Journal
SYNTHESIS-STUTTGART
Volume -, Issue 19, Pages 3131-3141Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2008-1067273
Keywords
rearrangement; radical reactions; substituent effects; halo compounds; gamma-lactams
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Funding
- Ministero della Universita e della Ricerca Scientifica e Tecnologica (MURST)
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The preparation of the 3,4-dialkyl-substituted maleic anhydride nucleus, through the functional rearrangement of dichloro gamma-lactams, allowed the comparison of various N-substituents in the functional rearrangement step. The 2-pyridyl group proved to be the most appropriate N-substituent for the hydrolysis of the 5-methoxy-1,5-dihydro-2H-pyrrol-2-one intermediate into the 5-hydroxy adduct, and for the hydrolysis of the maleimide nucleus into the maleic anhydride. The oxidation of the 5-hydroxy-1,5-dihydro-2H-pyrrol-2-one into the corresponding maleimide was achieved with manganese(IV) oxide.
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