Journal
SYNTHETIC COMMUNICATIONS
Volume 41, Issue 13, Pages 1969-1976Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00397911.2010.494814
Keywords
Aldehydes; 1; 4-dihydropyridines; Hantzsch reaction; -keto ester; thiamine hydrochloride (VB1)
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Funding
- Chinese National Science and Technology [2009ZX09301-001, 2009ZX09102]
- Chinese National High-Tech RD Program [2007AA02Z147]
- National Natural Science Foundation of China [90713046, 30772638, 30925040]
- CAS Foundation [KSCX2-YW-R-179]
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[image omitted] An efficient one-pot synthesis of 1,4-dihydropyridines from an aldehyde, -keto ester, and ammonium acetate or formamidine acetate using thiamine hydrochloride (VB1) as the catalyst under solvent-free conditions at ambient temperature is described. All types of aldehydes, including aromatic, aliphatic, and unsaturated aldehydes, give good yields. The catalyst can easily be recovered after completion of the reaction and reused without affecting its activity.
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