4.3 Article

Synthesis of 2-Arylquinazolin-4(3H)-one Derivatives Catalyzed by Iodine in [bmim(+)][(BF-)(4)]

Journal

SYNTHETIC COMMUNICATIONS
Volume 40, Issue 17, Pages 2633-2646

Publisher

TAYLOR & FRANCIS INC
DOI: 10.1080/00397910903318609

Keywords

2-Aminobenzamide; ionic liquid; quinazolin-4(1H)-one; synthesis

Funding

  1. National Natural Science Foundation of China [20802061]
  2. Natural Science Foundation [08KJD150019]
  3. Jiangsu Education Committee [08QLT001]

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Controlling selectivity of the reactions of aromatic aldehydes and 2-aminobenzamide in ionic liquid catalyzed by iodine at either room temperature or at 80 degrees C under nitrogen resulted in the synthesis of (E)-Schiff bases, 2,3-dihydro-2-arylquinazolin-4(1H)-one and 2-arylquinazolin-4(3H)-one derivatives, in excellent yields.

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