Journal
SYNTHESIS-STUTTGART
Volume -, Issue 17, Pages 2796-2802Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0030-1260129
Keywords
iridium; asymmetric hydrogenation; electron-deficient ligands; quinolines
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Funding
- National Science Foundation of China [21032003, 20921092]
- National Basic Research Program [2010CB833300]
- Chinese Academy of Sciences
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A series of electronically deficient atropisomeric bisphosphine ligands have been synthesized from (S)-MeO-BiPhep. The introduction of electron-withdrawing groups in the ligands had a dramatic influence on both the enantioselectivity and the activity of catalyst. The iridium complex of the MeO-BiPhep-based ligand bearing a trifluoromethanesulfonyl group was successfully applied in the asymmetric hydrogenation of quinolines with ee values of up to 95% and turnover numbers (TON) of up to 14,600.
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