First Synthesis of 3-Amino-2-arylimidazo[1,2-b]pyridazines by Groebke-Blackburn Reaction

The Groebke-Blackburn transformation of an 3-aminopyridazine, a benzaldehyde, and an isocyanide allows the onestep assembly of so far unknown 3-amino-2-arylimidazo[1,2-b]pyridazines. Diversely substituted aldehydes and isocyanides can be used for this reliable three-component condensation, delivering biheterocyclic products with a broad range of different substituents in the imidazole moiety.