4.3 Article Proceedings Paper

Novel chemoselective reduction of aldehydes in the presence of other carbonyl moieties with thiourea dioxide

Journal

SYNTHETIC COMMUNICATIONS
Volume 38, Issue 13, Pages 2150-2157

Publisher

TAYLOR & FRANCIS INC
DOI: 10.1080/00397910802026220

Keywords

aldehyde; carbonyl; chemoselective; formamidine sulfinic acid; reduction; thiourea dioxide

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Reduction of a variety of aldehydes in the presence of other carbonyl moieties to the corresponding alcohols occurs chemoselectively in high yields upon treatment with inexpensive reagent thiourea dioxide (TUDO) in aqueous alkali-ethanolic system for 2h at 90 degrees C.

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