Progress on adenovirus-vectored universal influenza vaccines

Evaluation of a fully human monoclonal antibody against multiple influenza A viral strains in mice and a pandemic H1N1 strain in nonhuman primates

(2014) Aihua Song et al.   ANTIVIRAL RESEARCH

CD40 Ligand Preferentially Modulates Immune Response and Enhances Protection against Influenza Virus

(2014) Anwar M. Hashem et al.   JOURNAL OF IMMUNOLOGY

Intranasal Adenovirus-Vectored Vaccine for Induction of Long-Lasting Humoral Immunity-Mediated Broad Protection against Influenza in Mice

(2014) E. H. Kim et al.   JOURNAL OF VIROLOGY

Targeting the HA2 subunit of influenza A virus hemagglutinin via CD40L provides universal protection against diverse subtypes

(2014) X Fan et al.   Mucosal Immunology

Broadly neutralizing hemagglutinin stalk–specific antibodies require FcγR interactions for protection against influenza virus in vivo

(2014) David J DiLillo et al.   NATURE MEDICINE

Glycan Masking of Hemagglutinin for Adenovirus Vector and Recombinant Protein Immunizations Elicits Broadly Neutralizing Antibodies against H5N1 Avian Influenza Viruses

(2014) Shih-Chang Lin et al.   PLoS One

Live attenuated influenza A virus vaccine protects against A(H1N1)pdm09 heterologous challenge without vaccine associated enhanced respiratory disease

(2014) Phillip C. Gauger et al.   VIROLOGY

A recombinant adenovirus-based vector elicits a specific humoral immune response against the V3 loop of HIV-1 gp120 in mice through the “Antigen Capsid-Incorporation” strategy

(2014) Linlin Gu et al.   Virology Journal

Immunization with Hexon Modified Adenoviral Vectors Integrated with gp83 Epitope Provides Protection against Trypanosoma cruzi Infection

(2014) Anitra L. Farrow et al.   PLoS Neglected Tropical Diseases

Conserved epitopes dominate cross-CD8+T-cell responses against influenza A H1N1 virus among Asian populations

(2013) Jun Liu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

H3 Stalk-Based Chimeric Hemagglutinin Influenza Virus Constructs Protect Mice from H7N9 Challenge

(2013) F. Krammer et al.   JOURNAL OF VIROLOGY

Hemagglutinin Stalk-Based Universal Vaccine Constructs Protect against Group 2 Influenza A Viruses

(2013) I. Margine et al.   JOURNAL OF VIROLOGY

Chimeric Hemagglutinin Influenza Virus Vaccine Constructs Elicit Broadly Protective Stalk-Specific Antibodies

(2013) F. Krammer et al.   JOURNAL OF VIROLOGY

Safety and immunogenicity of an oral, replicating adenovirus serotype 4 vector vaccine for H5N1 influenza: a randomised, double-blind, placebo-controlled, phase 1 study

(2013) Marc Gurwith et al.   LANCET INFECTIOUS DISEASES

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(2013) Teresa Lambe   MOLECULAR MEDICINE

Antigen-specific B-cell receptor sensitizes B cells to infection by influenza virus

(2013) Stephanie K. Dougan et al.   NATURE

Universal influenza virus vaccines: need for clinical trials

(2013) Florian Krammer et al.   NATURE IMMUNOLOGY

Cellular immune correlates of protection against symptomatic pandemic influenza

(2013) Saranya Sridhar et al.   NATURE MEDICINE

Broadly Protective Adenovirus-Based Multivalent Vaccines against Highly Pathogenic Avian Influenza Viruses for Pandemic Preparedness

(2013) Sai V. Vemula et al.   PLoS One

Production and stabilization of the trimeric influenza hemagglutinin stem domain for potentially broadly protective influenza vaccines

(2013) Y. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vaccine-Induced Anti-HA2 Antibodies Promote Virus Fusion and Enhance Influenza Virus Respiratory Disease

(2013) S. Khurana et al.   Science Translational Medicine

Vaccine-Associated Enhanced Respiratory Disease Does Not Interfere with the Adaptive Immune Response Following Challenge with Pandemic A/H1N1 2009

(2013) Phillip C. Gauger et al.   VIRAL IMMUNOLOGY

Acute emergence and reversion of influenza A virus quasispecies within CD8+ T cell antigenic peptides

(2013) Sophie A. Valkenburg et al.   Nature Communications

Immunity Against Heterosubtypic Influenza Virus Induced By Adenovirus And MVA Expressing Nucleoprotein And Matrix Protein-1

(2013) Teresa Lambe et al.   Scientific Reports

Cooperativity Between CD8+ T Cells, Non-Neutralizing Antibodies, and Alveolar Macrophages Is Important for Heterosubtypic Influenza Virus Immunity

(2013) Brian J. Laidlaw et al.   PLoS Pathogens

High Titer and Avidity of Nonneutralizing Antibodies against Influenza Vaccine Antigen Are Associated with Severe Influenza

(2012) Kelvin K. W. To et al.   Clinical and Vaccine Immunology

The Contribution of Systemic and Pulmonary Immune Effectors to Vaccine-Induced Protection from H5N1 Influenza Virus Infection

(2012) Y.-F. Lau et al.   JOURNAL OF VIROLOGY

Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans

(2012) Tom M Wilkinson et al.   NATURE MEDICINE

Protection against Enterovirus 71 with Neutralizing Epitope Incorporation within Adenovirus Type 3 Hexon

(2012) Xingui Tian et al.   PLoS One

A distinct lineage of influenza A virus from bats

(2012) S. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Highly Conserved Protective Epitopes on Influenza B Viruses

(2012) C. Dreyfus et al.   SCIENCE

Vaccine Vectors Derived from a Large Collection of Simian Adenoviruses Induce Potent Cellular Immunity Across Multiple Species

(2012) S. Colloca et al.   Science Translational Medicine

Fully human broadly neutralizing monoclonal antibodies against influenza A viruses generated from the memory B cells of a 2009 pandemic H1N1 influenza vaccine recipient

(2012) Weibin Hu et al.   VIROLOGY

Subcutaneous immunization with recombinant adenovirus expressing influenza A nucleoprotein protects mice against lethal viral challenge

(2012) Anwar Hashem et al.   Human Vaccines & Immunotherapeutics

Early Priming Minimizes the Age-Related Immune Compromise of CD8+ T Cell Diversity and Function

(2012) Sophie A. Valkenburg et al.   PLoS Pathogens

The route of immunization with adenoviral vaccine influences the recruitment of cytotoxic T lymphocytes in the lung that provide potent protection from influenza A virus

(2011) Tatsuya Suda et al.   ANTIVIRAL RESEARCH

CD40L-Containing Virus-Like Particle as a Candidate HIV-1 Vaccine Targeting Dendritic Cells

(2011) David Franco et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Human adenovirus-specific T cells modulate HIV-specific T cell responses to an Ad5-vectored HIV-1 vaccine

(2011) Nicole Frahm et al.   JOURNAL OF CLINICAL INVESTIGATION

Contributions of Antinucleoprotein IgG to Heterosubtypic Immunity against Influenza Virus

(2011) Mark W. LaMere et al.   JOURNAL OF IMMUNOLOGY

Comparative Immunogenicity and Cross-Clade Protective Efficacy of Mammalian Cell-Grown Inactivated and Live Attenuated H5N1 Reassortant Vaccines in Ferrets

(2011) K. M. Gustin et al.   JOURNAL OF INFECTIOUS DISEASES

Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine

(2011) Scott G. Hansen et al.   NATURE

Recombinant Trimeric HA Protein Immunogenicity of H5N1 Avian Influenza Viruses and Their Combined Use with Inactivated or Adenovirus Vaccines

(2011) Shih-Chang Lin et al.   PLoS One

Adenovirus-Vectored Drug-Vaccine Duo as a Rapid-Response Tool for Conferring Seamless Protection against Influenza

(2011) Jianfeng Zhang et al.   PLoS One

Systematic identification of immunodominant CD8+ T-cell responses to influenza A virus in HLA-A2 individuals

(2011) C. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Neutralizing Antibody Selected from Plasma Cells That Binds to Group 1 and Group 2 Influenza A Hemagglutinins

(2011) D. Corti et al.   SCIENCE

A Highly Conserved Neutralizing Epitope on Group 2 Influenza A Viruses

(2011) D. C. Ekiert et al.   SCIENCE

International seroepidemiology of adenovirus serotypes 5, 26, 35, and 48 in pediatric and adult populations

(2011) Dan H. Barouch et al.   VACCINE

Aerosol vaccination induces robust protective immunity to homologous and heterologous influenza infection in mice

(2011) Jennifer Humberd Smith et al.   VACCINE

Co-administration of certain DNA vaccine combinations expressing different H5N1 influenza virus antigens can be beneficial or detrimental to immune protection

(2011) Ami Patel et al.   VACCINE

Cross-Reactive T Cells Are Involved in Rapid Clearance of 2009 Pandemic H1N1 Influenza Virus in Nonhuman Primates

(2011) Jason T. Weinfurter et al.   PLoS Pathogens

Assessment of Route of Administration and Dose Escalation for an Adenovirus-Based Influenza A Virus (H5N1) Vaccine in Chickens

(2010) J. Steitz et al.   Clinical and Vaccine Immunology

Influenza epidemiology—past, present, and future

(2010) Philippe R. S. Lagacé-Wiens et al.   CRITICAL CARE MEDICINE

CD40-Targeted Recombinant Adenovirus Significantly Enhances the Efficacy of Antitumor Vaccines Based on Dendritic Cells and B Cells

(2010) Yun-Sun Kim et al.   HUMAN GENE THERAPY

Identification of broad binding class I HLA supertype epitopes to provide universal coverage of influenza A virus

(2010) Jeff Alexander et al.   HUMAN IMMUNOLOGY

Quality of the Transgene-Specific CD8+ T Cell Response Induced by Adenoviral Vector Immunization Is Critically Influenced by Virus Dose and Route of Vaccination

(2010) P. J. Holst et al.   JOURNAL OF IMMUNOLOGY

Development of adenoviral vector-based mucosal vaccine against influenza

(2010) Irina L. Tutykhina et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Route of Adenovirus-Based HIV-1 Vaccine Delivery Impacts the Phenotype and Trafficking of Vaccine-Elicited CD8+ T Lymphocytes

(2010) D. R. Kaufman et al.   JOURNAL OF VIROLOGY

Adenovirus-Based Vaccines: Comparison of Vectors from Three Species ofAdenoviridae

(2010) H. Chen et al.   JOURNAL OF VIROLOGY

Attenuation of inducible respiratory immune responses by oseltamivir treatment in mice infected with influenza A virus

(2010) Etsuhisa Takahashi et al.   MICROBES AND INFECTION

Capsid-Incorporation of Antigens into Adenovirus Capsid Proteins for a Vaccine Approach

(2010) Qiana L. Matthews   MOLECULAR PHARMACEUTICS

IEDB-3D: structural data within the immune epitope database

(2010) J. Ponomarenko et al.   NUCLEIC ACIDS RESEARCH

Comparative Efficacy of Hemagglutinin, Nucleoprotein, and Matrix 2 Protein Gene-Based Vaccination against H5N1 Influenza in Mouse and Ferret

(2010) Srinivas S. Rao et al.   PLoS One

A Candidate H1N1 Pandemic Influenza Vaccine Elicits Protective Immunity in Mice

(2010) Julia Steitz et al.   PLoS One

A Porcine Adenovirus with Low Human Seroprevalence Is a Promising Alternative Vaccine Vector to Human Adenovirus 5 in an H5N1 Virus Disease Model

(2010) Ami Patel et al.   PLoS One

Induction of type I interferon by adenovirus-encoded small RNAs

(2010) T. Yamaguchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cross-reactive CD8+T-cell immunity between the pandemic H1N1-2009 and H1N1-1918 influenza A viruses

(2010) Stephanie Gras et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vaccination with a synthetic peptide from the influenza virus hemagglutinin provides protection against distinct viral subtypes

(2010) T. T. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design of an HA2-based Escherichia coli expressed influenza immunogen that protects mice from pathogenic challenge

(2010) G. Bommakanti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic immunization in the lung induces potent local and systemic immune responses

(2010) K. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of Human Adenovirus at 3.5 A Resolution

(2010) V. S. Reddy et al.   SCIENCE

Induction of Broadly Neutralizing H1N1 Influenza Antibodies by Vaccination

(2010) C.-J. Wei et al.   SCIENCE

Long-Term Thermostabilization of Live Poxviral and Adenoviral Vaccine Vectors at Supraphysiological Temperatures in Carbohydrate Glass

(2010) R. Alcock et al.   Science Translational Medicine

CD40 ligand expressed in adenovirus can improve the immunogenicity of the GP3 and GP5 of porcine reproductive and respiratory syndrome virus in swine

(2010) Jun Cao et al.   VACCINE

Potent immune responses and in vitro pro-inflammatory cytokine suppression by a novel adenovirus vaccine vector based on rare human serotype 28

(2010) Christoph A. Kahl et al.   VACCINE

Adenovirus-specific human T cells are pervasive, polyfunctional, and cross-reactive

(2010) Natalie A. Hutnick et al.   VACCINE

Utilization of serologic assays to support efficacy of vaccines in nonclinical and clinical trials: Meeting at the Crossroads

(2010) Dace V. Madore et al.   VACCINE

Adenoviral Producer Cells

(2010) Imre Kovesdi et al.   Viruses-Basel

Influenza Virus Vaccine Based on the Conserved Hemagglutinin Stalk Domain

(2010) J. Steel et al.   mBio

Broadly Protective Monoclonal Antibodies against H3 Influenza Viruses following Sequential Immunization with Different Hemagglutinins

(2010) Taia T. Wang et al.   PLoS Pathogens

Optimization of vaccine responses with an E1, E2b and E3-deleted Ad5 vector circumvents pre-existing anti-vector immunity

(2009) T Osada et al.   CANCER GENE THERAPY

Influenza Virus Resistance to Antiviral Agents: A Plea for Rational Use

(2009) Gregory A. Poland et al.   CLINICAL INFECTIOUS DISEASES

Engineered adenovirus serotypes for overcoming anti-vector immunity

(2009) Sridhar Dharmapuri et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Overcoming pre-existing adenovirus immunity by genetic engineering of adenovirus-based vectors

(2009) Sergey S Seregin et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Adenovirus as a carrier for the development of influenza virus-free avian influenza vaccines

(2009) De-chu C Tang et al.   Expert Review of Vaccines

Effect of Preexisting Immunity on an Adenovirus Vaccine Vector: In Vitro Neutralization Assays Fail To Predict Inhibition by Antiviral Antibody In Vivo

(2009) S. L. Pichla-Gollon et al.   JOURNAL OF VIROLOGY

Intranasal Vaccination with 1918 Influenza Virus-Like Particles Protects Mice and Ferrets from Lethal 1918 and H5N1 Influenza Virus Challenge

(2009) L. A. Perrone et al.   JOURNAL OF VIROLOGY

Delivery of Human Immunodeficiency Virus Vaccine Vectors to the Intestine Induces Enhanced Mucosal Cellular Immunity

(2009) L. Wang et al.   JOURNAL OF VIROLOGY

Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses

(2009) Jianhua Sui et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Transient Facial Nerve Paralysis (Bell's Palsy) following Intranasal Delivery of a Genetically Detoxified Mutant of Escherichia coli Heat Labile Toxin

(2009) David J. M. Lewis et al.   PLoS One

Antibody Recognition of a Highly Conserved Influenza Virus Epitope

(2009) D. C. Ekiert et al.   SCIENCE

The role of CD40 and CD154/CD40L in dendritic cells

(2009) Daphne Y. Ma et al.   SEMINARS IN IMMUNOLOGY

Vaccination focusing immunity on conserved antigens protects mice and ferrets against virulent H1N1 and H5N1 influenza A viruses

(2009) Graeme E. Price et al.   VACCINE

International epidemiology of human pre-existing adenovirus (Ad) type-5, type-6, type-26 and type-36 neutralizing antibodies: Correlates of high Ad5 titers and implications for potential HIV vaccine trials

(2009) T. Christopher Mast et al.   VACCINE

Mucosal immunity induced by adenovirus-based H5N1 HPAI vaccine confers protection against a lethal H5N2 avian influenza virus challenge

(2009) Ki Seok Park et al.   VIROLOGY

Therapeutic potential of a fully human monoclonal antibody against influenza A virus M2 protein

(2008) R WANG et al.   ANTIVIRAL RESEARCH

HLA class I supertypes: a revised and updated classification

(2008) John Sidney et al.   BMC IMMUNOLOGY

The curation guidelines of the immune epitope database and analysis resource

(2008) R. Vita et al.   CYTOMETRY PART A

Adenoviruses: update on structure and function

(2008) W. C. Russell   JOURNAL OF GENERAL VIROLOGY

A Broadly Protective Vaccine against Globally Dispersed Clade 1 and Clade 2 H5N1 Influenza Viruses

(2008) Mary A. Hoelscher et al.   JOURNAL OF INFECTIOUS DISEASES

Immunomic Analysis of the Repertoire of T-Cell Specificities for Influenza A Virus in Humans

(2008) E. Assarsson et al.   JOURNAL OF VIROLOGY

Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial

(2008) Susan P Buchbinder et al.   LANCET

A Critical Role for Type I IFN–dependent NK Cell Activation in Innate Immune Elimination of Adenoviral Vectors In Vivo

(2008) Jiangao Zhu et al.   MOLECULAR THERAPY

Bovine Adenoviral Vector–based H5N1 Influenza Vaccine Overcomes Exceptionally High Levels of Pre-existing Immunity Against Human Adenovirus

(2008) Neetu Singh et al.   MOLECULAR THERAPY

Heterosubtypic Neutralizing Monoclonal Antibodies Cross-Protective against H5N1 and H1N1 Recovered from Human IgM+ Memory B Cells

(2008) Mark Throsby et al.   PLoS One

Nasal Delivery of an Adenovirus-Based Vaccine Bypasses Pre-Existing Immunity to the Vaccine Carrier and Improves the Immune Response in Mice

(2008) Maria A. Croyle et al.   PLoS One

Comparison of vaccines for induction of heterosubtypic immunity to influenza A virus: Cold-adapted vaccine versus DNA prime-adenovirus boost strategies

(2008) Chia-Yun Lo et al.   VACCINE

Multi-antigen vaccines based on complex adenovirus vectors induce protective immune responses against H5N1 avian influenza viruses

(2008) David H. Holman et al.   VACCINE

Adenovirus vector induced innate immune responses: Impact upon efficacy and toxicity in gene therapy and vaccine applications

(2007) Zachary C. Hartman et al.   VIRUS RESEARCH