Journal
SYNLETT
Volume -, Issue 20, Pages 2951-2954Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0031-1290084
Keywords
Lewis acid; aldehydes; 4-(phenylthio)but-3-en-1-ol; tetrahydrofuran scaffolds
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Funding
- CSIR, New Delhi
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Aldehydes undergo smooth cyclization with 4-(phenylthio)but-3-en-1-ol in the presence of BF3 center dot OEt2 in dichloromethane at room temperature to afford a novel class of 2,3-disubstitued tetrahydrofurans in good yields with all-cis-selectivity. This method is simple, selective, and convenient for the synthesis of tetrahydrofuran scaffolds in a single step.
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