Journal
SYNLETT
Volume -, Issue 11, Pages 1590-1604Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0031-1290984
Keywords
Michael addition; heterocycles; catalysis; nucleophilic addition; transition metals
Categories
Funding
- National Science Foundation [CHE-0749907]
- NIH-National Institute of General Medical Sciences [GM085736-01A1]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [0749907] Funding Source: National Science Foundation
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Conjugate or Michael addition to vinyl-substituted aromatic N-heterocycles has been a useful synthetic method for the synthesis of functionalized heterocyclic compounds. A wide variety of heterocycles and nucleophiles undergo this chemistry. Recent work in this area has utilized transition-metal catalysts and some asymmetric synthesis has been accomplished. An overview of this chemistry is presented in this account. 1 Introduction 2 General Aspects 3 Carbon-Centered Nucleophiles 4 Nitrogen-Centered Nucleophile 5 Oxygen and Sulfur Nucleophiles 6 Transition-Metal-Catalyzed Reactions 7 Asymmetric Conjugate Addition 8 Summary and Outlook
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