Article
Chemistry, Physical
M. Sarkar, A. Nath, A. Kumer, C. Mallik, F. Akter, Md Moniruzzaman, Md A. Ali
Summary: A synthesized compound was evaluated for antimicrobial activity and the results suggest its potential as an antimicrobial agent. Experimental and computational methods were used to confirm the structure and assess the bioactivity of the compound and its derivatives.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Physical
Yassine Riadi, Oussama Ouerghi, Mohammed H. Geesi, Abdellah Kaiba, El Hassane Anouar, Philippe Guionneau
Summary: In this study, new benzoxazole-linked pyrrolidinone heterocyclic compounds were synthesized using an eco-efficient strategy with a metal-free deep eutectic solvent. The DES, prepared with a eutectic mixture of urea and a synthesized glycine-derived ionic liquid, showed advantages of high productivity, short reaction time, and easy separation for recycling.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Physical
Edward Tatenda Marondedze, Muhammad Mohsin Azim, Bice S. Martincigh, Annegret Stark
Summary: In this study, a binary system of IL-OH and IL-Ester ionic liquids (ILs) was prepared and characterized. The physico-chemical properties such as density, viscosity, thermal stability, and refractive index were determined for the binary system. The addition of IL-Ester increased the viscosity and refractive index, while decreasing the density and thermal stability. The study also provided insights into the mixing behavior and interactions among these binary mixtures.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Organic
Reem A. K. Al-Harbi, Raneem F. N. Albadrani, Samir Y. Abbas
Summary: Due to the importance of quinazolinones and fluorinated compounds, new derivatives of 2-trifluoromethyl-4(3H)-quinazolinone were synthesized. The reaction results showed the formation of various quinazolinone derivatives through different reactions. The structures of the synthesized compounds were confirmed through NMR, mass spectra, and elemental analyses.
JOURNAL OF HETEROCYCLIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Andres-Felipe Villamizar-Mogotocoro, Sandra-Milena Bonilla-Castaneda, Vladimir V. Kouznetsov
Summary: An ecofriendly and efficient method for the synthesis of new pharmacologically active 6-arylphenanthridines has been developed using inexpensive starting materials and consecutive reactions under microwave assistance and a catalytic system, resulting in moderate to excellent yields.
Article
Chemistry, Physical
Jiaqi Wu, Lei Zhang, Jinxing Long, Qiang Zeng, Biaolin Yin, Xuehui Li
Summary: This study presents the design and synthesis of four novel fluorescent ionic liquids through a simple reaction process. The synthesized ionic liquids were extensively characterized and their photophysical properties were determined. The results reveal that these ionic liquids exhibit dual or triple emissions, large stokes shift, and mechanochromic behaviors.
GREEN ENERGY & ENVIRONMENT
(2022)
Article
Biochemistry & Molecular Biology
Fengxi Li, Yaning Xu, Ciduo Wang, Chunyu Wang, Hanqing Xie, Yuelin Xu, Peng Chen, Lei Wang
Summary: An enzymatic method for the synthesis of substituted pyrazoles from readily available diazo compounds and alkynoates/allenoates in ionic liquids was established. The method yielded pyrazoles with different substituents in satisfactory yields (61% - 93%) under the optimum reaction conditions. This method offers a diverse range of substituents in the pyrazole products and a simple workup.
PROCESS BIOCHEMISTRY
(2023)
Article
Chemistry, Applied
Xuejing Liu, Yaoyao Zhang, Shangde Sun
Summary: In this study, a binuclear ionic liquid was synthesized and characterized. Its physicochemical properties were analyzed. It showed excellent catalytic performance and reusability in the esterification reaction of caffeic acid.
Article
Chemistry, Organic
Hongyi Zhao, Yanan Wu, Dongfeng Zhang, Haihong Huang
Summary: In this study, we developed a mild, metal-free method for synthesizing 2-substituted quinazolinones in good to excellent yields (50%-99%) using 2,2,2-trichloroethyl imidates hydrochloride as the organic synthon from methyl 2-aminobenzoates or 2-aminobenzamides. A cheap, readily available base (NaOAc) was utilized for this transformation. The reaction exhibits a broad substrate scope and can be performed on a gram scale.
Article
Chemistry, Physical
Qingtao Zeng, Yonghai Hui, Yuting Wang, Keshu Wen, Jiangchi Huang, Yongfei Zhang, Yun Wang, Shiqi Zhang
Summary: A green and efficient alkali protease lipase-ionic liquids system was used to catalyze the Gewald reaction, resulting in the synthesis of a series of 3-substituted 2-aminothiophenes with moderate to good yields. The catalytic system exhibited good recycling stability.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Inorganic & Nuclear
Li Zhao, Shuliang Chen, Xianzhi Hu, Futing Zi
Summary: Gold adsorption from thiosulfate solution using azole-functionalized microspheres (PS-3-AT) was studied. PS-3-AT effectively adsorbed Au(i)-thiosulfate complex with an adsorption capacity of 39.8 kg/t. Adsorption kinetics and isotherm studies showed that the adsorption process was exothermic and could be described by the pseudo-second-order and Freundlich models. Characterization techniques demonstrated the formation of -NH+Cl- group during the grafting process, and interaction between PS-3-AT and Au(S2O3)(2)(3-) at an atomic level was visualized. PS-3-AT could be regenerated and maintained satisfactory performance after five cycles. The facile synthetic method and adsorption properties of PS-3-AT have significant implications for thiosulfate gold leaching technologies.
DALTON TRANSACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Janez Mravljak, Lara Slavec, Martina Hrast, Matej Sova
Summary: Quinazolinones display diverse biological activities in medicinal chemistry. The study synthesized two series of 2-substituted quinazolin-4(3H)-ones and evaluated their antioxidant properties using three methods. The presence of hydroxyl groups or an ethylene linker enhanced antioxidant activity and led to metal-chelating properties in some derivatives.
Article
Chemistry, Applied
Yunmei Wu, Hui Tan, Liangbin Lin, Hongyu Guo, Fafu Yang
Summary: In this study, Gemini-type fluorescence ionic liquid crystals (ILCs) were prepared and investigated. These ILCs emitted strong fluorescence in aggregated states and exhibited reversible smectic mesophase. The stable gels formed in DMSO-toluene system showed excellent thermal reversible response. The novel ILCs with C6H13 chains presented orderly rectangular columnar stacking in the gel phase.
Article
Biochemistry & Molecular Biology
Yeon Su Kim, Min Gyeong Cheon, Pulla Reddy Boggu, Su Youn Koh, Gi Min Park, Gahee Kim, Seo Hyun Park, Sung Lyea Park, Chi Woo Lee, Jong Woo Kim, Young Hoon Jung
Summary: Phosphatidylinositol 3-kinases (PI3Ks) play a crucial role in cancer treatment. Idelalisib, a drug for hematologic malignancies, had limitations due to adverse effects. New compounds 6f and 6m showed improved enzyme activity and selectivity, potentially offering a promising treatment option.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Antoine Richieu, Philippe Bertrand
Summary: A general microwave synthesis of 4-oxo-3,4-dihydroquinazolin-2-yl propanoic acids and their diamide precursors from the corresponding substituted benzamide and succinic anhydride is described, using pinane as a sustainable solvent that favors the cyclization step. The conditions are some of the most simple and cost effective reported.
Article
Chemistry, Multidisciplinary
Ke Yang, Yi Li, Mengjie Song, Shengfei Dai, Zheng-Yi Li, Xiaoqiang Sun
Summary: The metal-free direct alpha-C(sp(3))-H intramolecular cyclization of 2-alkylthiobenzoic acid in the presence of Selectfluor provides a facile and efficient method to access important 1,3-benzooxathiin-4-one derivatives with good functional groups tolerance and yields.
CHINESE CHEMICAL LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Yi Li, Qingyue Hu, Feiyang Zhang, Zhengyi Li, Xiaoqiang Sun, Ke Yang
Summary: A metal-free method for the cleavage of C(sp(3))-S bond in beta-alkylthio carbonyl compounds in the presence of Selectfluor has been developed, leading to the formation of C-O bond and construction of beta-alkoxy carbonyl compounds. Mechanistic studies suggest the existence of two different pathways, involving oxidant and thionium ion intermediate, in this process.
Article
Chemistry, Multidisciplinary
Mengjie Song, Qingyue Hu, Zheng-Yi Li, Xiaoqiang Sun, Ke Yang
Summary: The metal-free S-S bond exchange reaction of symmetrical disulfides catalyzed by NFSI is a novel and efficient approach to accessing important unsymmetrical disulfides. This strategy can also be applied in the late-stage functionalization of amino acids, drugs, and natural products. The broad substrate scope, good functional group tolerance, and easy accessibility of the catalyst make this strategy a green and practical complementary method for synthesizing various unsymmetrical disulfides.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Yao Wu, Zhiyan Ma, Jing Shi, Xiaoqiang Sun, Ke Yang, Zheng-Yi Li
Summary: A Pd-catalyzed C(sp(3))-H functionalization reaction assisted by a calix[4]arene ligand has been developed for the direct beta-C-H arylation of tertiary aliphatic aldehydes. This strategy shows good functional group compatibility and C-H bond site-selectivity. Mechanistic studies suggest that both synergistic effect and cationic-pi supramolecular interaction between the calixarene cavity and transition-metal catalytic center may play important roles in this catalytic cycle. This complementary method is expected to have applications in organic and medical chemistry.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Organic
Jing Shi, Li-Zhu Zhang, Yong Pan, Deng-Qiang Feng, Guang-Yu Wu, Ke Yang, Xiao-Qiang Sun, Zheng-Yi Li
Summary: A series of indole-based organocatalysts have been designed and synthesized for the three-component direct Mannich reaction of aromatic aldehydes and aromatic amines with ketones. Among them, organocatalyst 2a exhibited excellent catalytic stereoselectivity and high yields under solvent-free conditions at room temperature. The structure of organocatalyst 2a with an eight-membered central ring and interesting strained quadricyclic ring connectivity, along with the hydrogen-bonding interaction, favored the formation of anti-stereoselective product.
TETRAHEDRON LETTERS
(2022)
Review
Chemistry, Physical
Ke Yang, Zhi Li, Qingyue Hu, Mazen Elsaid, Chong Liu, Jun Chen, Haibo Ge
Summary: This review introduces nickel-catalyzed intramolecular and intermolecular pathways for N-heterocycle synthesis from 2008 to 2021.
Article
Chemistry, Organic
Ke Yang, Qingyue Hu, Qin Li, Junxiang Liu, Zheng-Yi Li, Bijin Li, Xiaoqiang Sun
Summary: A metal-free and N-bromosuccinimide (NBS)-mediated direct thiol-disulfide exchange reaction at room temperature has been developed, which allows for the preparation of various unsymmetrical disulfides with good to excellent yields. The efficient late-stage modification of amino acids and drugs demonstrates the practicality of this strategy. Furthermore, the ease of operation, broad substrate scope, and good functional group tolerance make this reaction an essential complementary route to access unsymmetrical disulfides.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Ke Yang, Yanqi Luo, Qingyue Hu, Mengjie Song, Junxiang Liu, Zhengyi Li, Bijin Li, Xiaoqiang Sun
Summary: The selective C(sp(3))-S bond cleavage method was developed to prepare unsymmetrical disulfides. Different reagents and conditions were used to achieve selective cleavage of different types of thioethers, resulting in high yields of unsymmetrical disulfides.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Ke Yang, Qin Li, Zhengyi Li, Xiaoqiang Sun
Summary: The activation and transformation of organic chemical bonds, specifically C-S bond cleavage, has been a major focus in organic chemistry. While transition metal strategies have made significant progress, novel transition-metal-free strategies using halogenated reagents, oxidants, acids, bases, and organic photochemical and electrochemical methods have also been developed. However, a comprehensive review of transition-metal-free strategies has not been reported. This review provides a comprehensive overview of the major advances in transition-metal-free C-S bond cleavage and transformation of organosulfur compounds.
CHEMICAL COMMUNICATIONS
(2023)
Review
Chemistry, Multidisciplinary
Long Tang, Qingyue Hu, Ke Yang, Mazen Elsaid, Chong Liu, Haibo Ge
Summary: Thioether skeletons are widely found in drugs, natural products, functional materials, and life science. In recent years, selective C-H functionalization of thioethers has been extensively studied to create novel thioether derivatives. This mini-review systematically introduces the recent advances in the direct α-C(sp3)-H functionalization of thioethers.
GREEN SYNTHESIS AND CATALYSIS
(2022)
Article
Chemistry, Organic
Shengfei Dai, Ke Yang, Yanqi Luo, Ziyuan Xu, Zhi Li, Zhengyi Li, Bijin Li, Xiaoqiang Sun
Summary: Diverse transformations using Selectfluor as a catalyst have been developed for the synthesis of 2,3-dihydrobenzothiazin-4-ones, benzoisothiazol-3-ones and 2-alkylthiobenzonitriles. The selective cleavage of C-S and C-H bonds can be controlled by different reaction conditions. Notably, this study demonstrates the first example of using Selectfluor as a source to construct 2,3-dihydrobenzothiazin-4-ones.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Multidisciplinary
Ke Yang, Zhi Li, Chong Liu, Yunjian Li, Qingyue Hu, Mazen Elsaid, Bijin Li, Jayabrata Das, Yanfeng Dang, Debabrata Maiti, Haibo Ge
Summary: The transient directing group strategy enables direct β-C(sp(3))-H functionalization of unmasked aliphatic aldehydes. In this study, a direct Pd-catalyzed methylene β-C-H arylation reaction was developed using 3-amino-3-methylbutanoic acid as a transient directing group and 2-pyridone as an external ligand.
Review
Chemistry, Multidisciplinary
Xiao-Qing Feng, He-Cheng Wang, Zhi Li, Long Tang, Xiaoqiang Sun, Ke Yang
Summary: This review systematically introduces the major advances and mechanisms in the field of transition-metal-catalyzed remote C-H functionalization of thioethers from 2010 to 2021.
Review
Chemistry, Organic
Zhiyan Ma, Yunjian Li, Xiao-Qiang Sun, Ke Yang, Zheng-Yi Li
Summary: In recent years, transition metal catalyzed reactions have become one of the most effective methods in organic chemistry, and the research progress of calixarene as a ligand for different transition-metal catalysts and their application in various transition metal catalytic reactions have shown significant breakthroughs.
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Ke Yang, Shengfei Dai, Zhi Li, Zhengyi Li, Xiaoqiang Sun
Summary: The direct acyloxylation of 2-(alkylthio)benzamide has been achieved via an amide-assisted alpha-C(sp(3))-H functionalization in the presence of Selectfluor using simple carboxylic acid and its corresponding salt as acyloxy sources. This method demonstrates a broad substrate scope, moderate to good yields, excellent functional group compatibility, and provides a complementary strategy for accessing important alpha-acyloxy sulfides and their derivatives.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Organic
Dilek Isik Tasgin, Irem Bayraktar
Summary: We present a synthetic method for pyrrolizine-3-one derivatives and investigate their photophysical properties. These compounds are prepared through a series of reactions involving substituted pyrroles in one-pot, two-step oxidation, and intramolecular cyclization processes. The photophysical properties of the synthesized compounds are studied using UV-Vis and fluorescence spectroscopy in various solvents. The introduction of pyrrolyl substituents has a significant impact on Stokes shifts and quantum yield values.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Organic
Satish Kumar Burra, Vaikunta Rao Lakinani, Raghunadh Akula, Chiranjeevi Yankkanti
Summary: A novel and green strategy for the construction of biologically relevant substituted indolyl-4H-chromenes scaffolds is reported, using L-proline as a catalyst and water as a promoter solvent. This catalytic system offers wider applicability, shorter reaction times, and high yields, making it an ideal condition for green chemistry.
SYNTHETIC COMMUNICATIONS
(2024)
Review
Chemistry, Organic
Abouelhaoul El Alami, Amine El Maraghi, Fatima Youssoufi, Assiya Atif, Hamid Sdassi
Summary: Nitrobenzimidazoles have become increasingly important in the design of new compounds in medicinal, therapeutic and chemical fields. This review provides an overview of the synthesis strategies and biological activities of nitrobenzimidazole derivatives.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Organic
Nilesh Raghunath Khedkar, Alex Joseph, Milind Sindkhedkar
Summary: In this study, a new library of 3-(2-(pyrimidin-5-yl)thiazol-4-yl)-1,2,4-oxadiazole compounds was designed and synthesized as potential anticancer agents using in silico fragment-based drug design. The compounds were tested for their anticancer activity in vitro, and one compound exhibited excellent activity against multiple cancer cell lines.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Organic
Terungwa H. Iorkula, Bryce A. Tolman, Scott R. Burt, Matt A. Peterson
Summary: A new method for synthesizing C-6 substituted products has been discovered in this study, which utilizes lower doses of fluoride and CsF as a catalyst, with high reaction yields and cost-effectiveness under suitable conditions.
SYNTHETIC COMMUNICATIONS
(2024)
Review
Chemistry, Organic
Ranjana Aggarwal, Swati Sharma
Summary: This review article mainly focuses on the synthesis of 3(5)-trifluoromethylpyrazoles via condensation reaction of trifluoromethyl-beta-diketones with hydrazines. It emphasizes the importance of fluorine-containing compounds and pyrazoles in the field of biology. The literature reported condensation reactions of trifluoromethyl-beta-diketones with hydrazines are covered.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Organic
F. M. Alshareef, Sami A. Al-Harbi, Esam S. Allehyani, Omeima Abdullah, Magdy A. Ibrahim
Summary: This study aimed to construct a novel category of linear annulated chromeno[3',2':5,6]pyrido[2,3-d][1,3]thiazolo[3,2-a]pyrimidines. The chemical reactivity of the synthesized compounds was investigated, and they showed significant antimicrobial activity against various strains.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Organic
Preethi Dhanapal, S. L. Manju
Summary: Thiazole based Schiff base scaffolds have become an integral part of drug development in recent years, playing a versatile role as building blocks for lead drug molecules. This study presents a facile one pot synthetic method for producing novel 4-aryl thiazoles with high yield, shorter reaction time, and milder conditions, without the need for catalysts or purification techniques.
SYNTHETIC COMMUNICATIONS
(2024)
