4.4 Article

Room-Temperature Copper-Catalyzed Synthesis of Primary Arylamines from Aryl Halides and Aqueous Ammonia

Journal

SYNLETT
Volume -, Issue 9, Pages 1355-1358

Publisher

GEORG THIEME VERLAG KG
DOI: 10.1055/s-0029-1219922

Keywords

copper; catalysis; cross-coupling; room temperature; aqueous ammonia; primary arylamine

Funding

  1. Open-end Funds of Jiangsu Key Laboratory of Marine Biotechnology [2009HS02]
  2. Six Kinds of Professional Elite Foundation of Jiangsu Province [07-A-024]
  3. Natural Science Foundation [Z2008024]
  4. Initial Fund of Huaihai Institute of Technology [KQ09030]

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Primary arylamines can be prepared via a copper-catalyzed cross-coupling between aryl halides and aqueous ammonia using K3PO4 as a base and DMF as a solvent at room temperature.

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