Journal
SYNTHESIS-STUTTGART
Volume -, Issue 21, Pages 3361-3376Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0028-1083171
Keywords
enantioselective reaction; chiral ligand; Schiff base; asymmetric C-C bond formation; oxazoline
Categories
Funding
- Scientific Research on Priority Areas 'Advanced Molecular Transformations of Carbon Resource'
- Ministry of Education, Culture, Sports, Science and Technology, Japan [817340020]
- JSPS Research Fellowship
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Obtaining both enantiomers of a given compound in high enantiomeric excess is an attractive and important challenge, because it is often the case that each enantiomer exhibits different bioactivity. This review summarizes some approaches to realize complete reversal of enantioselectivity by changing various reaction conditions. Our new approach to achieve reversal of enantioselection in the enantioselective addition of diketene to aldehydes, affording optically active 5-hydroxy-3-keto esters in high optical yield using, Schiff bases that contain an oxazoline moiety derived from L-serine, is also described.
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