4.3 Article

Mannich-type reaction catalyzed by silica-supported fluoroboric acid under solvent-free conditions

Journal

SYNTHETIC COMMUNICATIONS
Volume 38, Issue 4, Pages 546-552

Publisher

TAYLOR & FRANCIS INC
DOI: 10.1080/00397910701796766

Keywords

aldehyde; amine; HBF4-SiO2; Mannich reaction; silyl enolate

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Three-component Mannich-type reaction of aldehydes, aromatic amines, and silyl enolate proceeded smoothly to afford -amino carbonyl compounds with good yields in the presence of a catalytic amount of HBF4-SiO2.

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