Journal
SYNLETT
Volume -, Issue 4, Pages 628-632Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0028-1087915
Keywords
multicomponent reaction; regioselective synthesis; N-heterocycles; zirconium(IV) chloride; polyethylene glycol
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Funding
- DST, New Delhi
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An Ugi-type multicomponent reaction of heterocyclic amidines with aldehydes and isocyanides catalyzed by zirconium(IV)chloride in PEG-400 was developed. The protocol offers the rapid, environment friendly, regioselective and versatile synthesis of medicinally important N-fused 2- and 3-aminoimidazoles in good to high yields. The combination of catalyst and solvent, that was judiciously explored, was crucial for regioselectivity and versatility of the method.
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