Journal
SYNTHESIS-STUTTGART
Volume -, Issue 7, Pages 1131-1136Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0028-1088004
Keywords
aza-Henry reaction; isoquinoline/quinoline; activated alkynes; nitromethane
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A three-component coupling (3CC) of isoquinoline, activated alkynes and nitromethane has been achieved for the First time to produce nitromethyl derivatives of dihydroisoquinoline in excellent yields with high selectivity. The reaction proceeds smoothly at 25 degrees C without catalyst.
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