Journal
SYNTHETIC COMMUNICATIONS
Volume 39, Issue 1, Pages 102-110Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00397910802369661
Keywords
Aerobic oxidation; ceric ammonium nitrate (CAN); tandem oxidation process (TOP); three-component reaction; trisubstituted imidazole
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Funding
- Research Council of Shahid Beheshti University
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By combining a ceric ammonium nitrate (CAN)-catalyzed aerobic oxidation of alpha-hydroxy ketones with a subsequent three-component condensation reaction using aldehydes and ammonium acetate, highly substituted imidazole derivatives can be assembled. This reaction is an important approach for the synthesis of highly substituted imidazole derivatives and was carried out in good to excellent yields in ethanol as an environmentally benign solvent.
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