Review
Chemistry, Multidisciplinary
Jian-Xing Xu, Le-Cheng Wang, Xiao-Feng Wu
Summary: Carbonylative multi-component reactions (CMCR) are an efficient strategy for the preparation of polyfunctional carbonylated compounds, using four or more starting materials. Diverse CMCR utilizing non-noble transition-metal catalysts have been developed. This review summarized and discussed the recent advances in non-noble metal-catalyzed carbonylative multi-component reactions.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Review
Chemistry, Multidisciplinary
Takanori Iwasaki, Nobuaki Kambe
Summary: Carbon-fluorine bonds are stable but can be selectively transformed under appropriate conditions, making them useful synthetic methods in organic chemistry. This review focuses on C-C bond formation at monofluorinated sp(3)-hybridized carbons via C-F bond cleavage, including cross-coupling and multi-component coupling reactions. The mechanisms of C-F bond cleavage on sp(3)-hybridized carbon centers are categorized into three types: Lewis acids promoted F atom elimination, nucleophilic substitution with metal or carbon nucleophiles, and cleavage of C-F bonds via single electron transfer. Furthermore, the unique characteristics of alkyl fluorides compared to other (pseudo)halides as electrophilic coupling counterparts are discussed.
Review
Chemistry, Multidisciplinary
Siew Ping Teong, Yugen Zhang
Summary: Covalent organic frameworks (COFs) and metal organic frameworks (MOFs) are crystalline porous materials with ordered framework structures. Researchers are exploring new synthesis methods, building blocks, and processing/fabrication protocols to meet the demands for continuous pore size control and property development. Multi-component or multiple ligands synthesis has been widely used in the construction of MOF structures, and recently adopted for COF synthesis and extended to versatile linker designing strategies.
Article
Environmental Sciences
Yike Zhou, Sunling Gong, Chunhong Zhou, Lei Zhang, Jianjun He, Yuesi Wang, Dongsheng Ji, Jianing Feng, Jingyue Mo, Huabing Ke
Summary: This study developed a new parameterization scheme for heterogeneous reactions on multi-component aerosols, successfully applied to simulate sulfate mass concentrations in the Beijing-Tianjin-Hebei region. The results showed good agreement between simulations and observations, highlighting the role of aerosol chemical components in sulfate formation.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Review
Chemistry, Organic
Vishal B. Purohit, Ronak V. Prajapati, Vaibhav D. Prajapati, Sharad C. Karad, Nirav H. Sapariya, Jemin R. Avalani, Dipak K. Raval
Summary: This contribution provides a comprehensive overview of the C-H activation/functionalization reactions of 1-aryl-5-pyrazolones, specifically focusing on edaravones and their N-methyl analogues. It summarizes the recent progress in C-H functionalization reactions of these compounds under transition-metal-catalyzed/free conditions and discusses the related mechanism based on the role of the catalytic species.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Jingjing Jiang, Yves Queneau, Florence Popowycz
Summary: The use of the renewable platform molecule 5-HMF in multi-component reaction with a diamine and an alkynone to generate seven-membered 1,5-benzodiazepines is described. Ammonium acetate in ethanol proved to be a clean and efficient system among catalysts/solvents couples. The optimized conditions were used to investigate the scope of the reaction providing a library of 1,5-benzodiazepines in moderate to good yields from a wide range of diversely substituted diamines and alkynones or alkyl alkynoates.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Ziwei Luo, Junhao Ding, Dayun Huang, Xiangmei Wu, Yicheng Bi
Summary: This article provides a comprehensive overview of the applications of H-phosphonates, H-phosphinates, and secondary phosphine oxides in organic synthetic chemistry. The advancements made in three-component reactions using these reagents are discussed, specifically focusing on their reactions with bicyclo[1.1.1]pentane, alkenes, alkynes, aldehydes, imines, S, Se, etc. The mechanisms of these reactions are also explored.
TETRAHEDRON LETTERS
(2022)
Article
Chemistry, Physical
G. Shanker, M. K. Srinatha, D. Sandhya Kumari, B. S. Ranjitha, M. Alaasar
Summary: This paper reports the synthesis of disk-shape liquid crystalline materials using multi-component reactions. Two new series of compounds were successfully synthesized and characterized. The synthetic approach provides multiple advantages and could pave a new way in the synthesis of liquid crystalline compounds.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Applied
Fathali Gholami Orimi, Behrooz Mirza, Zinatossadat Hossaini
Summary: In this research, imidazole derivatives were synthesized in high yields using a five component reaction in water at room temperature, with Fe3O4/ZnO/MWCNTs nanocomposites as catalyst. The synthesized compounds showed significant antioxidant and antimicrobial activity, demonstrating the effectiveness of the process.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Zahra Karimi, Shirin Rahmani, Bita Farhadi, Shokoufeh Heydaripour, Mohammad Omidi
Summary: We have developed a green and efficient method for the synthesis of 4-arylidene-1-(4-phenylselenazol-2-yl)-3-methyl-1H-pyrazole-5(4H)-ones. This method involves the condensation of phenacyl bromide, selenosemicarbazide, ethyl acetoacetate, and aryl aldehyde in acetic acid with sodium acetate as a base.
POLYCYCLIC AROMATIC COMPOUNDS
(2023)
Article
Materials Science, Multidisciplinary
Lulu Hu, Fen Zhong, Jun Zhang, Shijun Zhao, Yongqiang Wang, Guangxu Cai, Tao Cheng, Guo Wei, Shuangfeng Jia, Dongxun Zhang, Ran Yin, Zhiquan Chen, Changzhong Jiang, Feng Ren
Summary: Developing ceramic coatings with high hydrogen isotopes permeation resistance is crucial in various fields. In this study, a (TiVAl-CrZr)O multi-component metal oxide glass (MCMOG) coating was developed as a new type of hydrogen isotopes permeation barrier. The diffusion behavior of deuterium in MCMOG was investigated, and the results showed that MCMOG has significantly suppressed deuterium permeation due to its rugged energy landscape induced by the diversity of electronic band structures. Oxygen vacancies also strongly affect the permeation reduction factor (PRF) of MCMOG.
Review
Chemistry, Organic
Dhruba Jyoti Boruah, Lodsna Borkotoky, Uma Devi Newar, Ram Awatar Maurya, Panneerselvam Yuvaraj
Summary: Multicomponent reactions (MCRs) are powerful tools in synthetic chemistry for efficiently synthesizing diverse molecular scaffolds, particularly nitrogen-containing heterocycles. However, the use of transition metal catalysts or additives in MCRs can have limitations due to cost, toxicity, and environmental concerns. This review focuses on recent advancements in transition metal-free MCRs for synthesizing valuable N-heterocyclic compounds and highlights their potential as sustainable and efficient strategies for accessing nitrogen-containing heterocycles.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Ahmad Shaabani, Reza Mohammadian, Ronak Afshari, Seyyed Emad Hooshmand, Mohammad Taghi Nazeri, Siamak Javanbakht
Summary: Isocyanides are widely used in organic reactions to synthesize diverse organic compounds, drawing attention from chemists worldwide. Iranian scientists have significantly contributed to the development of isocyanides chemistry, introducing new synthetic routes and reactions involving isocyanides. The applications of isocyanides in the synthesis of pharmaceuticals and industrially important compounds, as well as the development of innovative catalytic systems, have been highlighted in recent literature reviews.
MOLECULAR DIVERSITY
(2021)
Article
Chemistry, Organic
Hui Xu, Hong Chen, Xiao Hu, Guang Xuan, Pinhua Li, Ze Zhang
Summary: An iodine-promoted domino reaction method has been discovered, which allows for the efficient synthesis of a variety of 1,2,4-trisubstituted 5-(o-hydroxybenzoyl)imidazoles. The reaction proceeds in a consecutive manner, involving Michael addition, iodination, cyclization from intramolecular nucleophilic substitution, and dehydrogenative aromatization from spiro ring opening.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Ryunosuke Kani, Toshiyasu Inuzuka, Yasuhiro Kubota, Kazumasa Funabiki
Summary: We have developed a functional-group-tolerant one-pot method for synthesizing various 3-substituted 1-trifluoromethylpropargyl alcohols. This method involves three successive reactions and can be applied to different fluorine-containing esters and terminal alkynes. The obtained products can be further transformed into important compounds for the treatment of pain and inflammation associated with osteoarthritis in dogs.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Naimat Kalim Bari, Gaurav Kumar, Aashish Bhatt, Jagadish Prasad Hazra, Ankush Garg, Md. Ehesan Ali, Sharmistha Sinha
Article
Biochemistry & Molecular Biology
Jagadish P. Hazra, Amin Sagar, Nisha Arora, Debadutta Deb, Simerpreet Kaur, Sabyasachi Rakshit
BIOCHEMICAL JOURNAL
(2019)
Article
Chemistry, Physical
Satavisha Sarkar, Arghya Banerjee, Wang Yao, Eric V. Patterson, Ming-Yu Ngai
Article
Biophysics
Ankush Garg, Jagadish Prasad Hazra, Malay Kumar Sannigrahi, Sabyasachi Rakshit, Sharmistha Sinha
BIOPHYSICAL JOURNAL
(2020)
Article
Biochemistry & Molecular Biology
Gayathri S. Singaraju, Amin Sagar, Anuj Kumar, Jesse S. Samuel, Jagadish P. Hazra, Malay K. Sannigrahi, Ragothaman M. Yennamalli, Ashish, Sabyasachi Rakshit
Article
Chemistry, Organic
Abdur Rahim, Biswajit Sahariah, Kalpita Baruah, Jugal Kishore Rai Deka, Bani Kanta Sarma
JOURNAL OF ORGANIC CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Naimat K. Bari, Jagadish P. Hazra, Gaurav Kumar, Simerpreet Kaur, Sharmistha Sinha
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2020)
Article
Chemistry, Organic
Jugal Kishore Rai Deka, Biswajit Sahariah, Sushil S. Sakpal, Arun Kumar Bar, Sayan Bagchi, Bani Kanta Sarma
Summary: 1,2-Dibenzoyl-1-tert-butylhydrazine and related N-alkyl-N,N'-diacylhydrazines are environmentally friendly insect growth regulators. The interactions mediated by a hydrazide amide nitrogen atom play a crucial role in stabilizing their biologically active trans-cis rotameric conformations, as supported by spectroscopic and computational studies.
Article
Chemistry, Organic
Kalpita Baruah, Biswajit Sahariah, Sushil S. Sakpal, Jugal Kishore Rai Deka, Arun Kumar Bar, Sayan Bagchi, Bani Kanta Sarma
Summary: Experimental evidence has confirmed the presence of N-amide···H-Namide hydrogen bonds in azapeptides, which provide stabilization effects. These hydrogen bonds enforce specific amide bond conformations in azapeptides and N-methyl-azapeptides.
Article
Biology
Nisha Arora, Jagadish Prasad Hazra, Sabyasachi Rakshit
Summary: Proteins, including individual ones and complexes, play important roles as force-sensors in responding to mechanical cues. Research suggests that protein complexes exhibit distinct mechanical responses to force compared to individual force-sensors.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Gaurav Kumar, Naimat K. Bari, Jagadish P. Hazra, Sharmistha Sinha
Summary: The bacterial microcompartment is a prokaryotic organelle that confines enzymes in a small volume enveloped by an outer protein shell. This study found that the major shell protein PduBB' preserves the catalytic activity and stability of enzymes within the microcompartment, preventing unfolding and aggregation under thermal stress.
Article
Chemistry, Multidisciplinary
Kalpita Baruah, Debajit Kalita, Biswajit Sahariah, Jugal Kishore Rai Deka, Pratap Vishnoi, Bani Kanta Sarma
Summary: From X-ray, NMR, and DFT studies of azapeptoids, a tetrel bonding interaction that stabilizes trans-peptoids has been discovered. Peptoids with alpha-heteroatoms and N-aryl groups in the sidechain adopt trans-amide geometries due to the tetrel bonding interaction between the sidechain alpha-heteroatom lone pair or pi-electrons and the sigma* orbital of the backbone C-alpha-N bond. CD spectroscopic studies of oligo-proline host-guest model peptides also showed that azapeptoid residues stabilize polyproline II helical conformation.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Jugal Kishore Rai Deka, Debashree Borah, Paramesh Das, Biswajit Sahariah, Pratap Vishnoi, Bani Kanta Sarma
Summary: Carbonyl-carbonyl (COMIDLINE HORIZONTAL ELLIPSISCO) n -> pi* interaction often coexists with a hydrogen bond or another n -> pi* interaction. In this study, a set of proline-diacylhydrazine molecules were investigated, and it was found that the increase in the strength of the n(N) -> pi*(Ar) interaction on the DAH side strengthened the n -> pi* interaction on the Pro side. This research provides a simple C-terminal modification strategy to stabilize the trans-Pro geometry, which is important for stabilizing PPII helices and collagen triple helices.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Jugal Kishore Rai Deka, Biswajit Sahariah, Kalpita Baruah, Arun Kumar Bar, Bani Kanta Sarma
CHEMICAL COMMUNICATIONS
(2020)
Article
Materials Science, Biomaterials
Naimat K. Bari, Gaurav Kumar, Jagadish P. Hazra, Simerpreet Kaur, Sharmistha Sinha
JOURNAL OF MATERIALS CHEMISTRY B
(2020)
