4.5 Article

An Efficient Synthesis of Azetidines with (2-Bromoethyl)sulfonium Triflate

Journal

SYNTHESIS-STUTTGART
Volume 44, Issue 10, Pages 1584-1590

Publisher

GEORG THIEME VERLAG KG
DOI: 10.1055/s-0031-1290951

Keywords

annulations; cyclizations; heterocycles; sulfur; ylides

Funding

  1. Engineering and Physical Sciences Research Council (EPSRC)
  2. Junta de Andalucia (C.E.I.y C.)
  3. Royal Society
  4. Merck
  5. Engineering and Physical Sciences Research Council [EP/D501725/1, EP/E052185/1] Funding Source: researchfish
  6. EPSRC [EP/E052185/1] Funding Source: UKRI

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Easily accessible arylglycine derivatives were cyclized to azetidines by using commercially available (2-bromoethyl)sulfonium triflate in a simple and mild procedure. The high-yielding reaction has a relatively broad scope and was extended to the synthesis of an oxetane.

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