4.3 Article

A Facile One-Pot Conversion of Aldehydes into Nitriles

Journal

SYNTHETIC COMMUNICATIONS
Volume 39, Issue 20, Pages 3601-3606

Publisher

TAYLOR & FRANCIS INC
DOI: 10.1080/00397910902788174

Keywords

Aldehyde; aldoxime; dehydration; nitrile; tandem reaction

Funding

  1. Research Corporation
  2. University of Chattanooga Foundation
  3. Grote Chemistry Fund

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A facile one-pot synthesis of nitriles starting with aldehydes has been developed employing hydroxylamine hydrochloride in dimethylsulfoxide at 100 degrees C.

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