Lanthanide Complexes of 1-phenyl-3-methyl-5-hydroxypyrazole-4-carbaldehyde-(4-hydroxybenzoyl) Hydrazone: Crystal Structure and Interaction Studies With Biomacromolecules

1-phenyl-3-methyl-5-hydroxypyrazole-4-carbaldehyde-(4-hyd roxybenzoyl) hydrazone and Ln(III) complexes have been synthesized and characterized. The interaction between these compounds and biomacromolecules was investigated by fluorescence and UV/vis absorption spectroscopy. The results suggested that the compounds caused fluorescence quenching of BSA through a static quenching procedure. Hydrophobic interaction force also played a major role in stabilizing the compounds. Moreover, interactions between calf thymus DNA and compound H3L and its Ln(III) complexes were studied by spectroscopy and viscosity measurements. These studies showed that these compounds bind to DNA via an intercalation mode. Furthermore, antioxidant activities of compounds were determined by hydroxyl radical scavenging methods in detail. Supplemental materials are available for this article. Go to the publisher's online edition of Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry to view the supplemental file.