Review
Chemistry, Organic
Tanzeela Qadir, Andleeb Amin, Alka Salhotra, Praveen Kumar Sharma, Ishtiaq Jeelani, Hitoshi Abe
Summary: Benzothiazole derivatives have been extensively studied in the fields of synthetic and medicinal chemistry due to their significant pharmaceutical properties. These compounds exhibit a wide range of biological activities, including anti-inflammatory, anticancer, and antibacterial effects. This review discusses various reaction methods for the synthesis of different benzothiazole derivatives.
CURRENT ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Youngran Seo, Jared M. Lowe, Neyen Romano, Michel R. Gagne
Summary: A variety of C-glycosides can be synthesized through a one-step functionalization process by changing the addition order, Lewis acid, and TMS-X, resulting in common C-pyranosides, rare C-furanosides, and virtually unknown anhydro-C-pyranosides. These synthons are obtained through different mechanisms such as direct substitution, isomerization/substitution, or substitution/isomerization.
Article
Chemistry, Multidisciplinary
Akira Saito, Shinya Adachi, Naoya Kumagai, Masakatsu Shibasaki
Summary: The strategic use of a sterically demanding Ni-II pincer carbene complex has enabled high enantioselectivity in the direct catalytic asymmetric addition of acetonitrile to aldehydes, resulting in highly enantioenriched beta-hydroxynitriles. This highly atom-economical process offers a promising pathway for utilizing inexpensive acetonitrile as a C2 building block in practical synthetic toolbox for asymmetric catalysis.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biochemistry & Molecular Biology
Pola Cybulska, Yves-Marie Legrand, Alicja Babst-Kostecka, Sebastien Diliberto, Anna Lesniewicz, Erwan Oliviero, Valerie Bert, Clotilde Boulanger, Claude Grison, Tomasz K. Olszewski
Summary: A green and effective approach for the synthesis of structurally diversed alpha-hydroxyphosphonates via hydrophosphonylation of aldehydes under solventless conditions and promoted by biosourced catalysts Eco-MgZnOx is presented. The ecocatalysts were prepared from Zn-hyperaccumulating plant species Arabidopsis halleri, with simple and benign thermal treatment of leaves rich in Zn, and without any further chemical treatment. The study demonstrates the potential use of the ecocatalysts in hydrophosphonylation of aldehydes, leading to various alpha-hydroxyphosphonate derivatives, which are critical building blocks in the modern chemical industry.
Article
Chemistry, Organic
Fang Fang, Jie Xia, Siying Quan, Shanping Chen, Guo-Jun Deng
Summary: A simple and practical method for the preparation of substituted pyrimidines from ketones, NH4OAc, and N,N-dimethylformamide dimethyl acetal is described in this study. The NH4I-promoted three-component tandem reaction offers a broad range of substituted pyrimidines in acceptable yields under metal- and solvent-free conditions. This methodology has the advantages of easily accessible starting materials, simple reaction conditions, and high synthetic yields.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Analytical
Jida Wang, Zhangshuai Ding, Feng Shi, Yifei Chen, Defa Hou, Fulin Yang, Can Liu, Yi Lu, Xu Lin, Zhifeng Zheng, Yunwu Zheng
Summary: An efficient CaO-MgO-promoting γ-Al2O3 decarboxylation catalyst was prepared via ball-milling method for regulating product distribution and production of hydrocarbons. The catalyst showed high selectivity in the catalytic copyrolysis of oleic acid and methanol. Factors influencing the reaction, reaction mechanisms, possible pathways, and deactivation mechanisms were investigated. Methanol addition enhanced biogasoline selectivity and reduced coke deposition.
JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS
(2023)
Article
Materials Science, Multidisciplinary
M. Shashank, H. S. Bhojya Naik, J. Shashikanth, Aatika Nizam, G. Nagaraju
Summary: The research focuses on the use of zirconium phosphate nanoparticles for photocatalytic degradation of dyes, showing higher efficiency in basic conditions. Additionally, zirconium phosphate is also used as a catalyst for the nitration of aldehydes in different solvents.
BULLETIN OF MATERIALS SCIENCE
(2021)
Article
Chemistry, Physical
Hafsa Karroum, Sergey Chenakin, Sergei Alekseev, Viacheslav Iablokov, Yizhi Xiang, Vincent Dubois, Norbert Kruse
Summary: This study presents a one-step-one-pot synthesis of chain-lengthened aliphatic amines and nitriles using potassium-promoted Co/MnOx catalysts, showing that the reaction can be tuned by adjusting the H-2/CO ratio. Additionally, the addition of NH3 strongly favors the formation of chain-lengthened olefins over alkanes.
Article
Engineering, Chemical
Ioannis Nikolopoulos, George Kogkos, Chrysanthi Andriopoulou, Eleana Kordouli, Vassileios Dracopoulos, Kyriakos Bourikas, Christos Kordulis, Alexis Lycourghiotis
Summary: Cobalt-alumina catalysts with high cobalt loading were synthesized, and the most efficient catalyst for green diesel production was found to contain 55 wt% cobalt activated at 500 degrees C. The catalysts exhibited lower performance in the deoxygenation of waste cooking oil compared to sunflower oil, likely due to deactivation caused by coking and pore blockage.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Timon Schoenauer, Sabrina L. J. Thomae, Leah Kaiser, Mirijam Zobel, Rhett Kempe
Summary: The development of C-N bond formation reactions is crucial in biology and chemistry, with recent progress in 3d metal catalysis showing unique selectivity patterns. By using a novel cobalt catalyst, a catalytic C-N bond formation reaction was successfully reported, utilizing abundant and low-cost starting materials for reductive alkylation.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Organic
Guofu Zhang, Huihui Miao, Chenfei Guan, Chengrong Ding
Summary: The direct transformation of aryl carboxylic acids to aryl nitriles has been achieved through palladium-catalyzed decarbonylative cyanation without the use of a base. Successful analysis of the decarbonylative cyanation of drug molecules and gram-scale reactions validates the practicality and operability of this method.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Olivia Goethe, Mikaela DiBello, Seth B. Herzon
Summary: This study presents a total synthesis platform for pleuromutilins, allowing access to derivatives with alterations at previously inaccessible positions. The synthesis is enabled by the discovery of a vinylogous Wolff rearrangement and a highly diastereoselective butynylation reaction.
Article
Chemistry, Inorganic & Nuclear
Ethan Zars, Lisa Gravogl, Michael Gau, Patrick J. Carroll, Karsten Meyer, Daniel J. Mindiola
Summary: The synthesis and characterization of mono-benzaldimine and bis-benzaldimine complexes were investigated. It was found that the mono-benzaldimine complex can produce free HN.CHPh under catalytic conditions. The study also elucidated the conversion of HN = CHPh in the bis-benzaldimine complexes to C-C and C-N coupled products.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
John J. Monteith, Sophie A. L. Rousseaux
Summary: A Negishi cross-coupling method has been developed for the synthesis of alpha-aryl ester products using alpha-hydroxy ester derivatives and arylzinc reagents. This reaction is efficient, rapid, and mild, providing a complementary way of accessing desirable products.
Article
Chemistry, Multidisciplinary
Rawan Al-Faze, Elena F. Kozhevnikova, Ivan Kozhevnikov
Summary: The conversion of diethyl ether (DEE) to ethene and ethanol over various acid catalysts showed a correlation between catalyst activity and acid strength, with Bronsted acid sites playing an important role in the reaction, proceeding through a consecutive pathway. The HPA catalysts outperformed other catalysts, indicating the superior performance of strong acid catalysts in DEE elimination.
Article
Chemistry, Multidisciplinary
Arvind K. Yadav, Lal Dhar S. Yadav
CHEMICAL COMMUNICATIONS
(2016)
Article
Chemistry, Multidisciplinary
Arvind K. Yadav, Lal Dhar S. Yadav
Article
Chemistry, Organic
Arvind K. Yadav, Lai Dhar S. Yadav
TETRAHEDRON LETTERS
(2016)
Article
Chemistry, Multidisciplinary
Arvind Kumar Yadav, Krishna Nand Singh
NEW JOURNAL OF CHEMISTRY
(2017)
Article
Chemistry, Organic
Manjula Singh, Arvind K. Yadav, Lal Dhar S. Yadav, R. K. P. Singh
Article
Chemistry, Organic
Arvind K. Yadav, Lal Dhar S. Yadav
TETRAHEDRON LETTERS
(2017)
Article
Chemistry, Organic
Manjula Singh, Arvind K. Yadav, Lal Dhar S. Yadav, R. K. P. Singh
TETRAHEDRON LETTERS
(2017)
Article
Chemistry, Organic
Manjula Singh, Arvind K. Yadav, Lal Dhar S. Yadav, Rana Krishna Pal Singh
TETRAHEDRON LETTERS
(2018)
Article
Chemistry, Organic
Manjula Singh, Arvind K. Yadav, Lal Dhar S. Yadav, Rana Krishna Pal Singh
Article
Chemistry, Organic
Anup Kumar Sharma, Arvind Kumar Yadav, Krishna Nand Singh
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2018)
Article
Chemistry, Organic
Prince Kumar Gupta, Arvind Kumar Yadav, Krishna Nand Singh
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2020)
Article
Chemistry, Organic
Arvind K. Yadav, Srikanth Reddy Narra, Muhamad Zulfaqar Bacho, Yuji Sumii, Norio Shibata
Summary: A convenient method for the activation of aryl-oximes using TFEDMA as a scalable and efficient reagent is reported. Aryl-aldoximes led to aryl-cyanides, while aryl-ketoximes provided aryl-amides in moderate to excellent yields. The iminium form of TFEDMA acted as a fluorinated version of the well-known Vilsmeier reagent. Aryl cyanides and aryl amides are valuable synthetic units in natural products and drug candidates.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Arvind Kumar Yadav
Summary: A metal-free denitrative trifluoromethylation reaction was developed using Langlois' reagent and (NH4)2S2O8 as a radical initiator, resulting in the synthesis of vinyltrifluoromethylated alkenes under mild reaction conditions.
RESULTS IN CHEMISTRY
(2022)
Article
Chemistry, Organic
Prince Kumar Gupta, Arvind Kumar Yadav, Anup Kumar Sharma, Krishna Nand Singh
Summary: Metal-free iodine-catalyzed regioselective thioallylation of indoles has been achieved at room temperature using Bunte salts prepared from Baylis-Hillman bromides. The resulting multi-functional C3 thioallylated indoles exhibit ample structural diversity and good functional group tolerance.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Organic
Arvind Kumar Yadav, Anup Kumar Sharma, Krishna Nand Singh
ORGANIC CHEMISTRY FRONTIERS
(2019)
Article
Chemistry, Organic
Dilek Isik Tasgin, Irem Bayraktar
Summary: We present a synthetic method for pyrrolizine-3-one derivatives and investigate their photophysical properties. These compounds are prepared through a series of reactions involving substituted pyrroles in one-pot, two-step oxidation, and intramolecular cyclization processes. The photophysical properties of the synthesized compounds are studied using UV-Vis and fluorescence spectroscopy in various solvents. The introduction of pyrrolyl substituents has a significant impact on Stokes shifts and quantum yield values.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Organic
Satish Kumar Burra, Vaikunta Rao Lakinani, Raghunadh Akula, Chiranjeevi Yankkanti
Summary: A novel and green strategy for the construction of biologically relevant substituted indolyl-4H-chromenes scaffolds is reported, using L-proline as a catalyst and water as a promoter solvent. This catalytic system offers wider applicability, shorter reaction times, and high yields, making it an ideal condition for green chemistry.
SYNTHETIC COMMUNICATIONS
(2024)
Review
Chemistry, Organic
Abouelhaoul El Alami, Amine El Maraghi, Fatima Youssoufi, Assiya Atif, Hamid Sdassi
Summary: Nitrobenzimidazoles have become increasingly important in the design of new compounds in medicinal, therapeutic and chemical fields. This review provides an overview of the synthesis strategies and biological activities of nitrobenzimidazole derivatives.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Organic
Nilesh Raghunath Khedkar, Alex Joseph, Milind Sindkhedkar
Summary: In this study, a new library of 3-(2-(pyrimidin-5-yl)thiazol-4-yl)-1,2,4-oxadiazole compounds was designed and synthesized as potential anticancer agents using in silico fragment-based drug design. The compounds were tested for their anticancer activity in vitro, and one compound exhibited excellent activity against multiple cancer cell lines.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Organic
Terungwa H. Iorkula, Bryce A. Tolman, Scott R. Burt, Matt A. Peterson
Summary: A new method for synthesizing C-6 substituted products has been discovered in this study, which utilizes lower doses of fluoride and CsF as a catalyst, with high reaction yields and cost-effectiveness under suitable conditions.
SYNTHETIC COMMUNICATIONS
(2024)
Review
Chemistry, Organic
Ranjana Aggarwal, Swati Sharma
Summary: This review article mainly focuses on the synthesis of 3(5)-trifluoromethylpyrazoles via condensation reaction of trifluoromethyl-beta-diketones with hydrazines. It emphasizes the importance of fluorine-containing compounds and pyrazoles in the field of biology. The literature reported condensation reactions of trifluoromethyl-beta-diketones with hydrazines are covered.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Organic
F. M. Alshareef, Sami A. Al-Harbi, Esam S. Allehyani, Omeima Abdullah, Magdy A. Ibrahim
Summary: This study aimed to construct a novel category of linear annulated chromeno[3',2':5,6]pyrido[2,3-d][1,3]thiazolo[3,2-a]pyrimidines. The chemical reactivity of the synthesized compounds was investigated, and they showed significant antimicrobial activity against various strains.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Organic
Preethi Dhanapal, S. L. Manju
Summary: Thiazole based Schiff base scaffolds have become an integral part of drug development in recent years, playing a versatile role as building blocks for lead drug molecules. This study presents a facile one pot synthetic method for producing novel 4-aryl thiazoles with high yield, shorter reaction time, and milder conditions, without the need for catalysts or purification techniques.
SYNTHETIC COMMUNICATIONS
(2024)
