Journal
SYNLETT
Volume -, Issue 10, Pages 1399-1402Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0030-1260561
Keywords
diastereoselective; cytoxazone; tyrosine; oxazolidinone; oxidation
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Funding
- Loughborough University
- Research Councils UK
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A three-step protocol for the highly diastereoselective (> 98%) synthesis of both (4R,5R)- and (4S,5S)-isocytoxazone from D-or L-tyrosine is reported. The diastereoselection was confirmed by X-ray crystallography. This synthesis is currently the highest yielding approach towards these enantiomerically pure biologically active oxazolidinones.
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