Journal
SYNLETT
Volume -, Issue 8, Pages 1299-1302Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0029-1216724
Keywords
aldol reactions; asymmetric catalysis; metallocenes; phosphorus; copper
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We have prepared several ClickFerrophos families and tested for the Cu(I)-catalyzed asymmetric reductive aldol reaction of ketones and aldehydes with an acrylic ester in the presence of phenylsilane. The Cu(I)-ClickFerrophos complex is efficient for the reaction of ketones with methyl acrylate to afford the erythro adducts both highly diastereo- and enantioselectively; the diastereomeric ratio of erythro/threo is improved when compared to the analogous Taniaphos.
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