4.3 Article

Indolizine Studies, Part 5: Indolizine-2-carboxamides as Potential HIV-1 Protease Inhibitors[1]

Journal

SYNTHETIC COMMUNICATIONS
Volume 40, Issue 13, Pages 2018-2028

Publisher

TAYLOR & FRANCIS INC
DOI: 10.1080/00397910903219450

Keywords

Baylis-Hillman reaction; HIV-1 protease inhibitors; indolizine-2-carboxamides

Funding

  1. National Research Foundation [GUN 2069255]
  2. Medical Research Council of South Africa
  3. Rhodes University

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1,1-Carbonyldiimidazole-promoted coupling of Baylis-Hillman-derived indolizine-2-carboxylic acids with a range of amine and amino acid derivatives has provided access to the corresponding carboxamides in moderate to excellent yield.

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