Review
Neurosciences
Jia Liu, Yakun Gu, Mengyuan Guo, Xunming Ji
Summary: The brain, as the organ with the highest oxygen demand, has poor tolerance to ischemia and hypoxia. Ischemic/hypoxic preconditioning has been studied as an effective strategy to improve tolerance and is considered significant in treating CNS diseases. It involves multiple protective mechanisms and is a research frontier in neurotherapy, with challenges in translating from basic research to clinical application.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Medicine, Research & Experimental
E. Yu Plotnikov
Summary: Ischemic preconditioning, discovered in 1986 with the heart and observed in various organs including the kidneys, is an effective way to prevent acute kidney injury by conditioning tissues with short ischemia/reperfusion cycles. Understanding the molecular mechanisms of kidney ischemic preconditioning is crucial for developing nephroprotective therapy to elevate renal tolerance to oxygen deficiency.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Eva Baranovicova, Petra Hnilicova, Dagmar Kalenska, Peter Kaplan, Maria Kovalska, Zuzana Tatarkova, Anna Tomascova, Jan Lehotsky
Summary: H-1 NMR metabolomics is a valuable tool for characterizing the distribution and alterations of metabolites induced by cerebral ischemic injury or its combination with hyperhomocysteinemia. The study found decreased neurotransmitter pool and increased tissue glutamine level in the brain tissue after ischemic injury. Metabolomic alterations were observed in the blood plasma, including decreased glycolytic intermediates and increased plasma ketone bodies. Ischemic preconditioning showed a lower extent of metabolomic changes. In hyperhomocysteinemic models, a decrease in several amino acids in plasma was associated with hippocampal neuropathology.
Article
Physiology
Caitlin P. Jarrard, Mercedes J. Nagel, Sten Stray-Gundersen, Hirofumi Tanaka, Sophie Lalande
Summary: Ischemic preconditioning and intermittent hypoxia can attenuate the reduction in brachial artery endothelial function caused by ischemia-reperfusion injury in young healthy individuals.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Biology
Min Hu, Joseph M. Santin
Summary: This study investigates the reorganization of the metabolic transcriptional network in the brainstem of American bullfrogs during hibernation to achieve ischemia tolerance. The results suggest that improving neural performance during ischemia involves a transcriptional program for glycogen and glucose metabolism.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Physiology
Lyvia R. Bowering, Tristan J. McArley, Jules B. L. Devaux, Anthony J. R. Hickey, Neill A. Herbert
Summary: This study investigated the impacts of climate change stressors on the Australasian snapper in New Zealand. The results showed that the snapper's metabolic performance remained high even in warm conditions, and they were able to adapt well to hypoxia. Therefore, despite the threat climate change poses to marine organisms, a temperature of 25°C may be metabolically optimal for the Australasian snapper in Northern New Zealand.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
John C. Quindry, Barry A. Franklin
Summary: Exercise preconditioning is a cardioprotective phenotype that confers short-term protection against acute myocardial infarction through various mechanisms. Recent clinical studies confirm the cardioprotective benefits of exercise in humans, suggesting that initiating a remedial exercise regimen can improve clinical outcomes following acute cardiac events.
AMERICAN JOURNAL OF CARDIOLOGY
(2021)
Article
Behavioral Sciences
Rahul Ranjan, Amitabh, Dipti N. Prasad, Ekta Kohli
Summary: The study showed that hypothermic preconditioning can prevent spatial memory deficit and neurodegeneration induced by HH, reduce oxidative stress, and restore hippocampal neuronal structure and spatial memory in rats.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Immunology
Nicholas W. Kieran, Rahul Suresh, Marie-France Dorion, Adam MacDonald, Manon Blain, Dingke Wen, Shih-Chieh Fuh, Fari Ryan, Roberto J. Diaz, Jo Anne Stratton, Samuel K. Ludwin, Joshua A. Sonnen, Jack Antel, Luke M. Healy
Summary: This study investigated the expression levels of miR-210 in astrocytes under ischemic stroke and in vitro stress conditions, and found its association with the astrocytic response to disease and neuroprotection.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Multidisciplinary Sciences
Shrey Dutta, Kartik K. Iyer, Sampsa Vanhatalo, Michael Breakspear, James A. Roberts
Summary: This article presents research on the relationship between brain activity and oxygen supply. The researchers used computational modeling to explore the mechanisms by which oxygen depletion generates pathological brain activity and found that restricting oxygen supply leads to transitions from normal to pathological activity patterns. Trajectories through parameter space track key features of clinical electrophysiology recordings and reveal differences in parameter values between infants with good recovery outcomes and those with poor outcomes.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Shrey Dutta, Kartik K. Iyer, Sampsa Vanhatalo, Michael Breakspear, James A. Roberts
Summary: Disruption to the brain's oxygen supply triggers pathological dynamics and brain injuries. Here, the authors develop a model of coupled metabolic-neuronal activity that generates burst suppression patterns similar to those of infants after birth asphyxia.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Christopher S. Wilson, Blair T. Stocks, Emilee M. Hoopes, Jillian P. Rhoads, Kelsey L. McNew, Amy S. Major, Daniel J. Moore
Summary: The study suggests that targeting glucose and mitochondrial metabolism can enable endogenous immune tolerance mechanisms to respond to tolerance induction in an animal model of lupus, potentially restoring durable immune tolerance and offering a new approach for autoimmune and transplant settings.
Article
Plant Sciences
Isabella Bettarini, Cristina Gonnelli, Federico Selvi, Andrea Coppi, Luigia Pazzagli, Ilaria Colzi
Summary: The study found that nickel has a stimulatory effect on plant growth in Odontarrhena populations, and tolerance is positively correlated with nickel accumulation.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2021)
Article
Biochemistry & Molecular Biology
Changjiang Gu, Fanqi Kong, Junkai Zeng, Xiangwu Geng, Yanqing Sun, Xiongsheng Chen
Summary: Delayed remote ischemic preconditioning (RIPC) has protective effects against spinal cord ischemia-reperfusion injury (SCIRI) in mice, and SIRT3 is involved in this protection through the NMDAR-AMPK-PGC-1 alpha signaling pathway.
CELL AND BIOSCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Juan Manuel Molina, Andreas Kunzmann, Joao Pena Reis, Pedro Miguel Guerreiro
Summary: In this study, the metabolic rates, thermal, and oxygen-related limits of Halobatrachus didactylus were estimated for the first time. The results show that this species is remarkably resilient to acute environmental variations in temperature and oxygen content, which suggests its ability to adapt to future extreme abiotic conditions in the oceans.
Article
Biochemistry & Molecular Biology
Tianxu Han, Chao-Shun Yang, Kung-Yen Chang, Danhua Zhang, Farhad B. Imam, Tariq M. Rana
Article
Obstetrics & Gynecology
Elza Cloete, Malcolm R. Battin, Farhad B. Imam, Rita L. Teele
AMERICAN JOURNAL OF PERINATOLOGY
(2013)
Article
Multidisciplinary Sciences
Nadine L. Vastenhouw, Yong Zhang, Ian G. Woods, Farhad Imam, Aviv Regev, X. Shirley Liu, John Rinn, Alexander F. Schier
Article
Genetics & Heredity
I. G. Woods, F. B. Imam
Article
Biochemistry & Molecular Biology
S Raychaudhuri, JT Chang, F Imam, RB Altman
NUCLEIC ACIDS RESEARCH
(2003)