Journal
SYNLETT
Volume -, Issue 8, Pages 1133-1136Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0030-1259945
Keywords
N-heterocyclic carbenes (NHCs); umpolung; cascade reaction; Stetter reaction; 2-aminofuran
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Funding
- Chinese National Science and Technology Major Project 'Key New Drug Creation and Manufacturing Program' [2009ZX09301-001, 2009ZX09102-022]
- National Natural Science Foundation of China [21002027, 90713046, 30772638, 30925040]
- CAS Foundation [KSCX2-YW-R-179]
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An efficient method for the synthesis of 4,5-disubstituted 2-aminofuran-3-carbonitriles via a cascade Stetter-gamma-ketonitrile cyclization reaction of aromatic aldehydes with acylidenemalononitriles, catalyzed by N-heterocyclic carbenes, has been developed. This procedure provides the corresponding products in moderate to high yields under mild conditions.
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