Journal
SYNLETT
Volume -, Issue 17, Pages 2463-2468Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0031-1290467
Keywords
arylation; copper catalysis; aziridine; terminal alkyne; benzyne
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Funding
- Ministero dell'Universita e della Ricerca
- University of Pisa
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Alkenyl aziridines can be successfully arylated in a three-component coupling triggered by in situ generated benzyne with a simple copper catalyst (CuI-PPh3), without the need of any palladium salts. The corresponding allylic amines can be obtained with good to high regioselectivity in mild reaction conditions with a variety of cyclic and acyclic alkenyl aziridines. A new domino reaction with ethyl propiolate to give tetrahydrophenanthridine was also found.
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