratory of Applied Organic Chemistry and Lanzhou University
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An efficient and environmentally benign bromination of various aromatic compounds using aN aqueous I2O5-KBr system at room temperature has been developed in this work. A series of aromatic compounds such as acetophenones, benzaldehydes, benzoic acids, anilines, amides, and aminopyridine have been successfully brominated in excellent regioselectivities and good yields under the typical reaction conditions. The features of KBr as brominating reagent, water as solvent, and mild conditions make this system an attractive synthetic procedure. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) for the following free supplemental resource(s): Full experimental and spectral details.]
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