Journal
SYNTHETIC COMMUNICATIONS
Volume 38, Issue 11, Pages 1703-1717Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00397910801982340
Keywords
amination; azetidine; benzhydrol; imidoyl chloride
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A convenient synthesis of structurally novel 1,3-disubstituted azetidine derivatives is described. The approach involves condensation of an azetidine building block with sulfonylated carbamic acid methyl ester, subsequently followed by quenching the imidoyl chloride with amines. Different derivatives were prepared by substituting benzhydrol as well as benzenesulfonamide as part of the core structure.
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