Journal
SYNTHETIC COMMUNICATIONS
Volume 40, Issue 13, Pages 2014-2017Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00397910903219443
Keywords
Aldehyde; amide; hydrogen peroxide; nitrile; tandem reaction
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Funding
- Research Corporation
- University of Chattanooga Foundation
- Grote Chemistry Fund
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A facile one-pot synthesis of amides from aldehydes has been developed. This tandem process involves the formation of a nitrile intermediate obtained from the reaction of an aldehyde with hydroxylamine hydrochloride in dimethylsulfoxide at 100 degrees C and the subsequent treatment of the nitrile with basic hydrogen peroxide. The resulting amide products were produced in good yields (67-95%) and purity (95%).
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