First Example of C-3 Alkylation of Indoles with Activated Azetidines Catalyzed by Indium(III) Bromide

Indoles undergo smooth alkylation with N-tosylazetidines in the presence of indium(III) bromide in dichloroethane under mild conditions to produce the corresponding C-3 Substituted indole derivatives in good to high yields and with high selectivity. This is the first report oil the alkylation of indoles with activated azetidines.